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Influence of the Рriorix vaccination on cytokine profile and IgE level in healthy children and patients with atopic dermatitis
- Authors: Toptygina AP1, Alioshkin VA1
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Affiliations:
- G.N. Gabrichevsky Institute of Epidemiology and Microbiology
- Issue: Vol 10, No 3 (2013)
- Pages: 30-34
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/619
- DOI: https://doi.org/10.36691/RJA619
- ID: 619
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Abstract
Background. The aim of the study was to investigate peculiarities of immune responses on the vaccination with Priorix in healthy children and patients with atopic dermatitis. Methods. Thirty five healthy children aged 1-2 years old (Group 1) and 15 children the same age with atopic dermatitis (Group 2) were vaccinated with Priorix. Serum level of IgE was measured by ELISA, and serum concentrations of 7 cytokines: IL-4, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were measured by BioPlex technology before vaccination, 7 days, and 30 days after. Serum level of IgE was measured by ELISA. Results. The level of serum IgE relatively decreased or increased on seventh day after vaccination. In a month IgE level returned back. It was found that in group1 51,4% children demonstrated Th1 type response and 48,6% children showed Th2 type response on the vaccination. Similar distribution was obtained in group 2 (53,3% children showed Th1 type response and 46,7% children demonstrated Th2 type). A significant positive correlation was observed between IgE level increasing and Th2 type of immune response. It was shown that 68,6% of children of group 1 and 66,7% of children of group 2 demonstrated after vaccination the superiority of anti-inflammatory IL-10 over pro-inflammatory TNF-α. We suppose that children with atopic dermatitis can be vaccinated with Priorix.
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About the authors
A P Toptygina
G.N. Gabrichevsky Institute of Epidemiology and Microbiology
Email: toptyginaanna@rambler.ru
Moscow, Russia
V A Alioshkin
G.N. Gabrichevsky Institute of Epidemiology and MicrobiologyMoscow, Russia
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