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Vol 13, No 1 (2016)



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Russian Journal of Allergy. 2016;13(1):3-4
pages 3-4 views

To the question of prenatal predisposing factors to allergic diseases

Lavrova O.V., Dymarskaya Y.R., Petrova M.A., Fedoseev G.B.


Background. To study the peculiarities of pregnancy in asthma women and the health status of their children. Materials and methods. We examined the natural course and outcomes of pregnancy of 1010 women with asthma and monitored health status of their children up to 7 years old. Women were under the observation of pulmonologist and obstetrician throughout the period of gestation; they were treated if necessary and provided with recommendations for the primary prevention of allergic diseases in unborn child. Immediately after delivery children were under the supervision of a pediatrician, allergist. Results. Rising incidence of pregnancy complications in patients with asthma is directly related to the lack of control of the disease, especially in the first trimester of gestation. The lack of adequate treatment of asthma increases the risk of threatened abortion (OR 1,76, CI 0,90-3,47), preeclampsia (OR 2,77, CI 0,94-8,14), placental insufficiency (OR 2,45, CI 1,04-5,87), which has a direct effect on the formation of allergic diseases and, particularly, asthma in their children. Conclusion. Even severe asthma, is not a contraindication for pregnancy. The basic condition for the safety pregnancy and delivery is the adequate medical care that is a set of preventive and therapeutic measures for control of the disease that improve the quality of life of women during gestation and reduce the risk of allergic disease in their children.
Russian Journal of Allergy. 2016;13(1):5-10
pages 5-10 views

The effectiveness of sanatorium and health resort treatment of bronchial asthma patients in the South coast of Crimea depending on the evergreen cypress’s blossoming period

Belyaeva S.N., Savchenko V.M., Govorun M.I., Pirogova M.E.


Background. To study the influence of evergreen cypress blossoming period on the effectiveness of sanatorium and health resort treatment (HRT) of bronchial asthma (BA) patients in the South Coast of Crimea (SCC). Methods. The analysis of the data of 71 patients with BA, the residents of the Crimea was conducted. The survey of BA patients included the questioning, medical observation, physical examination, complete blood count, sputum cytology, lung function examination, motor (physical) abilities by 6 minute steptype test and quality of life. Results. Aeropalinological measurement in the SCC (Yalta) showed that the evergreen cypress’s blossoming period is continuing from February to April inclusive. The highest concentrations of cypress pollen were registered in March and in the first half of April. Efficiency of HRT of BA patients in the SCC did not depend on the pollen season of evergreen cypress. Conclusion. Pollen season of evergreen cypress (February - April inclusive) is not a contraindication for HRT of BA patients in the SCC.
Russian Journal of Allergy. 2016;13(1):11-15
pages 11-15 views

Evaluation of efficacy and safety of intravenous immunoglobulin IG VENA in patients with primary antibody synthesis immunodeficiency

Latysheva E.A., Latysheva T.V., Martynova I.A.


Replacement immunotherapy with intravenous immunoglobulin (IVIG) has been used successfully for the treatment of primary immunodeficiency (PID) for over 60 years. During this time, a huge step forward in purification and manufacturing methods has been made. In addition IVIG therapy has been approved for other diseases and this number is steadily expanding causing an appearance of new IVIG on the pharmaceutical market. These drugs vary in composition, manufacturing technology and, as a consequence, in safety, administration rate, and efficacy. The new IVIG on the Russian market IG Vena was recently introduced. It has already proved its safety and efficacy abroad. This article presents the experience of using the drug IG Vena in adults with PID in immunopathology department of the Institute of Immunology FMBA Russia.
Russian Journal of Allergy. 2016;13(1):16-22
pages 16-22 views

Possibilities of preparation and storage of standard histamine solutions

Prylutskyi A.S., Tkachenko K.Y., Rogovaia Y.D., Abylgazinova N.B.


Background. To explore the stability of histamine solutions of low concentrations sterilized by autoclaving and filtration as well as the possibilities of storage and use of these solutions after 1-fold and 5-fold freezing and defrosting. Methods. Histamine dihydrochloride solutions at a concentration of 10 μg/ml were sterilized by the membrane filtration or the autoclaving at 121 °C for 30 minutes. The solutions were frozen in sterile insulin syringes, followed by 1- and 5-fold defrosting. Skin prick tests have been performed with the resulting solutions. Results. When comparing the results of skin prick testing performed with autoclaved and sterilized by the filtration histamine, no statistically significant differences were found (p>0,05). Comparison of the results of skin prick tests performed with histamine that hadn't been frozen before, after 1- and 5-fold freezing and defrosting showed no statistically significant differences (p>0,05). Conclusion. It has been shown that histamine solutions sterilized by autoclaving at 121 °C for 30 minutes followed by repeated freezing and defrosting don’t change their biological activity substantially.
Russian Journal of Allergy. 2016;13(1):23-26
pages 23-26 views

The efficiency of diet therapy based on amino-acid formula «Neocate Advance»® in treatment of children with severe atopic dermatitis and cow’s milk food allergy. Clinical cases

Elisutina O.G., Shtyrbul O.K., Pampura A.N., Erina O.A., Fedenko E.S.


