Expired air nitric oxide in patients with bronchial asthma and chronic obstructive pulmonary disease with different disease course

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Abstract


Expired air nitric oxide was measured in 113 subjects (26 healthy controls, 64 bronchial asthma (BA) patients and 23 COPD patients. In BA patients 10 had mild course of the disease. In 50 the course was estimated as moderate, 4 patients had severe course of the disease. In 20 patients BA was associated with COPD. The results revealed the dependence of FeNO on following factors: severity of the disease: in severe and moderate BA course FeNO was significantly higher than in mild BA; on phase of the disease: in exacerbation FeNO was significantly higher than in remission; on control of the disease: in patients, in whom it was difficult to reach the disease control, FeNO was higher than in others. In COPD patients FeNO was significantly lower than in BA ones. Even in subjects with marked airways inflammation manifested by high sputum cellularity FeNO was low.

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G B Fedoseev

Saint Petersburg Pavlov State Medical University

Email: fedoseevsp@mail.ru

V I Trofimov

Saint Petersburg Pavlov State Medical University

V G Timchik

Saint Petersburg Pavlov State Medical University

K V Negrutsa

Saint Petersburg Pavlov State Medical University

T S Razumovskaya

Saint Petersburg Pavlov State Medical University

N N Rogachova

Saint Petersburg Pavlov State Medical University

V A Alexandrin

Saint Petersburg Pavlov State Medical University

K N Kriakunov

Saint Petersburg Pavlov State Medical University

  1. Arnold W.P., Mittal C.K., Katsuki S., Murad F. Nitric oxide activates guanylate cyclase and increases guanosine 3D:5D-cyclic monophosphate levels tissue preparations. Proc. Natl. Acad. Sci USA. 1977, v. 74, p. 3203-3207.
  2. Fuchgott R.F., Zavadzki J.B. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, v. 288, p. 373-376.
  3. Palmer R.M.J., Ferringe A.G., Moncada S. Nitric oxide release accounts for the biological activity in endothelium-derived relaxing factor. Nature. 1987, v. 327, p. 524-526.
  4. Gustafsson L.E., Leone A.M., Persson M.G. at al. Endogenous nitric oxide is present in exhaled air of rabbits, guinea-pigs and humans. Biochem. Biophys. Res. Commun. 1991, v. 181, p. 852-857.
  5. Dillon W.C., Hampl V., Shultz P.J. et al. Origins ofbreath nitric oxide I humans. Chest. 1996, v. 1, p. 930-938.
  6. Landberg J.O., Weitzberg E., Landberg J.M., Alving K. Nitric oxide in exhaled air. Eur. Resp. J. 1996, v 1, p. 2671-2680.
  7. Соодаева С.К. Свободнорадикальные механизмы повреждения при болезнях органов дыхания. Пульмонология. 2012, № 1,с. 5-10.
  8. Geb N.M., Dweik R.A. Exhaled nitric oxide in asthma. From diagnosis, to monitoring, to screening: are we there yer? Chest. 2008, v. 133, p. 837-839.
  9. Langley J., Goldthorpe S., Craven M. et al. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. Journal of Allery and Clinical Immunology. 2003, v. 112, 2, p. 362-368.
  10. Cibella F., Cuttitta G., La Grutta S. еt al. Factors that influence exhaled nitric oxide in Italian schoolchildren. Annals of Allergy, Asthma and Immunology. 2008, v. 101, 4, p. 407-412.
  11. Spanier J., Hornung R.W., Kahn R.S. еt al. Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma, Pediatric Pulmonology. 2008, v. 43, 6, p.576-583.
  12. Renzetti G., Silvestre G., D'Amario C. et al. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children., Pediatrics. 2009, v. 123, 3, p. 1051-1058.
  13. Risconi F., Catelan D., Accetta G. et al. Asthma symptoms, lung function, and markers oxidative stress and inflammation in children exposed to oil refinery pollution. J. of Asthma. 2011, v. 48, 1, p. 84-90.
  14. Flamant-Hilin M., Caillaud D., Sacco P. et al. Air pollution and increased levels of factional exhaled nitric oxide in children with no history of airway damage. Journal of Toxicology and Environmental Health. 2010, v. 73, No. 4, p. 272-283.
  15. Berhane K., Zhang Y., Linn W.S. et al. The effect of ambient air pollution on exhaled nitric oxide in the children’s health study. Eur. Respir. Journal. 2011, v. 37, No. 5, p. 1029-1036.
