Regulat ory T-cells in periphera l blood of pat ientswith br onchial ast hma



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Abstract

Background. To investigate the expression of surface molecules CD4+CD25high and CD4+FoxP3+ on regulatory
T-cells (Treg) in patients with different severity of bronchial asthma (BA).
Methods. We included 19 patients with severe BA, 12 patients with mild BA and 17 healthy donors. The circulating
percentage of CD4+CD25high and CD4+FoxP3+ T-reg in peripheral blood was estimated by the flow cytometry
analysis (FACSCalibur, Becton Dickinson, USA).
Results. Numbers of peripheral blood CD4+CD25high was significantly decreased in mild BA compared to healthy
control. Patients with severe BA had increased levels of CD4+FoxP3+ and CD4+CD25high compared to mild BA.
Conclusion. Our results demonstrate new scientific data on the phenotypic characteristics and the level of T-reg
in peripheral blood at different clinical forms of asthma. This fact confirms the existence of immunoregulatory
control mechanisms of allergic inflammation involving T-reg.

About the authors

E E Kremer

Email: elenakremer@yandex.ru

N A Kirillova

N V Teplova

I A Deev

I V Petrova

L M Ogorodova

E E Kremer

Siberian State Medical University

Siberian State Medical University

N A Kirillova

Siberian State Medical University

Siberian State Medical University

N V Teplova

Siberian State Medical University

Siberian State Medical University

I A Deev

Siberian State Medical University

Siberian State Medical University

I V Petrova

Siberian State Medical University

Siberian State Medical University

L M Ogorodova

Siberian State Medical University

Siberian State Medical University

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