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Antibiotic resistance of Staphylococcus aureus in children with atopic dermatitis in 2002-2004 versus 2007-2009 years
- Authors: Treneva MS1, Pampura AN1, Voronina VR1, Zaporozhtseva ZV1
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Affiliations:
- Federal State Institution «Moscow Research Institute of pediatrics and child surgery by Ministry of Health & Social Welfare»
- Issue: Vol 9, No 3 (2012)
- Pages: 23-26
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2012
- URL: https://rusalljournal.ru/raj/article/view/699
- DOI: https://doi.org/10.36691/RJA699
- ID: 699
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Abstract
Background. Staphylococus aureus (S. aureus) colonization is revealed in 80-84% of patients with atopic dermatitis (AD). There are no results on S. aureus susceptibility to antibiotics in children with AD within the period 2002-2004 to 2007-2009 years. Methods. S. aureus susceptibility to antibiotics was evaluated in 62 children with AD in 2002-2004 years and in 199 children in 2007-2009 years. S. aureus susceptibility and resistance to antibiotics were evaluated as frequencies (q) and their 95% confidential intervals (CI 95%) with MS «Excell». results. S. aureus antibiotic susceptibility in AD children is increased to ciprofloxacin since 2002-2004 to 2007-2009 [0,54 (0,42..0,67) /0,85 (0,80..0,91)] and is not changed to ceftriaxone [0,57 (0,44..0,70) /0,64 (0,57..0,71)], oxacillin [0,75 (0,64..0,86)/0,71 (0,64..0,78)] and cefuroxime [0,61 (0,49..0,74)/0,58 (0,36..0,80)]. Erythromycin susceptibility of S. aureus is 7 times reduced [0,71 (0,60..0,82)/0,10 (0,06..0,14)]; chloramphenicol susceptibility is 2 times reduced [0,79 (0,69..0,90)/0,33 (0,09..0,57)]. There is a decline of S. aureus antibiotic susceptibility to penicillin, ampicillin, linkomycin. Conclusion. Ceftriaxone may be the antibiotic of choice in children with severe infected AD. Oxacillin and cefuroxime should be recommended as an alternative choice.
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About the authors
M S Treneva
Federal State Institution «Moscow Research Institute of pediatrics and child surgery by Ministry of Health & Social Welfare»
Email: trenevamarina@mail.ru
A N Pampura
Federal State Institution «Moscow Research Institute of pediatrics and child surgery by Ministry of Health & Social Welfare»
V R Voronina
Federal State Institution «Moscow Research Institute of pediatrics and child surgery by Ministry of Health & Social Welfare»
Z V Zaporozhtseva
Federal State Institution «Moscow Research Institute of pediatrics and child surgery by Ministry of Health & Social Welfare»
References
- Leyden J.E., Marples R.R., Kligman A.M. Staphylococcus aureus in the lesions of atopic dermatitis. Br. J. Dermatol. 1974, v. 90, p. 525-530.
- Goodyear H.M., Watson P.J., Egan S.A. et al. Skin microflora of atopic eczema in first time hospital attenders. J. Clin. Exp. Dermatol. 1993, v. 18 (4), p. 300-304.
- Gong J.Q., Lin L., Lin T., Hao F., Zeng F.Q., Bi Z.G. et al. Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial. Br. J. Dermatol. 2006, v. 155 (4), p. 680-687.
- Leung A.D., Schiltz A.M., Hall C.F., Liu A.H. Severe atopic dermatitis is associated with a high burden of environmental Staphylococcus aureus. Clin. Exp. Allergy. 2008, v. 38, p. 789-793.
- Kedzierska A., Kapiсska-Mrowiecka M., Czubak-Macugowska M. et al. Susceptibility testing and resistance phenotype detection in Staphylococcus aureus strains isolated from patients with atopic dermatitis, with apparent and recurrent skin colonization. Br. J. Dermatol. 2008, v. 159 (6), p. 1290-1299.
- Suh L., Coffin S., Leckerman K.H. et al. Methicillin-resistant Staphylococcus aureus colonization in children with atopic dermatitis. Pediatr. Dermatol. 2008, v. 25 (5), p. 528-534.
- Bonness S., Szekat C., Novak N. et al. Pulsed-field gel electrophoresis of Staphylococcus aureus isolates from atopic patients revealing presence of similar strains in isolates from children and their parents. J. Clin. Microbiol. 2008, v. 46 (2), p. 456-461.
- Ortega-Loayza A.G., Diamantis S.A., Gilligan P., Morrell D.S. Characterization of Staphylococcus aureus cutaneous infections in a pediatric dermatology tertiary health care outpatient facility. J. Am. Acad. Dermatol. 2010, v. 62 (5), p. 804-811.
- Страчунский Л.С., Дехнич А.В., Белькова Ю.А. и соавт. Сравнительная активность антибактериальных препаратов, входящих в лекарственные формы для местного применения, в отношении Staphylococcus aureus: результаты российского многоцентрового исследования. Клин. микробиол. и антимикр. химиотер. 2002, № 2, c. 157-163.
- Дехнич А.В., Эйдельштейн И.А., Нарезкина А.Д. и соавт. Эпидемиология антибиотикорезистентности нозокомиальных штаммов Staphylococcus aureus в России: результаты многоцентрового исследования. Клин. микробиол. и антимикр. химиотер. 2002, № 4, с. 325-336.
- Ewing C.I., Ashcroft C., Gibbs A.C.C. et al. Flucloxacillin in the treatment of atopic dermatitis. Br. J. Dermatol. 1998, v. 138, p. 1022-1029.
- Vollmert C., Behrendt H. Bacterial activity of flucloxacillin against Staphylococcus aureus in primary keratinocyte cultures of lesional and unaffected skin of patients suffering from atopic dermatitis. Exp. Dermatol. 2005, v. 14, p. 215-24.
- Boguniewicz M., Sampson H., Leung S.B. et al. Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis. J. Allergy Clin. Immunol. 2001, v. 108, p. 651-652.
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