Osobennosti sekretornogo immunitetazheludochno-kishechnogo trakta



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Abstract

В обзоре описаны структура и функции слизистой оболочки желудочно-кишечного тракта (ЖКТ), основные
компоненты слизистого барьера, включая иммуноглобулины, муцины и антимикробные пептиды.
Отмечена роль комменсальной микрофлоры. Рассмотрена структура лимфоидной ткани кишечника
(GALT), ее основные клеточные элементы, осуществляющие надзор врожденного иммунитета за
гомеостазом в слизистой оболочке ЖКТ и контролирующие оральную толерантность. Представлены
иммунорегуляторы адоптивного иммунного ответа (Th1, Th2 и Th17), ответственные за срыв толерантности,
развитие пищевой аллергии, аутоиммунитета и хронического воспаления кишечника.

Keywords

References

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