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Use of Broncho-Munal after measles vacc ination inkids with recu rrent infections
- Authors: Kharit SM1, Nacharova EP1, Kaplina SP1, Monakhova NE1, Goleva OV1, Kharit SM2, Nacharova EP2, Kaplina SP3, Monahova NE2, Goleva OV2
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Affiliations:
- Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»
- Saint-Petersburg health care facility «Specialized neuropsychiatric orphanage № 13 Admiraltydistrict of St. Petersburg»
- Issue: Vol 8, No 5 (2011)
- Pages: 37-44
- Section: Articles
- Submitted: 10.03.2020
- Published:
- URL: https://rusalljournal.ru/raj/article/view/795
- DOI: https://doi.org/10.36691/RJA795
- ID: 795
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Abstract
from the day 1 till the day 30 after measles vaccination. The control group of 29 kids of the same age did not
receive any immunomodulatory therapy after the vaccination. 12 out of 15 (80%) kids in the Broncho-munal
group developed no complications after the vaccination compared with 20 out of 29 kids (68,9%) in the control
group. The frequency of intercurrent infections was 3,5 times lower in the Broncho-munal group. The kids in
the Broncho-munal group developed neither lymphopenia nor leukopenia. They had increased counts of CD25+
and CD20+ cells by the day 30 after the vaccination, prolonged production of the specific antibodies as well as
higher geometric mean titers of the anti-measles antibodies on the day 45 after the vaccination. Taken together
these observations suggest that Broncho-munal protected from the transitory immunosuppressive effects of
the vaccination.
About the authors
S M Kharit
E P Nacharova
Email: aranel@list.ru
S P Kaplina
N E Monakhova
O V Goleva
S M Kharit
Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»
E P Nacharova
Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»
S P Kaplina
Saint-Petersburg health care facility «Specialized neuropsychiatric orphanage № 13 Admiraltydistrict of St. Petersburg»Saint-Petersburg health care facility «Specialized neuropsychiatric orphanage № 13 Admiraltydistrict of St. Petersburg»
N E Monahova
Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»
O V Goleva
Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»Federal State Institution «Scientific Research Institute for childhood infections of the FederalMedical-Biological Agency»
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