Helicobacter pylori infection: regulatory role of cytokines in inflammation and allergy



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Abstract

Helicobacter pylori is a Gram-negative bacterium that chronically infects the stomach of more than 50% of human population and represents the major cause of gastroduodenal pathologies. The H. pylori infection is followed by local inflammatory response in gastric mucosa and proinflammatory cytokine production, and preferably elicits a T-helper 1 (Thl) immune response. Bronchial asthma and allergic diseases are orchestrated by Th2 cytokines. A negative association between the H. pylori infection and frequency of allergic diseases was found. Investigations of possible molecular mechanisms of the association are required for research of novel strategies of prevention and treatment of allergic diseases.

About the authors

E A Varyushina

State Scientific Center State Research Institute of Highly Pure Biopreparations

Email: elenavaryush@gmail.com
State Scientific Center State Research Institute of Highly Pure Biopreparations

A S Simbirtsev

State Scientific Center State Research Institute of Highly Pure Biopreparations

State Scientific Center State Research Institute of Highly Pure Biopreparations

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