PROPERTIES OF POLLEN ALLERGENS AND THEIR CLINICAL SIGNIFICANCE



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Abstract

Pollen, the male gametophyte of flowering plant species, is one of the most predominant sources of environmental allergens, and a significant cause of allergic disease. This review discusses the nature of pollen proteins as allergens, their effect on the human immune system. The influence of cross-reactive pollen allergens to the incidence of food sensitivities is also discussed. Flowering plant species that posses allergenic pollen, identified with allergens cloned from these species, are also discussed.

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About the authors

B A Shamgunova

Astrakhan State Medical Academy

Russia

B N Levitan

Astrakhan State Medical Academy

Email: bolev@mail.ru
Russia

A R Sartova

Astrakhan State Medical Academy

Russia

L G Yarilina

Institute of Professional Development of Federal Medical Biological Agency

Moscow, Russia

S V Suchkov

Moscow State University of Medicine and Dentistry; First Moscow State Medical University; European Association for Predictive, Preventive and Personalized Medicine

Russia; Brussels, EU

References

  1. Puc M. Characterization of pollen allergens. Ann. Agric. Environ. Med. 2003, v. 10, p. 143-149.
  2. D’Amato G., Cecchi L., Bonini S. et al. Allergenic pollen and pollen allergy in Europe. Allergy. 2007, v. 62, p. 976-990.
  3. Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «Гэотар-Медиа». 2009, 656 с.
  4. Клиническая аллергология и иммунология. Под ред. Л.А Горячкиной, К.П. Кашкина. М., «Миклош». 2009, 432 с.
  5. Фрадкин В.А. Диагностические и лечебные аллергены. М., «Медицина». 1990, 256 с.
  6. Гущин И.С., Курбачева О.М. Аллергия и аллергенспецифическая иммунотерапия. М., «Фармарус Принт Медиа». 2010, 228 с.
  7. Tinghino R., Twardosz A., Barletta B. et al. Molecular, structural, and immunologic relationship between different families of recombinant calcium-binding pollen allergen. J. Allergy Clin. Immunol. 2002, v. 109, p. 314-320.
  8. Клиническая аллергология. Руководство для практических врачей. Под ред. Р.М. Хаитова. М., «МЕДпресс-информ». 2002, 624 с.
  9. DeWeerd N., Bhalla P.L., Singh N.B. Aeroallergens and polli- nosis: molecular and immunological characteristics of cloned pollen allergens. Aerobiologia. 2002, v. 18, p. 87-106.
  10. Райкис Б.Н., Пожарская В.О., Казиев А.Х. Перспективы разработки рекомбинантных аллергенов. Аллергология. 2002, № 2, с. 43-49.
  11. Marth K., Focke-Tejkl M., Lupinek C. et al. Allergen peptides, recombi-nant allergens and hypoallergens for allergen-specific immunotherapy. Curr. Treat. Options Allergy. 2014, v. 26, p. 91-106.
  12. Moverare R., Westritschnig K., Svensson M. et al. Different IgE reactivity profiles in birch pollen-sensitive patients from six European populations revealed by recombinant allergens: an imprint of local sensitization. Int. Arch. Allergy Immunol. 2002, v. 128, p. 325-335.
  13. Баранов А.А., Балаболкин И.И., Субботина О.А. Гастроинтестинальная пищевая аллергия у детей. М., «Династия». 2002, 172 с.
  14. Weber R.W. Cross reactivity of pollen allergens: impact on allergen immunotherapy. Ann. Allergy Asthma Immunol. 2007, v. 99, p. 203-211.
  15. Bohle B. The impact ofpollen-related food allergens on pollen allergy. Allergy. 2007, v. 62, p. 3-10.
  16. Hoffman A. Pollen food syndrome: update on allergens. Curr. Allergy Asthma Rep. 2008, v. 8, p. 413-417.
