Immunological and allergological aspects of macrolides application in clinic



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The review analyzes clinical significance of immunotropic properties of macrolides. Macrolides have effect of phagocytic activity and cell motility, inhibit production of proinflammatory cytokines, increase antimicrobial function of mucosa epithelium. They significantly decrease the intensity of inflammatory reactions in local and systemic infectious processes, especially in respiratory tract pathology including that of allergic genesis. Efficacy of macrolides in bronchial asthma is extended by suppressing eosinophil functioning, antispastic effect of these preparations over smooth muscles and decreasing of mucus formation in bronchi.

References

  1. Страчунский Л.С., Козлов С.Н. Макролиды в современной клинической практике. Смоленск: Русич, 1998, 304 с.
  2. Labro М.Т. Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or «Immuno-Fairy Tales»? Clin Microbiol Rev., 2000, v. 13, p. 615- 650.
  3. Bosnar M., Kelneric Z., Munic V., Erakovic V., Parnham M.J. Cellular Uptake and Efflux оf Azithromycin, Erythromycin, Clarithromycin, Telithromycin, and Cethromycin. Antimicrob. Agents Chemother., 2005, v. 49, p. 2372-2377.
  4. Denis A., Agouridas C., Auger J. M. et al. Synthesis and antibacterial activity of HMR 3647, a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. Bioorg. Med. Chem. Lett., 1999, v. 9, p. 3075-3080.
  5. Ma Z., Clark R.F., Brazzale A. et al. Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. J. Med. Chem., 2001, v. 44, p. 4137-4156.
  6. Фещенко Ю. И. Макролиды. Доктор, 2000, № 3, с. 56-60.
  7. Craig W.A., Gudmundson S. Postantibiotic effect. In: Antibiotics in Laboratory Medicine. Loran V. (Ed.), Baltimore ect., 1996, p. 403-431.
  8. Самсыгина Г.А., Охлопкова К.А., Суслова О.В. Антибиотики и химиотерапия, 2000, № 11, с. 29-30.
  9. Garcia I., Pascual A., Guzman M.C., Perea E.J. [Effect of miocamycin and erythromycin on the activity of human neutrophils against Staphylococcus aureus]. Enferm. Infecc. Microbiol. Clin., 1991, v. 8, p. 459-463.
  10. De Vecchi E., Nicola L., Zucchetti E., Drago L. In vitro induction of resistance by tissue concentrations of azithromycin, clarithromycin, cefixime and amoxicillin/clavulanate in clinical isolates of Streptococcus pyogenes. J. Chemother., 2006, v. 18, p. 379-388.
  11. Weisblum B. Macrolide resistance. Drug Resist. Updat., 1998, v. 1, p. 29-41.
  12. Frank M.O., Sullivan G.W., Carper H.T., Mandell G.L. In vitro demonstration of transport and delivery of antibiotics by polymorphonuclear leukocytes. Antimicrob. Agents Chemother., 1992, v. 36, p. 2584-2588.
  13. Gladue R.P., Bright G.M., Isaacson R.E., Newborg M.F. In vitro and in vivo uptake of azithromycin (CP-62,993) by ph-agocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother., 1989, v. 33, p. 277-282.
  14. Яшина Л.А, Когосова Л.С., Игнатьева В.И. и соавт. Сравнительная клинико-иммунологическая эффективность азитромицина (сумамед) и эритромицина при лечении больных острой пневмонией с затяжным течением и хронического гнойно-обструктивного бронхита. Укр. пульмонол. журн., 1998, № 1, с. 34-36.
  15. Фомина И.П. Современные макролиды, особенности действия, значение в лечении бактериальных инфекций. Антибиотики и химиотерапия, 1995, № 4, с. 47-56.
  16. Labro M.T. Effects of macrolides on leukocytes and inflammation. In S.H. Zinner, L.S. Young, J.F. Acar and H.C. Neu (ed.). Expanding indications for the new macrolides, azalides, and streptogramins. Marcel Dekker, Inc., New York, N.Y., 1997, p. 101-116.
  17. Munic V., Bosnrar M., Kelneric Z. et al. Macrolide uptake and release by HL-60 and human polymorphonuclear (PMN) cells. In: Program and abstracts of 6th Int. Conf. Macrolides, Azalides, Streptogramins, Ketolides and Oxazolidinones., 2002, Abstr. 4.06, p. 120.
