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Vol 13, No 2 (2016)

Articles
Asthma induced by physical effort - the problem of a large sports and not only
Glushkova E.F., Surovenko T.N., Shartanova N.V., Krasnova J.N.
Abstract
For many decades it was thought that exercise can only have a positive impact on health. However, increasingly there are publications over the past few years that this view is mistaken. The article presents data on asthma physical effort, its impact on the condition of the respiratory tract, preventive and medical methods to combat it.
Russian Journal of Allergy. 2016;13(2):3-9
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Modern view on immunopathogenesis of asthma
Kurbacheva O.M., Zhestkov A.V., Nagatkin D.A., Kulagina V.V., Nagatkina O.V.
Abstract
The modern approaches to the understanding of inflammation in the lower airways in asthma are discussed in the article. we present some recent studies that demonstrate the variety of mechanisms of the inflammatory response and the heterogeneity of patients with bronchial asthma. the immunological particularities of asthma endotypes and phenotypes are shown in this article.
Russian Journal of Allergy. 2016;13(2):10-14
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The compensatory reactions of the immune system in patients with a defect of antibodies synthesis - agammaglobulinemia
Sizyakina L.P., Andreeva I.I.
Abstract
In the present study, we describe changes in the immune state of patients with X-linked agammaglobulinemia (X-AGG). We observed the dynamic of the cellular component of the immune system of adaptive and cellular and humoral components of the innate immunity. We investigated parameters of the maturation, differentiation, activation of T-lymphocytes, NK-cells, monocytes, cytokines, antimicrobial peptides in the peripheral blood of these patients. We found the compensatory activation of the effectors systems. We observed decrease of CD4+Foxp3+cells, elevation of the activation functions of T-cells. Microbicidial activity of neutrophils was decreased.
Russian Journal of Allergy. 2016;13(2):15-18
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Eosinophilic esophagitis and allergic rhinitis with sensitization to indoor allergens as a comorbid diseases
Vorzheva I.I., Neustroev V.G., Raevskaya L.Y., Chernyak B.A.
Abstract
Eosinophilic esophagitis (EE) is a chronic disease characterized by antigen-mediated eosinophilic inflammation leading to esophageal dysfunction. Food and pollen allergens are considered to be the main cause of EE. Indoor allergens can offend EE but not so often as food and pollen. Clinical case of EE associated with persistent allergic rhinitis with sensitization to house dust mites and cockroaches is presented in the article. Successful treatment with inhaled topical corticosteroids, taken orally, confirmed by endoscopy and biopsy is demonstrated.
Russian Journal of Allergy. 2016;13(2):19-22
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Urticaria is not a sentence. The clinical cases
Danilycheva I.V., Shulzhenko A.E., Bondarenko N.G.
Abstract
Omalizumab - monoclonal therapeutic antibody to human IgE, is effectively used for the treatment of patients with chronic spontaneous urticaria (HSC), refractory to 4 times increased doses of antihistamines. The article describes two cases of effective treatment of patients (HSC) with omalizumab (Xolair® «Novartis Pharma» LLC) after a long period of unsuccessful therapy with H1-antihistamines, leukotriene receptor antagonists, and corticosteroids.
Russian Journal of Allergy. 2016;13(2):23-26
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Predictive model of development of atopic dermatitis in children
Levashcva S.V., Etkina E.I., Fazylova A.A., Sakaeva G.D., Babenkova L.I., Orlova N.A.
Abstract
Background. To identify the set of possible predictors of atopic dermatitis forming in children. Methods. There were 440 children aged from 0 to 18 years old (315 patients with atopic dermatitis, 125 - children of the monitoring group) under investigation. Mathematical models used logistic regression method were developed. Results. On the basis of the obtained data the logistic regression equation was selected, including 16 predictors, statistical significance of which was within 5% of the Wald statistics. Conclusion. Practical application of the devised formula will help to identify children with high risk to develop atopic dermatitis.
Russian Journal of Allergy. 2016;13(2):27-31
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VDR gene polymorphism in children with allergic diseases
Sentsova T.B., Vorozhko I.V., Chernyak O.O., Revyakina V.A., Timofeeva A.M., Mukhortyh V.A., Donnikov A.E.
Abstract

Background. To investigate the frequency of vitamin receptor gene D (VDR) polymorphism in children with allergic diseases. Materials and methods. We enrolled 130 children (66 boys and 64 girls) with allergic diseases aged from 1,5 to 16 years old. All children underwent clinical and allergological examination. 93 children (71,5%) had isolated allergy, mainly food allergy and atopic dermatitis, 37 children (28,4%) had bronchial asthma, associated with allergic rhinitis and urticaria. The control group included 41 healthy children aged from 1 to 10 years old. For DNA allotment the kit «ProbaRapid Genetics» of «DNA Technology» (Russia) was used. Analysis of polymorphic marker FokI (rs 2228570), BsmI (rs 1544410) and TaqI (rs 731236) of VDR gene was performed by PCR in real time using the detecting thermocycler DT-96, and kits for DNA diagnostics company «DNA technology» (Russia). Research metabolite 25-OH (25-hydroxyvitamin D2 and D3) of vitamin D was carried out by ELISA commercial kit «DIAsource» (Belgium). Results. Significantly increased frequency of allele A in the VDR gene BsmI site (OR=1,81, p=0,04) and homozygous A/A, heterozygous G/A genotype (OR=2,03, p=0,05 and OR=1,8, p=0,05, respectively) was found, that enables to consider it as a prognostic marker associated with the development of allergic disease risk. Statistically significant reduction in the concentration of 25-OH-vitamin D (p=0,02) in children with the heterozygous variant A/G and homozygous G/G in Fok1 VDR gene was found. Conclusion. There were significant differences in frequencies of genotypes and alleles of DVR gene in children with allergic diseases in the population. These results create the preconditions for the development of new methods of prevention of vitamin D deficiency, taking into account the individual characteristics of its metabolism.

