Vol 6, No 3 (2009)

Pruritus is a constant and principal symptom of atopic dermatitis (AD), because of it's impact on quality of life. There fore studying of itch mechanisms is actual and could substantiate the ways of AD management. The present review is devoted to consideration of the modern data on this problem.

This is the 2 part of review, devoted to the role of food additives in food allergy and other kind of reactions to food.

Background. The detection of prevalence of allergic rhinitis among children living in big industrial cities and rural areas of the Rostov region. Methods. In accordance with ISAAC program the two-stage epidemiological research included screening questionnaire of 7254 pupils, on the second stage a functional and allergy examination of the group on the examination of 963 pupils, who gave positive answer to any of the questions in the questionnaire, has been carried out. Results. In Rostov-on-Don and in the towns of the Rostov region pupils of primary school age suffer from allergic rhinitis significantly more often than those in the rural districts (p<10-6 and p=0,0002). The number of pupils in the junior group on the examination who demonstrated allergic rhinitis is higher in Rostov-on-Don, while the number of children in the senior examined group who demonstrated allergic rhinitis is higher in the rural districts of the Rostov region. The children in the junior group demonstrated apparent increase in allergic sensitization for domestic, epidermal and food allergens, while the children in the senior group demonstrated apparent increase of allergic sensitization for pollen and domestic allergens. The IgE level was increased with the patient's age and with the severity of allergic rhinitis. Conclusions. The comparison of the results of allergic rhinitis prevalence research in children using ISAAC technique and the data of official statistics has revealed insufficient level of discover assessment of allergic rhinitis in the Rostov region.

Цель. Ретроспективный анализ эффективности и безопасности применения мометазона фуроата в наружной терапии АтД у подростков. Материалы и методы. В исследование было включено 22 пациента с АтД различной степени тяжести в возрасте от 13 до 18 лет (средний возраст 16,0±2,1), наблюдавшихся в отделении аллергии и иммунопатологии кожи ГНЦ Института иммунологии в период с 2006 по 2008 гг. Каждый из пациентов получал мометазона фуроат (Элоком) в виде крема, мази или лосьона на пораженные участки кожи в течение различного периода времени. Результаты. При использовании мометазона фуроата наблюдалось быстрое уменьшение симптомов АтД, в единичных случаях нерационального использования препарата отмечено развитие минимальных местных побочных эффектов (розацеа, фолликулит). Признаков подавления функции гипоталамо-гипо физарно-надпочечниковой системы ни в одном случае выявлено не было. Заключение. Мометазона фуроат (Элоком) является высокоэффективным и безопасным средством для лечения АтД у больных подросткового возраста.