The relationship between sensitization to allergens of cow’s and goat’s milk at children with atopic dermatitis

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Abstract


Introduction. The main principle of treatment of cow’s milk allergy (CMA) is the elimination from the diet of cow’s milk. However recently has been discussing the possibility to substitute the cow’s milk with goat’s milk in children with allergy to cow s milk protein. Background. To determine the relationship between sensitization to cow’s milk specific allergens in goat’s milk sensitized children. Methods. The study included 88 children with suspected allergy to CMA. All patients underwent determination of specific IgE to allergen of cow’s and goat’s milk allergen (ImmunoCAP 100 Phadia AB). We identified 35 children with sensitization to cow’s milk and measured specific IgE to α-laktalbumin, β-lactoglobulin and casein. Results. Sensitization to goat’s milk was estimated in 83% of patients with sensitization to cow’s milk. There was a significant positive correlation between the concentration of specific IgE to goat’s milk allergen and specific IgE to the cow’s milk allergen (R=0,91, p=0,0000001), a-laktalbumin (R=0,76, p=0,000007), β-lactoglobulin (R=0,72, p=0,000038) and casein (R=0,91, p=0,0000001). Conclusion. Formulas based on goat milk can not be considered hypoallergenic for children allergic to cow’s milk. Crosssensitization is mediated mainly with sensitization to casein. Introduction of goat milk and its derivatives in the diet of a child with an allergy to cow’s milk can be proven only by the absence of clinically relevant sensitization to goat milk.

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E E Varlamov

Moscow Research Institute of Pediatric and Child Surgery

T S Okuneva

Moscow Research Institute of Pediatric and Child Surgery

A N Pampura

Moscow Research Institute of Pediatric and Child Surgery

Email: apampura@pedklin.ru

  1. Staiano A. Diagnosis and therapy of allergy to cow’s milk proteins in the breast-fed baby: new guidelines. Minerva Pediatr. 2007, v. 59, p. 447-448.
  2. Meyer R. New guidelines for managing cow’s milk allergy in infants. J. Fam. Health Care. 2008, v. 18, p. 27-30.
  3. Marina O., Fernandez A., Follett F.R. et al. Cow’s milk protein allergy: proposed guidelines for the management of children with cow’s milk protein allergy. Arch. Argent. Pediatr. 2009, v. 107, p. 459-467.
  4. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. Pediatr. Allergy Immunol. 2010, v. 21, p. 1-125.
  5. Scientific opinition on the suitability of goat milk protein as a source of protein in infant formulae and in follow-on formula. EFSA Journal. 2012, v 10, p. 2603.
  6. Orlando J.P., Breton-Bouveron A. Anaphylactoid reaction to goat’s milk. Allerg. Imminol. (Paris). 2000, v. 32, p. 231-232.
  7. Ah-Leung S., Bernard H., Bidat E. et al. Allergy to goat and sheep milk without allergy to cow’s milk. Allergy. 2006, v. 61, p. 1358-1365.
  8. Tavares B., Pereira C., Rodrigues F. et al. Goat’s milk allergy. Allergol. Immunopathol. (Madr.). 2007, v. 35, p. 113-116.
  9. Clark S., Sherbon J.W. α-s1 casein, milk composition and coagulation properties of goat milk. Small Ruminant Research. 2000, v. 38, p. 123-134.
  10. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М., «МедиаСфераб». 2002, с. 312.
  11. Celic-Bilgili S., Mehl A., Verstege A. et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin. Exp. Allergy. 2005, v. 35, p. 268-273.
  12. Sampson H.A. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J. Allergy Clin. Immunol. 2001, v. 107, p. 891-896.
  13. Vita D., Passalacqua G., Di Pasquale G. et al. Ass_s milk in children with atopic dermatitis and cow’s milk allergy: crossover comparison with goat’s milk. Pediatr. Allergy Immunol. 2007, v. 18, p. 594-598.
  14. Bellioni-Businco B., Paganelli R., Lucenti P. et al. Allergenicity of goat’s milk in children with cow’s milk allergy. J. Allergy Clin. Immunol. 1999, v. 103, p. 1191-1194.
  15. Spuergin P., Walter M., Schiltz E. et al. Allergenicity of alpha-caseins from cow, sheep, and goat. Allergy. 1997, v. 52, p. 293-298.
  16. Prosser C. et al. Digestion of milk proteins from cow or goat milk infant formula. Poster paper presented at the 11th Asian Congress of Paediatrics, Bangkok, Thailand, 2003, 2-7 November 2003.
  17. Bernard H., Creminon C., Yvon M., Wal J.M. Specificity of the human IgE response to the different purified caseins in allergy to cow’s milk proteins. Int. Arch. Allergy Immunol. 1998, v. 115, p. 235-244.

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