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Vol 10, No 1 (2013)

Articles
IMMUNOGENETICS AND BIOMEDICINE
Khaitov R.M., Alexeev L.P.
Abstract
Review is devoted to recent achievements in human immunogenetics, physiology of HLA, genetic basis of predisposition to diseases and susceptibility to adverse environment factors implication of immunogenetics in practical medicine.
Russian Journal of Allergy. 2013;10(1):5-14
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PHENOTYPES AND ENDOTYPES OF BRONCHIAL ASTHMA: FROM PATHOGENESIS AND CLINICAL FEATURES TO THERAPY
Kurbacheva O.M., Pavlova K.S.
Abstract
Questions of bronchial asthma heterogeneity, approaches to allocation of various phenotypes on the basis of clinical signs, biological and genetic markers and endotypes taking into account an etiology and pathophysiology of the disease are considered in the article. Allocation of phenotypes / endotypes promote the best understanding of essence of a disease and it is expedient for development of an individual approach to therapy as some options of a current OH can differ the resistant answer to standard treatment.
Russian Journal of Allergy. 2013;10(1):15-24
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ALLERGY TO STINGING INSECTS: GLOBAL SITUATION
Govorushko S.M.
Abstract
The most significant allergenic stinging insects (wasps, bees, hornets, bumblebees) are considered. Information on the percentage of people having allergic reactions to stings total population in different countries is provided. The relation between the frequency of allergic reactions to certain professions is shown. Regional differences in mortality from allergies to the venom of bees and wasps are discussed. Mortality figures from allergies to venom of stinging insects in different countries are given. Global mortality from stinging insect allergy is estimated.
Russian Journal of Allergy. 2013;10(1):25-32
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CURRENT TRENDS IN THE PHARMACOTHERAPY OF ATOPIC ASTHMA
Astafieva N.G., Gamova I.V., Udovitchenko E.N., Perfilova I.A., Kobzev D.Y., Kenesarieva J.M.
Abstract
Asthma is a common chronic respiratory disease, characterized by different mechanisms and the development of heterogeneous phenotypes. This review discusses the main pharmacotherapy innovations and their possible clinical application.
Russian Journal of Allergy. 2013;10(1):33-41
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PRODUCTION OF BETULA PENDULA POLLEN Bet v 2 ALLERGEN WITH IMMUNOREGULATORY SIGNALS AND ITS RECOGNITION BY IgE ANTIBODIES
Ryabova N.L., Kuzmenko Y.V., Tyutyaeva V.V., Andreev I.V., Sankov M.N., Starodubova E.S., Preobrazhenskaya O.V., Martynov A.I., Karpov V.L.
Abstract
Background. Creation of recombinant proteins, containing profilin and signal peptides which provide proteasomal and lysosomal degradation pathways of proteins. Materials and methods. Plasmid pET-Bet v 2, encoding Bet v 2 allergen, was used as a base vector. Two signal peptides: C-terminal fragment of ornithine decarboxylase (ODCsig) and N-terminal fragment of human invariant chain (Ii) — were cloned into this vector. Recombinant proteins were produced in BL21 (DE3) strain of E. coli. The recombinant protein was purified using NiNTA agarose. Immunological specificity of the recombinant proteins was estimated by means of immune-enzyme methods using sera of patients suffering from birch pollen allergy. Results. Bet v 2 allergen (profilin) of Betula pendula pollen was modified by immunoregulatory peptides in order to change the IgE/IgG response ratio. Ornithine decarboxylase proteasome degradation signal was used to enhance the Th1 response and human invariant chain signal directed to lysosomes was used in order to enhance Th2 response. The production system of recombinant allergen Bet v 2 preparation suitable for immunological tests was developed. The produced highly purified chimeric proteins preparations bound IgE antibodies of allergic to birch pollen patients' sera efficiently. Conclusion. The new chimeric allergens based on Bet v 2 protein of Betula pendula pollen were created and isolated.
Russian Journal of Allergy. 2013;10(1):42-46
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EFFICIENCY OF ALLERGENSPECIFIC IMMUNOTHERAPY IN ADOLESCENTS WITH POLLINOSIS
Balabolkin I.I., Beljaeva E.V., Sosnina O.B., Ksenzova L.D., Larkova I.A.
Abstract
Introduction. Efficiency of ASIT in adolescents with pollinosis is not enough investigated. Materials and methods. Authors investigated 45 adolescents with pollinosis of 10—17 years old. Investigation included skin tests with atopic allergens, determine of total IgE, (ELISE, Russia), specific IgE (MAST, USA), sIL2R, IL4, IL5, IL8, IL10, IL13, IFNγ (ELISE, Belgium) in blood serum. Rush subcutaneous ASIT with pollen allergens was performed. Results. ASIT proved to be effective in 39 (86,4%) adolescents with pollinosis. In 52% adolescents with pollinosis and food allergy to products of plant origin was noticed increasing of tolerance to them. Normalization of levels of IL5 and IL 10 in blood serum was noticed. ASIT was more efficient in children with moderate increasing of IgE levels in blood serum. Conclusion. ASIT is effective method of treatment of adolescents with pollinosis.
Russian Journal of Allergy. 2013;10(1):47-51
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THE FUNCTIONAL STATUS OF THE SKIN BARRIER IN CHILDREN WITH ATOPIC DERMATITIS
Kindeeva E.T., Varlamov E.E., Pampura A.N.
