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In this article the problems of improving the control of bronchial asthma through optimization of bronchodilator therapy are discussed. Cholinergic mechanisms in the pathogenesis of asthma and the possibilities of use of long-acting m-anticholinergic - tiotropium (via liquid inhaler R espimat) - in the treatment of this disease are shown. Pharmacological properties of bronchodilators are discussed to identify the main groups of patients who need tiotropium therapy.

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About the authors

O M Kurbacheva

Institute of Immunology

Moscow, Russia

S A Polner

Institute of Immunology

Moscow, Russia

D S Smirnov

Institute of Immunology

Moscow, Russia


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