Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media40110.36691/RJA401Research ArticleEfficiency of antihistamine medications for treatment of persistent allergic rhinitis in primary school children: clinical and immunological aspectsProsekovaE Vpros.ev@mail.ruTuryanskayaA I-NetesovaS Yu-SabynychV A-State Educational Institution of Higher Professional Education «Pacific State Medical University» of the Ministry of Public Health Russian FederationNonprofit Organization «Vladivostok Childhood Asthma Center»15022016131576210032020Copyright © 2016, Pharmarus Print Media2016Background. Comparative study of clinical and immunological efficiency of systemic [with desloratadine (Aerius®, Bayer n=28)] and topical [with azelastin (Allergodil®, Meda Pharma) n=28] antihistamine single-agent treatment of persistent allergic rhinitis in primary school children (56 children from 6 to 11 years old) was carried out on the basis of monitoring the dynamics of nasal mucosa inflammatory biomarkers (IgE, sIgA, IL-4, IL-8, IL-13, IFN-y, TNFa). Materials and Methods. Questionnaires, selfmonitoring diaries with daily score-based assessment of the symptoms and the score of used pharmacologic agents, nasal discharge and touch smears of nasal cavity mucosa were used as investigative parameters in the study. The study was performed with the permission of the Biomedical Ethics Committee of the State Budgetary Educational Institution of Higher Professional Education «Pacific State Medical University» of the Ministry ofHealth of the Russian Federation. Results. A monthlong therapy with desloratadine enabled clinical control of the symptoms of mild and moderate persistent allergic rhinitis in primary school children in 92,8% of cases and allowed to stop local allergic inflammation intensity as was proved by increasing symptom-free number of days and the fact that symptomatic treatment was not required. The use of desloratadine in the course of the next three months ensured retention of the achieved control. Side and adverse effects in the given group were not registered.allergic rhinitisprimary school childrentreatmentdesloratadineаллергический ринитмладшие школьникитерапиядезлоратадин[Global atlas of allergic rhinitis and chronic rhinosinusitis. Published by the European Academy of Allergy and Clinical Immunology. Editors Cezmi A. Akdis, Peter W. Hellings, Ioana Agache. Published by the European Academy of Allergy and Clinical Immunology, Switzerland, 2015, 444 p.][Roberts G., Xatzipsalti M., Borrego L.M. et al. Pediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013, v. 68, p. 1102-1116.][Michael C.F., Tong Janice S.C. Lin. Epidemiology of allergic rhinitis throughout the world. Global atlas of allergic rhinitis and chronic rhinosinusitis. Published by the European Academy of Allergy andClinical Immunology. Switzerland, 2015, р. 62-63.][РАДАР. Аллергический ринит у детей. Рекомендации и алгоритм при детском аллергическом рините. Научно-практическая программа. Под редакцией В.А. Ревякиной, Н.А. Дайхес, Н.А. Геппе. М., «Оригинал-макет». 2015, 80 с.][Ревякина В.А. Эпидемиология аллергических заболеваний у детей и организация педиатрической аллергологической службы в России. Научно-практический журнал «Педиатрия» им. Г.Н. Сперанского. 2003, № 4, с. 47-52.][Потатуркина-Нестерова Н.И., Нестерова А.В. Особенности течения аллергических ринитов у детей при сочетании с бронхиальной астмой. Изд-во ТГУ, Тольятти. 2012, 140 с.][Хаитов Р.М., Ильина Н.И. Аллергология. Федеральные клинические рекомендации «Фармарус Принт Медиа». М., 2014, 126 с.][Дробик О.С., Наусова А.Ю. Аллергический ринит: взгляд аллерголога. Вестн. оториноларингол. 2014, № 2, с. 82-85.][Данилова К.В, Раздорская И.М. Терапия аллергического ринита: предпочтения специалистов. Вестн. оториноларингол. 2014, № 3, с. 59-60.][Касохов Т.Б. Павловская Л.В., Цораева З.А., Касохова В.В. Современные подходы к терапии аллергического ринита у детей. Международный журнал прикладных и фундаментальных исследований. 2012, № 2, с. 44-46.]