Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press36310.36691/RJA363ArticlesСтатьиReview ArticleInfluence of obesity on the natural course of asthma. There are more questions than answersВлияние ожирения на течение бронхиальной астмы. Вопросов больше, чем ответовGlushkovaE FГлушковаЕ Фglushkovaef@gmail.comShartanovaN VШартановаН ВInstitute of ImmunologyФМБА «ГНЦ Институт иммунологии» ФМБА России15122015126NO6 (2015)№6 (2015)51210032020Copyright ©; 2015, Pharmarus Print MediaCopyright ©; 2015, Фармарус Принт Медиа2015Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/363

Recent data about the influence of obesity on bronchial asthma natural course are represented in this article. There are different controversial data about interaction between these two multifactorial diseases. This problem is interested in many researchers working in the fields of endocrinology, therapy, pulmonology, allerglogy, genetics. Nevertheless this interest doesn’t give any clues to many questions coming from scientists.

В обзоре представлены данные о влиянии ожирения на течение бронхиальной астмы, известные в мире на данном этапе развития науки и медицины. Существуют противоречивые данные о взаимодействии этих двух многофакторных заболеваний. Проблема заинтересовала многих исследователей, работающих в областях эндокринологии, терапии, пульмонологии, аллергологии, генетики. Однако такая заинтересованность не дает разгадок на многие вопросы, возникающие у ученых.

