The role of atopy patch test with aeroallergens in allergic diseases diagnostics

Cover Page
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


Allergic diseases are increasingly becoming a global epidemic and pose a considerable and growing public health burden. Allergy is a systemic T2-dependent inflammatory reaction to an allergen that results from a complex interaction between genetic and environmental factors. Allergic diseases occur through a T2-dependent type of allergic reaction, some of them, in particular atopic dermatitis (AD) and asthma, develop involving different types of hypersensitivity or their combination and require revision of allergy diagnostics. Atopy patch test (APT) can be informative in establishing a role of cell-mediated hypersensitivity in pathogenesis of allergic diseases.

The review presents the recent data on the significance of APT in the diagnostics of skin and respiratory allergies.


Full Text

Restricted Access

About the authors

Eugeniy V. Smolnikov

NRCI Institute of Immunology FMBA of Russia

Author for correspondence.
Email: qwertil2010@yandex.ru
ORCID iD: 0000-0003-1302-4178

Russian Federation, Moscow

Graduate student in the Department of Skin Allergy and Immunopathology

Alla O. Litovkina

NRCI Institute of Immunology FMBA of Russia

Email: dr.litovkina@gmail.com
ORCID iD: 0000-0002-5021-9276

Russian Federation, Moscow

Graduate student in the Department of Skin Allergy and Immunopathology

Ksenia I. Kolykhalova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kolykhalovaaa@yandex.ru
ORCID iD: 0000-0002-1389-5566

Russian Federation, Moscow

Student

Olga G. Elisyutina

NRCI Institute of Immunology FMBA of Russia

Email: el-olga@yandex.ru
ORCID iD: 0000-0002-4609-2591

Russian Federation, Moscow

Leading researcher of the Department of Skin Allergy and Immunopathology

Elena S. Fedenko

NRCI Institute of Immunology FMBA of Russia

Email: efedks@gmail.com
ORCID iD: 0000-0003-3358-5087
SPIN-code: 5012-7242
Scopus Author ID: 6603386923
ResearcherId: P-6912-2015