Abstract
Introduction. One of the factors in the pathogenesis of atopic dermatitis is a dysfunction of the skin barrier. Background. To reveal the features of the barrier function of the skin in children with atopic dermatitis by measuring transepidermal water loss (TEWL) and the pH of the skin. Methods. The study included 98 children with atopic dermatitis. All patients measurement was performed by TEWL (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (Skin-pHMeter, Multi Probe Adapter MPA 5/9, Courage + Khazaka). Results. TEWL value was significantly higher in children with severe atopic dermatitis (p=0,00001), in children up to 3 years (p=0,002), in patients with skin colonization of Staphylococcus aureus (p=0,006) and with specific IgE to staphylococcal enterotoxins. Skin pH was significantly higher in children with severe atopic dermatitis (p=0,0001), and in children under the age of 3 years (p=0,04). Conclusion. The determination of the level of TEWL and skin pH to assess the degree of inflammation activity in atopic dermatitis and to justify use of topical therapy, aimed to restoring the epidermal barrier of the skin at children with atopic dermatitis, is substantiated.
Russian Journal of Allergy. 2013;10(1):52-57
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PRIMARY IMMUNODEFICIENCIES - NOT A RARE DISEASE, BUT A DIFFICULT DIAGNOSIS. COMMON VARIABLE IMMUNODEFICIENCY (ANALYSIS OF CLINICAL CASES)
Latysheva E.A.
Abstract
Primary immunodeficiencies (PID) occur more often than we used to think. Due to the low awareness of physicians about this disease, from the onset of symptoms to diagnosis patients are difficult path, often measured in years. In PID adults the most common is humoral immunity disorder. Given the wide range of clinical phenotypes of the disease, immunologist may be far from the GP during diagnosis. The article presents a case of a patient with common variable immune deficiency, that was masked under the brain tumor.
Russian Journal of Allergy. 2013;10(1):58-61
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THERAPEUTIC EFFICACY OF A POLY-FUNCTIONAL ANTIALLERGIC DRUG - RUPATADINE
Gushchin I.S.
Abstract
Rupatadine is a new poly-functional agent (selective histamine H 1-receptor and PAF-receptor antagonist with additional anti-inflammatory potency) for the management of patients with allergic rhinitis and chronic urticaria. It has a rapid onset of action, and its long-lasting effect permits once-daily dosing. It has been shown that rupatadine is effective, well-tolerated and safe in relieving symptoms in patients with seasonal and perennial/ intermittent and persistent allergic rhinitis and chronic urticaria.
Russian Journal of Allergy. 2013;10(1):63-77
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PECULARITIES OF INNATE IMMUNITY IN CHILDREN WITH RECCURENT WHEEZING
Zaytseva O.V., Lokshina E.E., Gromadina O.V., Dmitrieva E.V., Malinovskaya V.V., Shklyaeva I.V., Guseva T.S., Parshina O.V., Parfenov V.V.
Abstract
Background. To study clinical importance of indicators of innate immunity in children with recurrent wheezing and the effectiveness of recombinant interferon α-2b (Viferon, Russia) in complex treatment. Methods. 187 children with recurrent wheezing and 16 healthy children were included in this study aged from 1 to 10 years. It was investigated the level of eosinophilia, total IgE, level of subpopulations of blood lymphocytes, immunoregulatory index, the expression levels of TLR2 and TLR4 on the surface of monocytes, the percentage of proinflammatory monocytes, and effectiveness of therapy was evaluated as well. Results. We revealed increase of natural killers, proinflammatory monocytes, eosinophils, with increased expression of TLR2, which is in inverse proportion to the frequency of the ARI in children with recurrent wheezing. After treatment of Viferon we revealed reduction ARls, decrease of episodes and duration of wheezing in children. Conclusion. Revealed changes of innate immunity and the reduction of activity indicators of adaptive management showed signs of deficiency of the immune system in the group of children with recurrent wheezing. Using of interferon α-2b in the complex therapy of children with recurrent wheezing has a positive therapeutic and protective effect.
Russian Journal of Allergy. 2013;10(1):78-84
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PREVALENCE OF ALLERGIC DISEASES AMONG YOUNG PEOPLE
Kozulina I.E., Pavlova K.S., Kurbacheva O.M.
Russian Journal of Allergy. 2013;10(1):85-86
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MODERN VIEW ON THE HYPERSENSITIVITY REACTIONS FOLLOWING X-RAY CONTRAST ADMINISTRATION
Lebedeva N.V., Miasnikova T.N., Latysheva T.V.
Russian Journal of Allergy. 2013;10(1):87-90
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IMMUNE RESPONSE DEVIATION DURING ALLERGEN-SPECIFIC IMMUNOTHERAPY
Pichuzhkina O.V., Kurbacheva O.M.
Russian Journal of Allergy. 2013;10(1):91-92
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CLINICAL, ALLERGOLOGICAL AND IMMUNOLOGICAL DATA IN PATIENTS WITH COMPLICATED BRONCHIAL ASTHMA
Isakova I.I., Gumeniuk S.A., Polner S.A., Barkhina T.G., Gushchin M.Y.
Russian Journal of Allergy. 2013;10(1):93-96
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A CATAMNESTIC ANALYSIS OF THE OBSTETRICAL HISTORY OF PATIENTS WITH PRIMARY IMMUNODEFICIENCY
Yurenkova A.A., Latysheva E.A., Latysheva T.V., Suhih G.T.
Russian Journal of Allergy. 2013;10(1):97-101
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