asthmaobesityбронхиальная астмаожирениеGarshon A., Wang C., Guan J. et al. Burden of comorbidity in individuals with asthma. Thorax. 2010, v. 65, p. 612-618.Mannino D.M. Surveillance for asthma - United States, 1988-1999. MMWR Morb. Mortal. Wkly Rep. 2002, v 51, p. 1-13.Официальный сайт ВОЗ. Информационный бюллетень №307. Май 2011 г. http://www.who.int/mediacentre/fact-sheets/fs307/ru/.Lenzer J. Obesity related illness consumes a sixth of US healthcare budget. BMJ. 2010, v. 341, p. 6014.Lavie P. Who was the first to use the term Pickwickian in connection with sleepy patients? History of sleep apnoea syndrome. Sleep Med. Rev. 2008, v. 12, p. 5-17.Чарльз Диккенс «Жизнь Дэвида Копперфильда, рассказанная им самим», т. 1, гл. 9.Osler W. Principles and Practice of Medicine. 6th ed. London: Sidney Appleton. 1905.Burwell C.S., Robin E.D., Whaley R.D., Bicklemann A.G. Extreme obesity associated with alveolar hypoventilation; a Pickwickian syndrome (англ.). Am. J. Med. 1956, v. 5, p. 811-818.Lawson J.A., Rennie D.C., Dosman J.A. et al. Obesity, diet, and activity in relation to asthma and wheeze among rural dwelling children and adolescents. Journal of Obesity. 2013, article ID 315096, р. 9.Официальный сайт ВОЗ. Информационный бюллетень №311. Январь 2015 г. http://www.who.int/mediacentre/ factsheets/fs311/ru/.Stevens G.A., Finucane M.M., Paciorek C.J. et al. Nutrition Impact Model Study Group (Child Growth). Trends in mild, moderate, and severe stunting and underweight, and progress towards MDG 1 in 141 developing countries: a systematic analysis of population representative data. Lancet. 2012, v. 380, p. 824-834.Finucane M.M., Stevens G.A., Cowan M.J. et al. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9х1 million participants. Lancet. 2011, v. 377, p. 557-567.Food and agriculture organization of the united nations. Rome, 2013. Доклад ООН. 2013.Российский мониторинг экономического положения и здоровья населения. 2012, № 529, 30 с.Чучалин А.Г. Пульмонология. М., 2007, 227 с.Национальная программа «Бронхиальная астма у детей. Стратегия лечения и профилактика» Под ред. А.Г. Чучалина. 4-е издание. М. 2013, 182 с.Taylor B., Mannino D., Brown C. et al. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008, v. 63, p. 14-20.Sood A. Lean mass predicts asthma better than fat mass among females. European Respiratory Journal. 2011, v. 1, p. 65-71.American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am. J. Respir. Crit. Care Med. 2007, v. 175, p. 235-242.Dixon A.E., Shade D.M., Cohen R.I. et al. Effect of obesity on clinical presentation and response to treatment in asthma. J. Asthma. 2006, v. 43, p. 553-558.Tantisira K.G., Weiss S.T. Complex interaction in complex traits: obesity and asthma. Thorax. 2001, v 56, p. 64-74.Dixon A. et al. An Official American Thoracic Society Workshop Report: Obesity and Asthma. The Proceedings of the American Thoracic Society. 2010, v. 7, p. 325-335.Kier C. et al. Childhood Overweight and Obesity and Their Association With Asthma. Journal of Asthma & Allergy Educators. 2010, p. 27.Yh K. et al. Impact of Obesity on the Severity and Therapeutic Responsiveness ofAcute Episodes ofAsthma. J. Asthma. 2011, p. 23.Стандарты (протоколы) диагностики и лечения больных с неспецифическими заболеваниями легких (взрослое население). Приказ Минздрава Российской Федерации № 300 от 09.10.1998. M., 1998, с. 38Peters-Golden M., Swern A. et al. Influence of the body mass index on the response to controller agents. Eur. Respir. J. 2006, v. 27, p. 495-503.Berkenbosch J. The Effect of Obesity on ICU Course in Pediatric Patients With Status Asthmaticus. Chest. 2010, v. 138, p. 315.Чучалин А.Г Бронхиальная астма. М., «Русский врач». 2001, 280 с.Цибулькина В.Н., Цибулькин Н.А. Акушерство и гинекология. Лекции для врачей общей практики. Практическая медицина. 2011, № 6, с. 36-41.Wellen K., Hotamisligil G. Inflammation, stress and diabetes. J. Clin. Invest. 2005, v. 115, p. 1111-1119.Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose tissue expression of tumor necrosis factor- : direct role in obesity-linked insulin resistance. Science. 1993, v. 259, p. 87-90.Wellen K.E., Hotamisligil G.S. J. Clin. Invest. 2003, v. 112, v. 1785-1788.Murphy A., Tantisira K.G., Soto-Quiros M.E. et al. PRKCA: a positional candidate gene for bode mass index and astma. Am. J. Human. Genet. 2009, v. 85, p. 87-96.Trembly K., Lemire M., Provosr V. et al. Association study between the CX3CR1 gene and astma. Genes Immun. 2006, v. 7, p. 632-639.Sirois-Gagnon D., Chamberland A., Perron S., Brisson D., Gaudet D., Laprise C. Association of common polymorphisms in the fractalkine receptor (CX3CR1) with obesity. Obesity. 2011, v. 19, p. 222-227.De Luca C., Olefsky J.M. Inflammation and insulin resistance. FEBS Lett. 2008, v. 582, p. 97-105.Hotamisligil G.S. Inflammation and Metabolic Disorders. Nature. 2006, v. 444, p. 860-867.Nguyen M., Satoh H., Favelyukis S. et al. JNK and tumor necrosis factor a mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. Journal of Biological Chemistry. 2005, v. 280, p. 35361-35371.Uysal K.T., Wiesbrock S.M., Marino M.W., Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNFa function. Nature. 1997, v. 389, p. 610-614.Florez H., Castillo-Florez S., Mendez A. et al. C-reactive protein is elevated in obese patients with the metabolic syn drome. Diabetes Research and Clinical Practice. 2006, v. 71, p. 92-100.Heijink I.H. et al. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T-cells. Immunology. 2002, v. 107, p. 316-324.Simpson J.L., Scott R.J., Boyle M.J. et al. Differential Proteolytic Enzyme Activity in Eosinophilic and Neutrophilic Asthma. Am. J. Respir. Crit. Care Med. 2005, v. 172, p. 559-565.Scott H. Airway Inflammation is Augmented by Obesity and Fatty Acids in Asthma. European Respiratory Journal. 2011, v. 37, 478 p.Pretolani M., Goldman M. Cytokines involved in the down-regulation of allergic airway inflammation. Res. Immunol. 1997, v. 148, p. 33-38.Chin-Chance C., Polonsky K., Schoeller D. Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake. J. Clin. Endocrinol. Metab. 2000, v. 85, p. 2685-2691.Hall I.P. Genetics and pulmonary medicine 8: asthma. Thorax. 1999, v. 54, p. 65-69.Фрейдин М.Б., Огородова Л.М., Цой А.Н., Бердникова Н.Г Генетика бронхиальной астмы. В кн.: Генетика бронхолегочных заболеваний: Монография. Под ред. В.П. Пузырева, Л.В. Огородовой. (Серия монографий Российского респираторного общества). М., Издательский холдинг «Атмосфера». 2010, 160 с.Курбачева О.М., Павлова К.С. Фенотипы и эндотипы бронхиальной астмы: от патогенеза и клинической картины к выбору терапии. Росс. Аллергол. Журн. 2013, № 1, с. 15-24.Астафьева Н.Г, Гамова И.В., Удовиченко Е.Н., Перфилова И.А. Ожирение и бронхиальная астма. Леч. врач. 2014, № 5, с. 14.Shore S. Obesity and asthma: lessons from animal models. J. Appl. Physiol. 2007, v. 102, p. 516-528.