Russian Journal of Allergy. 2016;13(2):32-35
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Allergic rhinitis is a seasonal trouble and off-seasonal problem
Fedoskova T.G., Svistushkin V.M., Shevchik E.A.
Abstract
Rhinitis (allergic, vasomotor and others) is common inflammatory disease of the nasal cavity. Clinical manifestations of chronic rhinitis, such as nasal obstruction, discharge from the nasal cavity, significantly reduce the quality of life of the patients. Efficacy of modern antihistamine - azelastin in the treatment of seasonal and perennial allergic rhinitis is presented in the article.
Russian Journal of Allergy. 2016;13(2):36-43
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Efficacy and safety of montelukast in patients with asthma and allergic rhinitis in routine clinical practice: results of a prospective multicenter observational program
Sidorenko I.V., Zahargevskaya T.V.
Abstract
Background. To evaluate efficacy and safety of montelukast in the treatment of adult patients with asthma, allergic rhinitis or with combination of asthma and allergic rhinitis in routine clinical practice. Methods. The open-label, single-arm, prospective, multicenter observational program. No specific procedures beyond routine clinical practice were performed. Data collection was performed at baseline (at the enrollment in the program) as well as after the end of the prescribed course of treatment with montelukast Actavis, but not more than at 12 weeks of treatment. The study included 545 patients. Criteria for efficacy: the frequency of the daytime and nocturnal symptoms of asthma needs the rescue medications, the number of exacerbations during the last 3 months (hospitalizations, calls for specialized medical care), change of the nasal symptoms score (TNSS). Results. After 12 weeks of therapy, the proportion of patients who maintained daily asthma symptoms, decreased by 3,4 times and amounted to only 22% compared to 75,2% at baseline. Especially significant, 4,3-fold, reduced the number of patients with nocturnal symptoms - from 61,8% to 14,4%. The need to use drugs emergency and restriction of activities associated with asthma symptoms also decreased by 3,6 and 3,2 times, respectively. Conclusion. The use of montelukast Actavis in patients with asthma, AR and a combination of asthma and AR is efficient, safe, and helps to improve the control of asthma symptoms and the AR; the improvement of the general condition of patients, as well as reduction of the percentage of eosinophils in the blood was shown. The drug is well tolerated and is convenient for patients.
Russian Journal of Allergy. 2016;13(2):44-53
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The effectiveness of intranasal corticosteroids and antihistamines combination - mometasone furoate and azelastine hydrochloride nasal spray in adults with seasonal allergic rhinitis (The results of clinical trial)
Nenasheva N.M., Ilina N.I., Fedoskova T.G.
Abstract
Background. Intranasal corticosteroids and antihistamines are the basis of pharmacotherapy of allergic rhinitis (AR). The aim of this study was to evaluate the efficacy, safety and tolerability of Momat Rhino Advance (fixed combination of azelastine hydrochloride 140 mcg + mometasone furoate 50 mcg) intranasal spray in seasonal rhinitis patients. Materials and methods. Momat Rhino Advance was administered within 14 days in adults with seasonal AR in comparison with the original azelastine hydrochloride and mometasone furoate, used in combination with each other from separate devices against nasal (TNSS) and non-nasal (TNNSS) rhinitis symptoms. In total, 220 patients 18-65 years old with moderate/severe seasonal AR, were randomized in an open, parallel-group, multicenter clinical trial conducted in 16 centers in the Russian Federation during the period from April to September 2014. Results and conclusion. As a result of the study a marked decreasing of nasal symptoms using scale TNSS (in 89,6% relatively to the initial visit, p<0,05), and non-nasal symptoms using scale TNNSS (in 92,8% relatively to the initial visit, p<0,05) was obtained. Quality of life index using a standardized questionnaire RQLQ, showed a significant positive trend in treated patients with AR (p<0,05). There were no differences between the main group and other groups of patients in relation to nasal and other symptoms of seasonal AR and quality of life index. All studied drugs have shown high level of safety and tolerability. Thus, there was no difference between Momat Rhino Advance (fixed combination of azelastine hydrochloride 140 mcg + mometasone furoate 50 mcg, Glenmark Pharmaceuticals Ltd., India) nasal spray efficacy and safety in comparison with azelastine hydrochloride - nasal spray, and mometasone furoate nasal spray, applied from the individual devices in seasonal allergic rhinitis patients. The optimum regimen of using of Momat Rhino Advance was twice daily.
Russian Journal of Allergy. 2016;13(2):54-64
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Congresses, Conferences
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Russian Journal of Allergy. 2016;13(2):65-71
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