BIOMARKERS ALLERGIC INFLAMATION AND SEVERITY OF ATOPIC DERMATITIS AT CHILDREN



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Abstract

Background.To establish the relationship between the serum concentrations of IL4, IL5, eotaxin, eotaxin2, ECP and the severity of atopic dermatitis in children. Methods. The study included 40 children with atopic dermatitis, patients were divided into two clusters with KMeans method, index SCORAD was taken as a criterion of clustering. All patients were conducted to determine the concentration of IL4, IL5, eotaxin, eotaxin2, ECP. Results. The SCORAD index was significantly higher in the second cluster in comparison to the first one. In second cluster the level of eotaxin2 was significantly higher, in terms of the ECP, IL4, IL5,eotaxin patient groups did not differ. The second cluster was characterized by patients with a concentration of IL5 of 1,5 p/ml. Conclusion. In assessing the severity of allergic inflammation in atopic dermatitis concentration of eotaxin2 was most informative.

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About the authors

E E Varlamov

Moscow Research Institute of Pediatrics and Child Surgery

T V Vinogradova

Moscow Research Institute of Pediatrics and Child Surgery

A A Chuslyaeva

Moscow Research Institute of Pediatrics and Child Surgery

T S Okuneva

Moscow Research Institute of Pediatrics and Child Surgery

A N Pampura

Moscow Research Institute of Pediatrics and Child Surgery

Email: apampura@pedklin.ru

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