  18. Pascual A., Rodriguez-Bano J., Ballesta S. et al. Azithromycin uptake by tissue cultured epithelial cells. J. Antimicrob. Chemother., 1997, v. 39, p. 293-295.
  19. Vazifeh D., Abdelghaffar H., Labro M.T. Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin. Antimicrob. Agents Chemother., 1997, v. 41, p. 2099-2107.
  20. Miossec-Bartoli C., Pilatre L., Peyron P. et al. The new ketolide HMR3647 accumulates in the azurophil granules of human polymorphonucelar cells. Antimicrob. Agents Chemother., 1999, v. 43, p. 2457-2462.
  21. Vazifeh D., Preira A., Bryskier A., Labro M.T. Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils. Antimicrob. Agents Chemother., 1998, v. 42, p. 1944-1951.
  22. Labro M. T. , Abdelghaffar H., Babin-Chevaye C. Interaction of the new ketolide ABT-773 (cethromycin) with human polymorphonuclear neutrophils and the phagocytic cell line PLB-985 in vitro. Antimicrob. Agents Chemother., 2004, v. 48, p. 1096-1104.
  23. Culic O., Erakovic V., Parnham M.J. Anti-inflammatory effects of macrolide antibiotics. Eur. J. Pharmacol., 2001, v. 429, No. 1-3, p. 209-229.
  24. Labro M. T. Effects of macrolides on host natural defenses. In: Bryskier A.J., Butzler J.P., Neu H.C., Tulkens P.M., editors. Macrolides: chemistry, pharmacology, and clinical uses. Paris, France: Arnette-Blackwell, 1993, p. 389-408.
  25. Labro M T. Immunological effects of macrolides. Curr. Opin. Infect. Dis., 1998, v. 11, p. 681-688.
  26. Amsden G.W. Anti-inflammatory effects of macrolides - аn underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J. Antimicrob Chemother., 2005, v. 55, p. 10-21.
  27. Langelot M., Cellerin L., Germaud P. [Anti-inflammatory effects of macrolides: applications in lung disease]. Rev. Pneumol. Clin., 2006, v. 62, p. 215-222.
  28. Ouadrhiri Y., Scorneaux B., Sibille Y., Tulkens P.M. Mechanism of intracellular killing and modulation of abtibiotic susceptibility of Listeria monocytogenes in THP-1 macrophages activated by gamma interferon. Antimicrob. Agents Chemother., 1999, v. 43, p. 1242-1251.
  29. Fuji T., Kadota J.-I., Morikawa T. et al. Inhibitory effect of erythromycin on interlukin-8 production by alpha, 25-dihydroxy vitamin D3-stimulated THP-1 cells. Antimicrob. Agents Chemother., 1996, v. 40, p. 1548-1551.
  30. Kawasaki S., Takizawa H., Ohtoshi T. et al. Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro. Antimicrob. Agents Chemother., 1998, v. 42, p. 1499-1502.
  31. Khan A.A., Slifer T.R., Araujo F.G., Remington J.S. Effect of clarythromycin and azithromycin on production of cytokines by human monocytes. Int. J. Antimicrob. Agents., 1999, v. 11, p. 121-132.
  32. Morikawa K., Watabe H., Araake H., Morikawa S. Modulatory effects of antibiotics on cytokine production by humah monocytes in vitro. Antimicrob. Agents Chemother., 1996, v. 40, p. 1366-1370.
  33. Feldman C., Anderson R., Theron A.J. et al. Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. Inflamation, 1997, v. 21, p. 655-665.
  34. Khair O.A., Devalia J.L., Abdelaziz M.M. et al. Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and SiCAMI by cultured human bronchial epithelial cells. Eur. Respir. J., 1995, v. 8, p. 1451-1457.
  35. Schultz MJ. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J. Antimicrob. Chemother., 2004, v. 54, p. 21-28.
  36. Shinkai M, Rubin BK. Macrolides and airway inflammation in children. Paediatr. Respir. Rev., 2005, v.6, p. 227-235.
  37. Gorski N.P., Krzeski A. [Medical management of chronic rhinosinusitis with macrolides]. Pol. Merkur. Lekarski., 2005, v. 19, p. 490-493.
  38. Kohyama T., Takizawa H., Kawasaki S. et al. Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. Antimicrob. Agents Chemother., 1999, v. 43, p. 907-911.
  39. Morikawa K., Oseko F., Morikawa S., Iwamoto K. Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. Antimicrob. Agents Chemother., 1994, v. 11, p. 2643-2647.