Russian Federation, Moscow

Head of the Department of Skin Allergy and Immunopathology

References

  1. Werfel T. The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol. 2009;129:1878–1891. doi: 10.1038/jid.2009.71
  2. Murphy DM, O’Byrne PM. Recent advances in pathophysiology of asthma. Chest. 2010;137:1417–1426. doi: 10.1378/chest.09-1895
  3. Novak N, Bieber T, Kraft S. Immunoglobulin E-bearing antigen-presenting cells in atopic dermatitis. Curr Allergy Asthma Rep. 2004;4:263–269. doi: 10.1007/s11882-004-0069-2
  4. Van Neerven RJ, Knol EF, Ejrnaes A, Wurtzen PA. IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int Arch Allergy Immunol. 2006;141:119–129. doi: 10.1159/000094714
  5. Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016;15(1):35–50. doi: 10.1038/nrd4624
  6. Lloyd CM, Snelgrove RJ. Type 2 immunity: expanding our view. Sci Immunol. 2018;3(25):eaat1604.doi: 10.1126/sciimmunol.aat1604
  7. Campana R, Mothes N, Rauter I, Vrtala S, Reininger R, Focke-Tejkl M, et al. Non-IgE-mediated chronic allergic skin inflammation revealed with rBet v 1 fragments. J Allergy Clin Immunol. 2008;121:528–530. doi: 10.1016/j.jaci.2007.09.014
  8. Khaitov RM, Il’ina NI, editors. Federal′nye klinicheskie rekomendatsii po diagnostike allergicheskikh zabolevanii. Moscow; 2014. (In Russ).
  9. Kapur S, Watson W, Carr S. Atopic dermatitis. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):52.doi: 10.1186/s13223-018-0281-6
  10. Campana R, Moritz K, Marth K, Neubauer A, Huber H, Henning R, et al. Frequent occurrence of T-cell mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments. J Allergy Clin Immunol. 2016;137(2):601–609.e8. doi: 10.1016/j.jaci.2015.08.042
  11. Fuiano N, Diddi G, Delvecchio M, Incorvaia C. Diagnostic performance of the atopy patch test with inhalant allergens. J Investig Allergol Clin Immunol. 2015;25(1):34–39.
  12. Ring J, Kunz B, Bieber T, et al. The “atopy patch test” with aeroallergens in atopic eczema (Abstr.). J Allergy Clin Immunol. 1989;82:195.
  13. Jadassohn J. Zur Kenntnis der medikamentösen Dermatosen, Verhandlungen der Deutschen Dermatologischen Gesellschaft. Fünfter Congress; 1895; Graz. Vienna: Braunmuller; 1896. p. 106.
  14. Mitchell EB, Crow J, Chapman MD, Jouhal SS, Pope FM, Platts-Mills TA. Basophils in allergen-induced patch test sites in atopic dermatitis. Lancet. 1982;1(8264):127–130.
  15. Reitamo S, Visa K, Kähönen K, Käyhkö K, Lauerma AI, Stubb S, et al. Patch test reactions to inhalant allergens in atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1989;144:119–121.
  16. Reitamo S, Visa K, Kähönen K, Käyhkö K, Stubb S, Salo OP. Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens. Br J Dermatol. 1986;114(3):303–309.
  17. Adinoff AD, Tellez P, Clark RA. Atopic dermatitis and aeroallergen contact sensitivity. J Allergy Clin Immunol. 1988;81(4):736–742.
  18. Darsow U, Laifaoui J, Kerschenlohr K, Wollenberg A, Przybilla B, Wuthrich B, et al. The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy. 2004;59:1318–1325.
  19. Darsow U, Vieluf D, Ring J. Evaluating the relevance of aeroallergen sensitization in atopic eczema with the atopy patch test: a randomized, double-blind multicenter study. J Am Acad Dermatol. 1999;40(2 Pt 1):187–193.
  20. doi: 10.1016/s0190-9622(99)70186-6
  21. Darsow U, Wollenberg A, Simon D, Taïeb A, Werfel T, Oranje A, et al. ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol. 2010;24(3):317–328.doi: 10.1111/j.1468-3083.2009.03415.x
  22. Walter A, Seegräber M, Wollenberg A. Food-related contact dermatitis, contact urticaria, and atopy patch test with food. Clin Rev Allergy Immunol. 2019;56(1):19–31.doi: 10.1007/s12016-018-8687-y
  23. Sager N, Feldmann A, Schilling C, Kreitsch P, Neumann C. House dust mite specific T-cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol. 1992;89(4):801–810.
  24. Langeveld-Wildschut EG, Bruijnzeel PL, Mudde GC, Versluis C, Van Ieperen-Van Dijk AG, Bihari IC, et al. Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions. J Allergy Clin Immunol. 2000;105(5):1008–1016.
  25. Fuiano N, Incorvaia C. The atopy patch test: is it time to redefine its significance? Ann Allergy Asthma Immunol. 2011;106(4):278–282. doi: 10.1016/j.anai.2011.01.004
  26. Werfel T, Heratizadeh A, Niebuhr M, Kapp A, Roesner LM, Karch A. Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol. 2015;136(1):96–103.e9.doi: 10.1016/j.jaci.2015.04.015
  27. Wistokat-Wülfing A, Schmidt P, Darsow U, Ring J, Kapp A, Werfel T. Atopy patch test reactions are associated with T-lymphocyte-mediated allergen-specific immune responses in atopic dermatitis. Clin Exp Allergy. 1999;29(4):513–521.
  28. Huss-Marp J, Eberlein-König B, Breuer K, Mair S, Ansel A, Darsow U. Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals. Clin Exp Allergy. 2006;36(3):338–345. doi: 10.1111/j.1365-2222.2006.02448.x
  29. Kerschenlohr K, Decard S, Darsow U, Ollert M, Wollenberg A. Clinical and immunologic reactivity to aeroallergens in “intrinsic” atopic dermatitis patients. J Allergy Clin Immunol. 2003;111(1):195–197.
  30. Guler N, Kirerleri E, Tamay Z, Ones U. Atopy patch testing in children with asthma and rhinitissymptoms allergic to house dust mite. Pediatr Allergy Immunol. 2006;17(5):346–350.
  31. Fuiano N, Incorvaia C, Prodam F, Procaccini DA, Bona G. Relationship between the atopy patch test and clinicale xpression of the disease in children with atopic eczema/dermatitis syndrome and respiratory symptoms. Ann Allergy Asthma Immunol. 2008;101(2):174–178.doi: 10.1016/S1081-1206(10)60206-2
  32. Fuiano N, Fusilli S, Incorvaia C. House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy. Eur J Pediatr. 2010;169(7):819–824.doi: 10.1007/s00431-009-1118-6
  33. Zhao J, Li LF. Atopy patch test to Dermatophagoides mix in a self-selected population in Beijing. Dermatitis. 2013;24(2):82–84.doi: 10.1097/DER.0b013e318284da20
  34. Haselden BM, Kay AB, Larché M. Immunoglobulin E-independent major histocompatibility complex-restricted T-cell peptide epitope-induced late asthmatic reactions. J Exp Med. 1999;189(12):1885–1894. doi: 10.1084/jem.189.12.1885
  35. Fuiano N, Incorvaia C. Utility of the atopy patch test in the diagnosis of allergic rhinitis. Iran J Otorhinolaryngol. 2016;28(86):169–175.

Statistics

Views

Abstract - 18

PDF (Russian) - 0

PlumX

Article Metrics

Metrics Loading ...

Dimensions


Copyright (c) 2021 Russian Journal of Allergy

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies