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Atopic dermatitis in children and specific IgE to Stahpylococcus aureus superantigens: a compare with disease severity
- Authors: Treneva MS1, Pampura AN1, Okuneva TS1
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Affiliations:
- Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
- Issue: Vol 9, No 4 (2012)
- Pages: 39-41
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2012
- URL: https://rusalljournal.ru/raj/article/view/703
- DOI: https://doi.org/10.36691/RJA703
- ID: 703
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Abstract
Background. Staphylococus aureus (S. aureus ) function in atopic dermatitis (AD) children skin is double-handed: an infectious trigger and an allergen. The study was aimed to evaluate a frequency of S. aureus enterotoxins IgE work out in children with infected AD skin and to compare IgE levels with infected AD severity. Methods. Specific IgE to S. aureus enterotoxins A and B (ImmunoCap, Phadia AB, Sweden) detected in serum of 90 children with infected AD. IgE levels were compared to severity of infected AD (Mann—Whitney Utest). Results. Specific IgE>0,35 kUA/l to S. aureus enterotoxin A frequency was of 0,29; to enteritoxin B 0,36; to one of them 0,43. IgE to S. aureus enterotoxins were elevated in 16 children with therapy resistant AD in compare to other cases of AD (р=0,00183). Conclusion. In children with infected AD S. aureus enterotoxins A or/and B are revealed in 25—50% of cases. In children with therapy resistant AD specific IgE level to enterotoxins is elevated in comparison to severe or average AD children.
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About the authors
M S Treneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
Email: trenevamarina@mail.ru
A N Pampura
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
T S Okuneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
References
- Leuden J.J., Marples R.R., Kligman A.M. Staphylococcus aureus in the lesions of atopic dermatitis. Br. J. Dermatol. 1974, v. 90, p. 525-530.
- Hauser C., Prins C., Lacour M. The role of infection agents in atopic dermatitis. In: Leung D.Y.M., ed. Atopic dermatitis: from pathogenesis to treatment. Ney York: Chapman & Hall. 1996, p. 67-112.
- Елисютина О.Г., Феденко Е.С. Роль Staphylococcus aureus в патогенезе атопического дерматита. Рос. Аллергол. Журн. 2004, № 1, с. 17-22.
- Hauk P.J., Leung D.Y. Takrolimus (FK506): new treatment approach in superantigen-associated diseases like atopic dermatitis? J. Allergy Clin. Immunol. 2001, v. 107, p. 391-392.
- Воронина В.Р., Феденко Е.С., Пампура А.Н. Влияние колонизации кожи стафилококком и выделяемых им суперантигенов на течение атопического дерматита у детей. Рос. Аллергол. Журн. 2004, № 3, с. 36-42.
- Bunikowski R., Mielke M., Skarabis H. et al. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus derived superantigens SEA and SEB in children with atopic dermatitis. J. Allergy Clin. Immunol. 1999, v. 103, p. 119-124.
- Nomura I., Tanaka K., Tomita H. et al. Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. J. Allergy Clin. Immunol. 1999, v. 104, p. 441-446.
- Gong J.Q., Line L., Line T. et al. Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial. Br. J. Dermatol. 2006, v. 155 (4), p. 680-687.
- Akdis C. A., Akdis M., Bieber T. et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. The Journal of Allergy and Clinical Immunology. 2006, v. 118 (1), p. 152-169.
- Schuttelaar M.L., Coenraads P.J. A randomized, double-blind study to assess the efficacy of addition of tetracycline to triamcinolone acetonide in the treatment of moderate to severe atopic dermatitis. J. Eur. Acad. Dermatol. Venereol. 2008, v. 22 (9), p. 1076-1082.
- Herbert S., Barry P., Novick R.P. Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus. Infect. Immun. 2001, v. 69, p. 2996-3003.
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