  16. Wildhaber J.H., Hall G.L., Stick S.M. Measurements of exhaled nitric oxide with the singl thread technique and positive expiship and reratory pressure in infants. Am. J. Resir. Crit. Care Med. 1999, v. 159, p. 74-78.
  17. Barnes P.J. NO no NO in asthma? Thorax. 1996, v. 51, p. 218-220.
  18. Silkoff P.E., McClean P., Spino M. et al. Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest. 2001, v. 119, p. 1322-1328.
  19. Dweik R.A., Comhair S.A., Gaston B. et al. NO chemical events in human airway during the immediate and late antigen-induced asthmatic response. Proc. Natl. Acad. Sci. USA. 2001, v. 98, p. 2622-2627.
  20. Nathan C., Xie Q.W. Nitric oxide syntheses: roles, tolls and controls. Cell. 1994, v. 78, p. 915-918.
  21. Kiss J.P. Role of nitric oxide in the regulation monoaminergic neurotransmission. Brain Res. Bull. 2000, v. 52, p. 459-466.
  22. Lilly C.M., Stamler J.S., Gaston B. Modulation ofvasoactive intestinal peptide relaxation by NO in tracheally superfused guinea pig lung. Am. J. Physiol. 1993, v. 65, p. L410-L415.
  23. Ward J.K., Barnes P.J., Springall D.R. Distribution of human i-NANC bronchodilator and nitric oxideimmunoreactive nerves. Am. J. Resp. Cell Mol. boil. 1995, v. 13, p. 175-184.
  24. Fuchgott R.F., Vanhoutte P.M. Endothelium-derived relaxing and contracting factors. FASEB J. 1989, v. 3, p. 2007-2018.
  25. Fang F.C. Perspectives series: host/pathogen interactions. Mechanisms of nitric-related antimicrobial activity. J. Clin. Invest. 1997, v. 99, p. 2818-2825.
  26. Torre D., Pugliest A., Speranza F. Role of nitric oxide in HIV-1 infection: friend or foe? Lancet Infect. Dis. 2003, v. 3, p. 128-129.
  27. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide and petroxynitrite: the good, the bed and ugly. Am. J. Physiol. 1996, v. 271, p. 1424-1437.
  28. Barnes P.J., Dweik R.A., Gelb A.F. A comprehensive review: exhaled nitric oxide in pulmonary diseases. Chest. 2010, v. 138, p. 682-692.
  29. Лев Н.С. Патогенетическая роль NO при бронхиальной астме. Рос. вестн. перинатал. и педиатр. 2000, № 4, с. 48-51.
  30. Bhowmik A., Seemungal T.A., Donaldson G.C. et al. Effects of exacerbations and seasonality on exhaled nitric oxide in COPD. Eur. Respir. J. 2005, v. 26, p. 1009-1015.
  31. Kharitonov S.A., Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers. 2002, v. 7 (1), p. 1-32.
  32. Соодаева С.К. Свободнорадикальные механизмы повреждения при болезнях органов дыхания. Пульмонология. 2012, № 1, с. 5-10.
  33. Cookson W. Polygenes, asthma, and atopy. In: From Genetics to quality of life: XV World congress of asthmology. Seattle. 1996, p.15-19.
  34. Guo F.N., Comhair S.A., Zheng S. et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidеnce for transcriptional and posttranslational regulation of NO synthesis. J. Immunol. 2000, v. 164, p. 5970-5980.
  35. Hensel T.T., Kharitonov S.A., Donnelly L.E. et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and аsthmatics. FASEB J. 2003, v. 17, p. 1298-1300.
  36. Fabbri L.M., Romagnoli M., Corbetta L. et al. Differences in airway inflammation in patients with fixed airflowobstruction due to asthma or chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003, v. 167, p. 418-424.
  37. Brightling C.E., Symon F.A., Birring S.S. et al. Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax. 2003, v. 58, p. 528-532.
  38. Barreto M., Villf M.P., Monti F. et al. Additive effect of eosinophilia and atopy on exhaled nitric oxide levels in children with or without a history of respiratory symptoms. Pediatr. Allergy Immunol. 2005, v. 16, p. 52-58.
  39. Warke T.J., Fitch P.S., Brown V. et al. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Thorax. 2002, v. 57, p. 383-387.
  40. Payne D.N., Adcock I.M., Wilson N.M. et al. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am. J. Respir. Crit. Care Med. 2001, v. 164, p. 1376-1381.
  41. Dweik R.A., Boggs P.B., Erzurum S.C. et al. An official ATS clinical guideline: interretation of exhaled nitric oxide levels (Feno) for clinical applications. Am. J. Respir. Crit. Care Med. 2011, v. 184 (5), p. 602-615.
