THE DIAGNOSTIC SIGNIFICANCE OF IMMUNOLOGICAL PARAMETERS OF THE PATIENTS WITH CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

  • Authors: Savlevich EL1, Kurbacheva OM2, Khaidukov SV3, Gerasimov AN4, Amanturlieva ME2, Simbirtcev AS5
  • Affiliations:
    1. Central State Medical Academy of Department for Presidential Affairs of the Russian Federation
    2. NRC Institute of Immunology FMBA of Russia
    3. M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
    4. First Moscow State Medical University (Sechenov University)
    5. State Research Institute of Highly Pure Biopreparations FMBA of Russia
  • Issue: Vol 14, No 4-5 (2017)
  • Pages: 40-45
  • Section: Articles
  • URL: http://rusalljournal.ru/raj/article/view/293
  • Cite item
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Abstract


Background. Investigation of changes in immunological parameters is required to detect the degree of adequate immune system reactions to pathology process and to determine the answer to provided treatment. Taking into account high immunogramm cost differentiated approach is necessary in each specific case basing on economic and diagnostic effectiveness. Now chronic rhinosinusitis with nasal polyps (CRSwNP) is still poorly investigated. In the same clinical situation it is difficult to predict the pathology process development and length of remission period after surgical or conservative treatment. The most substantial difficulties in determining tactics of patients’ management in CRSwNP are associated with asthma, atopy or intolerance to nonsteroidal antiinflammatory drugs (NSAIDs). To determine the diagnostic significance of indicators of systemic cellular immunity for pathology process development forecasting in CRSwNP patients. Methods. CD3, CD4, CD8, CD16, CD19, CD25, CD27, CD45, CD45R0, CD45RA, CD56 and CD127 subpopulations of lymphocytes were examined in peripheral blood of 20 patients (age 46,7±16,06) with bilateral CRSwNP in remission using a flow cytometry method. Results. The study revealed rise in absolute or relative quantity of activated T-lymphocytes (CD3+CD25+), NK cell number (CD3 CD16+CD56+) and T-regulatory (T-reg) cells (CD4+CD25brightCD127lowtoneg), rise in absolute count of memory B-cells (CD19+CD5-CD27+) and NKT-cells (CD16+CD56+CD3+) in CRSwNP patients. An effort to make forecast for the development of CRSwNP due to change in NK (CD3-CD16+CD56+), activated NK (CD3-CD8+) and T-reg (CD4+CD25brightCD127lowtoneg) failed. Conclusion. Study of the cellular immune response to determine the tactics of patients’ management in CRSwNP and predict pathology process development is not a sufficiently informative method.

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E L Savlevich

Central State Medical Academy of Department for Presidential Affairs of the Russian Federation

Email: savllena@gmail.com
21, Marshala Timoshenko str., Moscow, 121359, Russia

O M Kurbacheva

NRC Institute of Immunology FMBA of Russia

24, Kashirskoe shosse, Moscow,115478, Russia

S V Khaidukov

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

16/10, Miklukho-Maklaya str., Moscow, 117997, Russia

A N Gerasimov

First Moscow State Medical University (Sechenov University)

2/4, Bolshaya Pirogovskaya str., Moscow, 119991, Russia

M E Amanturlieva

NRC Institute of Immunology FMBA of Russia

24, Kashirskoe shosse, Moscow,115478, Russia

A S Simbirtcev

State Research Institute of Highly Pure Biopreparations FMBA of Russia

7, Pudozhskaya str., St.-Petersburg, 197110, Russia

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