A food allergy is an abnormal immune response to food, mostly depended on IgE-mediated reactions. One of the most common symptoms of children’s food allergy is atopic dermatitis. The primary goal of diet therapy is the correct choice of hypoallergenic formula. In this article the cases of using amino-acid based formula «Neocate Advance»® in treatment of children with severe atopic dermatitis and cow’s milk food allergy are considered.
Russian Journal of Allergy. 2016;13(1):27-37
pages 27-37 views

Russian Federal clinical recomendations on chronic urticaria diagnostics and treatment

Danilycheva I.V., Ilina N.I., Luss L.V., Fedenko E.S., Shulzhenko A.E.


The revised recomendations on chronic urticaria diagnostics and treatment created by leading Russian experts are presented.
Russian Journal of Allergy. 2016;13(1):38-46
pages 38-46 views

Zinc preparations in atopic dermatits treatment

Elisyutina O.G., Shtyrbul O.V.


The article presents data about the role of such important essential trace element Zinc in the pathogenesis of atopic dermatitis (AD) and the use of zinc - preparations in the complex treatment of AD patients.
Russian Journal of Allergy. 2016;13(1):47-51
pages 47-51 views

Treatment efficacy of the combined medication Allergoferon® during persistent allergic rhinitis

Sotnikova N.Y., Pachomova T.V., Lykova T.A.


Background. To assess the efficacy of a new medication Allergoferon®, gel for topical application, in the treatment of persistent allergic rhinitis Materials and methods. This paper summarizes experience with the combined anti-allergic medication Allergoferon® in the treatment of persistent allergic rhinitis at the manifestation stage in 60 outpatients aged 18 to 75. The study was conducted at outpatient hospitals in the city of Ivanovo in 2014-2015. Symptoms were assessed on the 3rd, 7th, 14th, 21st, 28th and 42nd days, in comparison with the pretreatment period, using patient complaints and clinical and laboratory research data. Results. According to our data, a significant improvement was noted in half of the patients at the 3rd day of treatment, in two-thirds of them - at the 7th day of treatment. In general, improvement of nasal symptoms, compared to the pretreatment period, was noted in all patients at the final visit. The significance of differences was established in 75%. The most positive effect was observed during 7-14 days. Conclusion. A high treatment efficacy of medication Allergoferon® was revealed for patients with allergic persistent rhinitis. The treatment efficacy and the lack of adverse side effects attest to the potential use of this medication in clinical practices.
Russian Journal of Allergy. 2016;13(1):52-56
pages 52-56 views

Efficiency of antihistamine medications for treatment of persistent allergic rhinitis in primary school children: clinical and immunological aspects

Prosekova E.V., Turyanskaya A.I., Netesova S.Y., Sabynych V.A.


Background. Comparative study of clinical and immunological efficiency of systemic [with desloratadine (Aerius®, Bayer n=28)] and topical [with azelastin (Allergodil®, Meda Pharma) n=28] antihistamine single-agent treatment of persistent allergic rhinitis in primary school children (56 children from 6 to 11 years old) was carried out on the basis of monitoring the dynamics of nasal mucosa inflammatory biomarkers (IgE, sIgA, IL-4, IL-8, IL-13, IFN-y, TNFa). Materials and Methods. Questionnaires, selfmonitoring diaries with daily score-based assessment of the symptoms and the score of used pharmacologic agents, nasal discharge and touch smears of nasal cavity mucosa were used as investigative parameters in the study. The study was performed with the permission of the Biomedical Ethics Committee of the State Budgetary Educational Institution of Higher Professional Education «Pacific State Medical University» of the Ministry ofHealth of the Russian Federation. Results. A monthlong therapy with desloratadine enabled clinical control of the symptoms of mild and moderate persistent allergic rhinitis in primary school children in 92,8% of cases and allowed to stop local allergic inflammation intensity as was proved by increasing symptom-free number of days and the fact that symptomatic treatment was not required. The use of desloratadine in the course of the next three months ensured retention of the achieved control. Side and adverse effects in the given group were not registered.
Russian Journal of Allergy. 2016;13(1):57-62
pages 57-62 views

Congresses, Conferences

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Russian Journal of Allergy. 2016;13(1):63-69
pages 63-69 views

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