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Regulat ory T-cells in periphera l blood of pat ientswith br onchial ast hma
- Authors: Kremer EE1, Kirillova NA1, Teplova NV1, Deev IA1, Petrova IV1, Ogorodova LM1, Kremer EE2, Kirillova NA2, Teplova NV2, Deev IA2, Petrova IV2, Ogorodova LM2
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Affiliations:
- Siberian State Medical University
- Issue: Vol 8, No 5 (2011)
- Pages: 21-25
- Section: Articles
- Submitted: 10.03.2020
- Published:
- URL: https://rusalljournal.ru/raj/article/view/781
- DOI: https://doi.org/10.36691/RJA781
- ID: 781
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Abstract
T-cells (Treg) in patients with different severity of bronchial asthma (BA).
Methods. We included 19 patients with severe BA, 12 patients with mild BA and 17 healthy donors. The circulating
percentage of CD4+CD25high and CD4+FoxP3+ T-reg in peripheral blood was estimated by the flow cytometry
analysis (FACSCalibur, Becton Dickinson, USA).
Results. Numbers of peripheral blood CD4+CD25high was significantly decreased in mild BA compared to healthy
control. Patients with severe BA had increased levels of CD4+FoxP3+ and CD4+CD25high compared to mild BA.
Conclusion. Our results demonstrate new scientific data on the phenotypic characteristics and the level of T-reg
in peripheral blood at different clinical forms of asthma. This fact confirms the existence of immunoregulatory
control mechanisms of allergic inflammation involving T-reg.
About the authors
E E Kremer
Email: elenakremer@yandex.ru
N A Kirillova
N V Teplova
I A Deev
I V Petrova
L M Ogorodova
E E Kremer
Siberian State Medical UniversitySiberian State Medical University
N A Kirillova
Siberian State Medical UniversitySiberian State Medical University
N V Teplova
Siberian State Medical UniversitySiberian State Medical University
I A Deev
Siberian State Medical UniversitySiberian State Medical University
I V Petrova
Siberian State Medical UniversitySiberian State Medical University
L M Ogorodova
Siberian State Medical UniversitySiberian State Medical University
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