Exercise-induced asthma: epidemiology, pathogenesis, therapy peculiarities

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Abstract


The article discusses pathogenesis, clinical features and treatment approaches in exerciseinduced asthma and post-exercise bronchoconstriction. Arguments in favor of using antileukotriene medications in complex treatment of patients with exercise-induced bronchoconstriction are presented.

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About the authors

S V Tsarev

Institute of Immunology

Email: SW-tsarev@yandex.ru

References

  1. Rundell K.W., Slee J.B. Exercise and other indirect challenges to demonstrate asthma or exercise induced bronchoconstriction in athlete. J. Allergy Clin. Immunol. 2008, v. 122, р. 238-246.
  2. Weiler J.M., Anderson S.D., Randolph C. Pathogenesis, prevalence, diagnosis, and management of exercise induced bronchoconstriction: a practice parameter. Joint Task Force of the American Academy of Allergy, Asthma and Immunology; the American College of Allergy, Asthma and Immunology and the Joint Council of Allergy, Asthma and Immunology. Ann. Allergy Asthma Immunol. 2010, v. 105, р. 1-47.
  3. Mannix E.T., Roberts M., Fagin D.P. et al. The prevalence of airways hyperresponsiveness in members of an exercise training facility. J. Asthma. 2003, v. 40, р. 349-355.
  4. Mannix E.T., Roberts M.A., Dukes H.J. et al. Airways hyperresponsiveness in high school athletes. J. Asthma. 2004, v. 41, р. 567-574.
  5. Parsons J.P., Kaeding C., Phillips G. et al. Prevalence of exercise-induced bronchospasm in a cohort of varsity college athletes. Med. Sci. Sports Exerc. 2007, v. 39, р. 1487-1492.
  6. Cabral A.L., Conceicao C.M., Fonsecca-Guedes C.M., Martins M.A. Exercise-induced bronchospasm in children: effects of asthma severity. Am. J. Respir. Crit. Care Med. 1999, v. 159, р. 1819-1823.
  7. Weiler J.M., Bonini S., Coifman R. et al. American Academy of Allergy, Asthma & Immunology work group report: exercise-induced asthma. J. Allergy Clin. Immunol. 2007, v. 119, р. 1349-1358.
  8. Becker J.M., Rogers J., Rossini G. et al. Asthma deaths during sports: report of a 7 year experience. J. Allergy Clin. Immunol. 2004, v. 113, р. 264-267.
  9. Parsons J.P., Mastronarde J.G. Exercise induced bronchoconstriction in athletes. Chest. 2005, v. 128, р. 3966-3974.
  10. Scollo M., Zanconato S., Ongaro R. et al. Exhaled nitric oxide and exercise induced bronchoconstriction in asthmatic children. Am. J. Respir. Crit. Care Med. 2000, v. 161, р. 1047-1050.
  11. Carraro S., Corradi M., Zanconato S. et al. Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction. J. Allergy Clin. Immunol. 2005, v. 115, р. 764-770.
  12. Hallstrand T.S., Moody M.W., Aitken M.L. et al. Airway immunopathology of asthma with exercise-induced bronchoconstriction. J. Allergy Clin. Immunol. 2005, v. 116, р. 586-593.
  13. Hallstrand T.S., Wurfel M.M., Lai Y. et al. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010, v. 5, ID e8583.
  14. Anderson S.D., Kippelen P. Airway injury as a mechanism for exercise induced bronchoconstriction in elite athletes. J. Allergy Clin. Immunol. 2008, v. 122, р. 225-235.
  15. Hiltermann T.J., Stolk J., van der Zee S.C. et al. Asthma severity and susceptibility to air pollution. Eur. Respir. J. 1998, v. 11, р. 686-693.
  16. Соодаева С.К., Климанов И.А. Нарушения окислительного метаболизма при заболеваниях респираторного тракта и современные подходы к антиоксидантной терапии. Атмосфера. Пульмонол. и аллергол. 2009, № 1, с. 34-38.
  17. Belda J., Ricart S., Casan P. et al. Airway inflammation in the elite athlete and type of sport. Br. J. Sports Med. 2008, v. 42, р. 244-248.
  18. Chimenti L., Morici G., Paternö A. Bronchial epithelial damage after a half marathon in nonasthmatic amateur runners. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, v. 298, р. 857-862.
  19. Hancox R.J., Subbarao P., Kamada D. et al. Beta2-agonist tolerance and exercise-induced bronchospasm. Am. J. Respir. Crit. Care Med. 2002, v. 165, р. 1068-1070.
  20. Ramage L., Lipworth B.J., Ingram C.G. et al. Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol. Respir. Med. 1994, v. 88, р. 363-368.
  21. Nelson H.S., Weiss S.T., Bleecker E.R. et al. The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006, v. 129, р. 15-26.
  22. Salpeter S.R., Buckley N.S., Ormiston T.M., Salpeter E.E. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann. Intern. Med. 2006, v. 144, р. 904-912.
  23. Nelson J.A., Strauss L., Skowronski M. et al. Effect of longterm salmeterol treatment on exercise-induced asthma. N. Engl. J. Med. 1998, v. 339, р. 141-146.
  24. Kelly K., Spooner C.H., Rowe B.H. Nedocromil sodium vs. sodium cromoglycate for preventing exercise-induced bronchoconstriction in asthmatics. Cochrane Database Syst. Rev. 2000, CD002731.
  25. Sue-Chu M., Karjalainen E.M., Laitinen A. et al. Placebo-controlled study of inhaled budesonide on indices of airway inflammation in broncho-alveolar lavage fluid and bronchial biopsies in cross-country skiers. Respiration. 2000, v. 67, р. 417-425.
  26. Edelman J.M., Turpin J.A., Bronsky E.A. et al. Oral montelukast compared with inhaled salmeterol to prevent exercise induced bronchoconstriction: a randomized, double-blind trial. Exercise Study Group. Ann. Intern. Med. 2000, v. 132, р. 97-104.
  27. Philip G., Pearlman D.S., Villaran C. et al. Reiss T.F. Single-dose montelukast or salmeterol as protection against exercise-induced bronchoconstriction. Chest. 2007, v. 132, р. 875-883.
  28. Rundell K.W., Spiering B.A., Baumann J.M., Evans T.M. Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise. Br. J. Sports Med. 2005, v. 39, р. 232-236.
  29. Storms W., Chervinsky P., Ghannam A.F. et al. A comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge. Respir. Med. 2004, v. 98, р. 1051-1062.

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