Infectious and noninfectious sensibilization of patients with bronchial asthma and chronic obstructive pulmonary disease



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Abstract

The study included 169 patients, particulary 33 healthy people, 69 patients with asthma, 24 patients with asthma combined with chronic obstructive pulmonary disease, 35 patients with chronic obstructive pulmonary disease and 8 patients with community-acquired pneumonia. IgE was determined to mite allergens, house dust, combined pollen meadow grasses, trees and weeds. IgE and IgG were determined to allergens of Strept. pneumonia, Haemofil. influenzae, Neisseria perflava, Staph. aureus. Presence, multiplicity, severity and combination of sensibilization were detected by the presence of specific IgE to infectious and atopic allergens. We revealed sensibilization of all studied groups, including healthy people and patients with chronic obstructive pulmonary disease and community-acquired pneumonia without clinical signs of allergies. There is a statistically significant direct correlation between IgE and IgG reaction to Strept. рneumonia and Haemofil. influenzae of healthy people and patients. There is no correlation between the IgE and IgG reaction of healthy people and patients to Neisseria perflava and Staph. aureus.

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About the authors

G B Fedoseev

First Saint-Petersburg State I.P. Pavlov Medical University

Email: fedoseevsp@mail.ru
Russia

V I Trofimov

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

V G Timchik

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

K V Negrutsa

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

V I Golubeva

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

E V Gorovneva

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

T S Razumovskaya

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

I V Birula

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

V A Alexandrin

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

K N Kryakunov

First Saint-Petersburg State I.P. Pavlov Medical University

Russia

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