Russian Journal of Allergy

Российский Аллергологический Журнал

1810-88302686-682X

Publishing House ABV Press

628

10.36691/RJA628

Articles

Статьи

Research Article

THE FUNCTIONAL STATUS OF THE SKIN BARRIER IN CHILDREN WITH ATOPIC DERMATITIS

ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ КОЖНОГО БАРЬЕРА У ДЕТЕЙ С АТОПИЧЕСКИМ ДЕРМАТИТОМ

Kindeeva

E T

Киндеева

Е Т

aekindeeva@bk.ru

Varlamov

E E

Варламов

Е Е

Pampura

A N

Пампура

А Н

Moscow Research Institute of Pediatric and Child SurgeryФГБУ «Московский научно-исследовательский институт педиатрии и детской хирургии» Минздрава России

15022013

101

NO1 (2013)

№1 (2013)

525710032020

2013

Pharmarus Print Media

Фармарус Принт Медиа

https://rusalljournal.ru/raj/article/view/628

Introduction. One of the factors in the pathogenesis of atopic dermatitis is a dysfunction of the skin barrier. Background. To reveal the features of the barrier function of the skin in children with atopic dermatitis by measuring transepidermal water loss (TEWL) and the pH of the skin. Methods. The study included 98 children with atopic dermatitis. All patients measurement was performed by TEWL (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (Skin-pHMeter, Multi Probe Adapter MPA 5/9, Courage + Khazaka). Results. TEWL value was significantly higher in children with severe atopic dermatitis (p=0,00001), in children up to 3 years (p=0,002), in patients with skin colonization of Staphylococcus aureus (p=0,006) and with specific IgE to staphylococcal enterotoxins. Skin pH was significantly higher in children with severe atopic dermatitis (p=0,0001), and in children under the age of 3 years (p=0,04). Conclusion. The determination of the level of TEWL and skin pH to assess the degree of inflammation activity in atopic dermatitis and to justify use of topical therapy, aimed to restoring the epidermal barrier of the skin at children with atopic dermatitis, is substantiated.

Введение. Одним из факторов патогенеза атопического дерматита (АтД) является нарушение функции кожного барьера. Цель исследования. Выявить особенности барьерной функции кожи у детей с АтД путем оценки трансэпидермальной потери жидкости (ТЭПВ) и pH поверхности кожи. Материалы и методы. В исследование включены 98 детей с АтД. Всем пациентам выполнено измерение в очаге воспаления ТЭПВ (Tewameter TМ 300, Multi Probe Adapter MPA 5/9, Courage+Khazaka) и pH поверхности кожи (Skin-pH-Meter, Multi Probe Adapter MPA 5/9, Courage+Khazaka). Результаты. Значение тЭПВ было достоверно выше у детей с тяжелым АтД (р=0,00001), у детей в возрасте до 3 лет (р=0,002), у пациентов с наличием колонизации кожи Staphylococcus aureus (р=0,006) и наличием аллерген-специфических IgE к стафилококковым энтеротоксинам. pH кожи было достоверно выше у детей с тяжелым АтД (р=0,00001) и у детей в возрасте до 3 лет (р=0,04). Заключение. Определение уровня ТЭПВ и pH поверхности кожи позволяет объективно оценить степень активности воспалительного процесса при АтД и оправдывает активное использование у детей с АтД местной терапии, направленной на восстановление эпидермального барьера кожи.

atopic dermatitisskin barriertansepidermal water lossskin pH

атопический дерматиткожный барьертрансэпидермальная потеря водыpH кожи

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