Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media63410.36691/RJA634Research ArticlePRIMARY IMMUNODEFICIENCIES - NOT A RARE DISEASE, BUT A DIFFICULT DIAGNOSIS. COMMON VARIABLE IMMUNODEFICIENCY (ANALYSIS OF CLINICAL CASES)LatyshevaE Aealat@mail.ruInstitute of Immunology15022013101586110032020Copyright © 2013, Pharmarus Print Media2013Primary immunodeficiencies (PID) occur more often than we used to think. Due to the low awareness of physicians about this disease, from the onset of symptoms to diagnosis patients are difficult path, often measured in years. In PID adults the most common is humoral immunity disorder. Given the wide range of clinical phenotypes of the disease, immunologist may be far from the GP during diagnosis. The article presents a case of a patient with common variable immune deficiency, that was masked under the brain tumor.primary immunodeficiencycommon variable immune deficiencybrain tumorimmunoglobulinsпервичный иммунодефицитобщая вариабельная иммунная недостаточностьопухоль головного мозгаиммуноглобулины[Marodi L., Notarangelo L.D. Immunological and genetic bases of new primary immunodeficiencies.NAT REV IMMUNOL. 2007, v. 7, p. 851-861.][U.S. Department of Health and Human Services. National Institutes of Health. PAR-08-206: Investigations on Primary Immunodeficiency Diseases, 2009.][Bousfiha A.A., Jeddane L., Ailal F., Benhsaien I., Mahlaoui N., Casanova J.L., Abel L. Primary Immunodeficiency Diseases Worldwide: More Common than Generally Thought. J. Clin. Immunol. 2012, v. 31 (http://www.ncbi.nlm.nih.gov/pubmed?term=3.%09Bousfiha%20AA%2C%20Jeddane%20 L%2C%20Ailal%20F%2C%20Benhsaien%20I%2C%20 Mahlaoui%20N%2C%20Casanova%20JL%2C%20Abel%20L.%20Primary%20Immunodeficiency%20Diseases%20 Worldwide%3A%20More%20Common%20than%20Ge-nerall).][Francisco A. Bonilla, Leonard Bernstein, David A. Khan, Zuhair K. Ballas et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Annals of Allergy, Asthma and Immunology. 2005, v. 94, p. 1-60.][Ведение больных с первичным иммунодефицитом в акушерстве. Методические рекомендации для врачей под редакцией академика РАН и РАМН Р.М. Хаитова, академика РАМН Г.Т. Сухих. «Фармарус Принт Медиа», М., 2012, 5 с.][Aghamohammadi А., Abolhassani Н., Moazzami К., Parvaneh N., Rezaei N. Correlation Between Common Variable Immunodeficiency Clinical Phenotypes and Parental Consanguinity in Children and Adults. J. Investig Allergol Clin. Immunol. 2010, v. 20, p. 372-379.][Simon H.U., Späth P.J. IVIG-mechanisms of action. Allergy. 2003, v. 58, p. 543-552.][Pourpak Z., Aghamohammadi A., Sedighipour L., Farhoudi A., Movahedi M., Gharagozlou M. et al. Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency. J. Microbiol. Immunol. Infect. 2006, v. 39, p. 114-120.][Vorechovsky I., Scott D., Haeney M.R., Webster D.A. Chromosomal radiosensitivity in common variable immune deficiency. Mutat. Res. 1993, v. 290, p. 255-264.]