  40. Parnham MJ. Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections. Curr. Opin. Infect. Dis., 2005, v. 18, p. 125-131.
  41. Karrow N.A., McCay J.A., Brown R.D. et al. Evaluation of the immunomodulatory effects of the macrolide antibiotic, clarithromycin, in female B6C3F1 mice: a 28-day oral gavage study. Drug. Chem. Toxicol., 2001, v. 24, p. 19-37.
  42. Dugnani S., Demartini G., Triscari F. , Fraschini F. Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. J. Chemother., 1993, v. 5, p. 228-232.
  43. Sacre Hazouri JA. [Macrolides. Antiinflammatory and immunomodulator effects. Indication in respiratory diseases]. Rev. Alerg. Mex., 2006, v. 53, p. 108-122.
  44. Синопальников А.И. Новые горизонты применения макролидов при инфекциях дыхательных путей. Новые Санкт-Петербургские врачебные ведомости, 2004, № 4, с. 60-65.
  45. Bacci P. , Grossi A., Vannucchi A.M. et al. Effects of miocamycin and erythromycin on polymorphonuclear cell function. J. Chemother., 1992, v. 5, p. 268-270.
  46. Kadota J.-I., Iwashita T. , Matsubara Y. et al. Inhibitory effect of erythromycin on superoxide anion production by human neutrophils primed with granulocyte-colony stimulating factor. Antimicrob. Agents Chemother., 1998, v. 42, p. 1866-1867.
  47. Sugiyama Y., Kitamura S., Kasahara T. Cytokines production from alveolar macrophages of rats fed by long term, low dose erythromycin. In: European Respiratory Society. Annual Congress, 1997, abstr. 0432.
  48. Hori S., Sato J., Kawamura M. Macrolides increase endogenous glucocorticoid levels. In: The 36th Conference on Antimicrobial Agents and Chemotherapy. New Orleans, 1996, abstr. A83.
  49. Шмелев Е.И., Ергешев А.Е., Шмелева Н.М., Сидорова В.П. Кларитромицин в лечении обострений хронической обструктивной болезни легких. Пробл. туб. и болезней легких, 2006, № 8, c. 42-47.
  50. Lim J.H., Park B.K., Yun H.I. Pharmacokinetic/pharmacodynamic modelling of roxithromycin for the inhibitory effect of tumour necrosis factor-alpha and interleukin-6 production in dogs. J. Vet. Med. A Physiol. Pathol. Clin. Med., 2006, v. 53, p. 394-398.
  51. Johnston S.L. Macrolide antibiotics and asthma treatment. J. Allergy Clin. Immunol., 2006, v. 117, p. 1233-1236.
  52. Parnham M.J. Antibiotics, Inflammation and its resolution: an overview. In Rubin B.K., Tamaoki J. Eds. Antibiotics as anti-inflammatory and immunomodulatory agents, Basel: Birk Verlag, 2004, p. 27-48.
  53. Culic O., Erakovic V., Cepelak I. еt al. Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects. Eur. J. Pharmacol., 2002, v. 450, p. 277-289.
  54. Ivetic Tkalcevic V., Bosnjak B., Hrvacic B. et al. Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice. Eur. J. Pharmacol., 2006, v. 539, p. 131-138.
  55. Verleden G.M., Vanaudenaerde B.M., Dupont L.J., Van Raemdonck D.E. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am. J. Respir. Crit. Care Med., 2006, v. 174, p. 566-570.
  56. Kozyrskyj A.L., Dahl M.E., Ungar W.J. et al. Antibiotic treatment of wheezing in children with asthma: what is the practice? Pediatrics, 2006, v. 117, p. 1104-1110.
  57. Sacre Hazouri J.A. [Macrolides. Antiinflammatory and immunomodulator effects. Indication in respiratory diseases]. Rev Alerg Mex., 2006, v. 53, p. 108-122.
  58. Richeldi L., Ferrara G., Fabbri L.M. et al. Macrolides for chronic asthma. Cochrane Database Syst. Rev., 2005, No. 4, CD002997.
  59. Daenas C., Hatziefthimiou A.A., Gourgoulianis K.I., Molyvdas P.A. Azithromycin has a direct relaxant effect on precontracted airway smooth muscle. Eur. J. Pharmacol., 2006, v. 553, p. 280-287.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright © Pharmarus Print Media, 2007



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies