Triggernye faktory khronicheskogoretsidiviruyushchego polipoznogorinosinusita



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Abstract

Обзор посвящен патогенетическим аспектам хронического рецидивирующего полипозного риносинусита
(ХРПР ). Рассматриваются аргументы в пользу «грибковой» и «стафилококковой» гипотез. Обсуждаются
факты, противоречащие теории об инфекционной природе ХРПР . Отражены основные иммунологические
нарушения при полипозе носа: дисфункция металлопротеиназ, циклооксигеназного цикла, гипрепродукция
IL-5, IL-16 с последующим развитием эозинофильного воспаления. С учетом разнообразия клинических
проявлений хронического риносинусита предполагается, что только многофакторный анализ триггерных
факторов может пролить свет на патогенез этого заболевания.

About the authors

M A Mokronosova

Email: mmokronosova@mail.ru

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