  42. Ihre E., Gustafsson L.E. et al. Ealy rise in exhaled no and mast cell activation in repeated low dose allergen challenge. Eur. Respir. J. 2006, v. 27, p. 1152-1159.
  43. Bastain TM., Islam T, Berhane K.T. et al. Exhaled nitric oxide, susceptibility and newonset asthma in the Children’s Health Study. Eur. Respir. J. 2011, v. 37 (3), p. 523-531.
  44. Frey U., Kuehni C., Roiha H. et al. Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in ifants. Am. J. Respir. Crit. Care Med. 2004, v. 170, p. 260-265.
  45. Verini M., Consilivio N.M., Di Pillo S. et al. FeNO as marker of airways inflammation: the possible implications in asthma management. J. of Allergy. 2010, v. 2010, Article 1D 691425, 7 p.
  46. Dupon L.J., Demedts M.G., Verleden G.M. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest. 2003, v. 123, p. 7516.
  47. Smith A.D., Cowan J.O., Filsell S. et al. Diagnosing asthma. Comparisons between exhaled nitric oxide measurements and conventional tests. Am. J. Respir. Crit. Care Med. 2004, v. 169, p. 4738.
  48. Deykin A., Massaeo A.F., Drazen J.M. et al. Exhaled nitric oxide as diagnostic test for asthma. Am. J. Respir. Crit. Care Med. 2003, v. 165, 1597601.
  49. Garcia-Rio F., Casitas R., Romero D. Utility of two-compartment models of exhaled nitric oxide in patients with asthma. J. Asthma. 2011, v 48 (4), p. 329-334.
  50. Ueno T, Kataora M., Hirano A. et al. Inflammatori makers in exhaled breath condensate from patients with asthma. Respirology. 2008, v. 13, p. 654-663.
  51. Cherot-Kornobis N., Hulo S., Edme J.L. et al. Analysis of nitrogen oxides (NO) I the exhaled breath condensate (EBC) of subjects with asthma as a complement to exhaled nitric oxide (FeNO) measurements: a cross sectional study. BMC Res. Notes. 2011, v. 4, p. 202.
  52. Pijnendurg M.W., Bakker E.M., Hop W.C. et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 2005, v. 172 (7), p. 831-836.
  53. Chatkin J.M., Ansarin K., Sikoff P.E. et al. Exhaled nitric oxide as a noninvasive assessment of chronic cough. Am. J. Respir. Crit. Care Med. 1999, v. 159, p. 18103.
  54. Perer-de-Luano L.A., Carballada F., Castro A.O. et al. Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma. Eur. Respir. J. 2010, v. 35, p. 1221-1227.
  55. Silkoff P.E., Carlson M., Bourke T et al. The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drag Administration for monitoring therapy in asthma. J. Allergy Clin. Immunol. 2004, v 114 (5), p. 1241-1256.
  56. Pijnenburg M.W, De Jongstae J.C. Exhaled nitric oxide in childhood asthma: a review. Clin. Exp. Allergy. 2008, v. 38, p. 246-259.
  57. Taylor D.R., Pijnenburg M.W, Smith A.D. et al. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax. 2006, v. 61 (9), p. 817-827.
  58. Kwok M.Y, Walsh-Kelly C.M., Gorelick M.H. The role of exhaled nitric oxide in evaluation o acute asthma in a pediatric emergency department. Acad. Emerg. Med. 2009, v. 16 (1), p. 21-28.
  59. Petsky H.L., Cates C.J., Lasserson TJ. et al. A systematic review and metaanalysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils. Thorax. 2012, v. 67 (3), p. 199-208.
  60. Borril Z., Clough D., Truman N. et al. Comparison on exhaled nitric oxide measurements performed using different analyses. Respir. Med. 2006, v. 100, p. 1392-1396.
  61. Khatri S.B., Hammel J., Kavuru M.S. et al. Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge. J. Appl. Physiol. 2003, v. 95, p. 436-440.
  62. Bodini A., Peroni D., Loiacono A. et al. Exhaled nitric oxide daily evaluation is effective in monitoring exposure to relevant allergens in asthmatic children. Chest 2007; 132: 1520-1525.
  63. Dweik R.A., Sokness R.L., Wenzel S. Us of exhaled nitric oxide measurement to identify a reactive at-risk phenotype among patients with asthma. Am. J. Respir. Crit. Care Med. 2010, v. 181, p. 1033-1041.
  64. Kharitonov S.A., Gonio М., Kelly C. et al. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur. Respir. J. 2003, v. 21, p. 433-438.
  65. Федосеев Г.Б., Трофимов В.И., Рогачева Н.Н., Разумовская Т.С. Роль нейтрофилов и бактериальной инфекции респираторного тракта у больных бронхиальной астмой и хронической обструктивной болезнью легких. Рос. Аллерголог. Журн. 2011, № 2,с. 34-43.

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