Preexposure prophylaxis of infants’ food allergy

  • Authors: Denisova SN1,2, Belitskaya MY.2, Sentsova TB3, Revyakina VA3, Kirillova OO3, Vorozhko IV3
  • Affiliations:
    1. Russian National Medical and Research university named after N.I. Pirogov
    2. Infant City Clinical Hospital No. 9 named after G.N. Speransky
    3. Federal State Institute «Research and Development Establishment of Russian Academy of Medical Sciences»
  • Issue: Vol 10, No 2 (2013)
  • Pages: 37-42
  • Section: Articles
  • URL: https://rusalljournal.ru/raj/article/view/620
  • DOI: https://doi.org/10.36691/RJA620
  • Cite item
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Abstract


Background. Till the present time the problem of food allergy remains to be the topical subject and demands further development of therapeutical and prevention programs, including diet therapy for nursing mothers. The work is aimed at clinical and immunological evaluating of diet therapy of mothers whose children have atopic dermatitis on the back of breast feeding only. Methods. There were 100 «mother and child» couples kept under observance, that were divided into two groups. All the children had atopic dermatitis (AD), associated to cow milk protein allergy. Nursing mothers from both the groups were treated by diet therapy according to which the cow milk in diet have been replaced either with goat milk of New Zealand origin (first group had 43 «mother and child» couples) or with nondairy products (second group had 57 «mother and child» couples). Effectiveness of diet therapy of nursing mothers has been evaluated by the dynamic of clinical and immunological symptoms of atopic dermatitis in 1-3 months from treatment beginning. Immunological effectiveness of the treatment has been evaluated by the dynamic of indexes of specific IgE and IgG antibodies to cow milk protein, β-lactoglobulin, casein, soy protein and goat milk protein and cytokines levels. Results. In the course of treatment, that included diet therapy of nursing mothers and antiallergic cure of infants, both the groups showed remission and saved breast feeding. Immunological evaluating of therapeutic intervention’s effectiveness revealed the improvement of total IgE, allergenspecific IgE and IgG antibodies to cow milk protein and its fractions, as well as to soy and goat milk protein in blood of all the children on the back of breast feeding. Moreover, complex therapy conduced decreasing of pro-inflammatory cytokines concentration in blood. Conclusion. These findings prove reasonability of dietary treatement for nursing mothers, whose children have atopic dermatitis, associated associated to cow milk protein allergy.

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S N Denisova

Russian National Medical and Research university named after N.I. Pirogov; Infant City Clinical Hospital No. 9 named after G.N. Speransky

M Yu Belitskaya

Infant City Clinical Hospital No. 9 named after G.N. Speransky

T B Sentsova

Federal State Institute «Research and Development Establishment of Russian Academy of Medical Sciences»

V A Revyakina

Federal State Institute «Research and Development Establishment of Russian Academy of Medical Sciences»

O O Kirillova

Federal State Institute «Research and Development Establishment of Russian Academy of Medical Sciences»

I V Vorozhko

Federal State Institute «Research and Development Establishment of Russian Academy of Medical Sciences»

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