  17. Сергеев А.В., Мокроносова М.А. Аллергия к пищевым аллергенам растительного происхождения у больных поллинозом. Аллергология. 2002, № 1, с. 51-55.
  18. Andersson K., Lidholm J. Characteristics and immunobiology of grasspollen allergens. Int. Arch. Allergy Immunol. 2003, v. 130, p. 87-107.
  19. Gadermaier G., Dedic A., Obermeyer G. et al. Biology of weed pollen allergen. Curr. Allergy Asthma Rep. 2004, v. 4, p. 391-400.
  20. Verdino P, Barderas R., Villalba M. et al. Three-dimensional structure of cross-reactive pollen allergen Che a 3: visualizing cross-reactivity on molecular surfaces of weed, grass, and tree pollen allergens. J. Immunol. 2008, v. 180, p. 2313-2321.
  21. Bass E., Mokronosova M. Clinical relevance of IgE-antibodies to PR-10 proteins in patients with syndrome of oral allergy. Clin. and Translat. Allergy. 2013, v. 3, р. 90.
  22. Barderas R., Villalba M., Pascual C.Y. et al. Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties. J. Allergy Clin. Immunol. 2004, v. 113, p. 1192-1198.
  23. Tinghino R., Twardosz A., Barletta B. et al. Molecular, structural, and immunologic relationship between different families of recombinant calcium-binding pollen allergen. J. Allergy Clin. Immunol. 2002, v. 109, p. 314-320.
  24. Bacsi A., Choudhury B.K., Dharajiya N. et al. Subpollen particles: Carriers of allergenic proteins and oxidases. J. Allergy Clin. Immunol. 2006, v. 118, p. 844-850.
  25. Traidl-Hoffman C., Kasche A., Menzel A. et al. Impact of pollen on human health: more than allergen carriers? Int. Arch. Allergy Immunol. 2003, v. 131, p. 1-13.
  26. Traidl-Hoffman C., Kasche A., Jakob T et al. Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes. J. Allergy Clin. Immunol. 2002, v. 109, p. 831-838.
  27. Mothes N., Valenta R. Biology of Tree pollen allergen. Curr. Allergy Asthma Rep. 2004, v. 4, p. 384-390.
  28. Allergen nomenclature IUIS Allergen Nomenclature Sub-Committee http://www.allergen.org.
  29. Taketomi E.A., Sopelete M.K., Moreira P.F. et. al. Pollen allergic disease: pollens and its major allergens Rev. Bras. Otorrinolaringol. 2006, v. 72, p. 78-82.
  30. Mohapatra S.S., Lockey R.F., Shirley S. Immunobiology of grass pollen allergens. Curr. Allergy Asthma Rep. 2005, v. 5, p. 381-387.
  31. Barderas R., Villalba M., Lombardero M. et al. Identication and characterization of Che a 1 allergen from Chenopodium albumpollen. Int. Arch. Allergy Immunol. 2002, v. 127, p. 47-54.
  32. Barderas R., Vilalba M, Rodriguez R. Recombinant expression, purification and cross-reactivity of chenopod profilin: rChe a 2 as a good marker for profiling sensitization. Biol. Chem. 2004, v. 385, p. 731-737.
  33. Himly M., Jahn-Schmid B., Dedic A. et al. Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensinlike and a hydroxyproline - rich domain. Faseb J. 2003, v. 17, p. 106-108.
  34. Pastorello E.A. Pravettoni V., Farioli L. et al. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression. J. Allergy Clin. Immunol. 2002, v. 110, p. 310-317.
  35. Wopfner N., Gadermaier G., Egger M. et al. The spectrum of allergens in ragweed and mugwort pollen. Int. Arch. Allergy Immunol. 2005, v. 38, p. 337-346.
  36. Mayoral M., Calderon H., Cano R. et al. Allergic Rhino-conjunctivitis caused by Cannabis sativa pollen. J. Investig. Allergolog. Clin. Immunolog. 2008, v. 18, p. 71-77.
  37. Jutel M., Solarewicz-Madejek K., Smolinska S. Recombinant allergens: the present and the future. Hum. Vaccin. Immunother. 2012, v. 8, p. 1534-1543.
  38. Астафьева Н.Г, Горячкина Л.А. Аллерген-специфическая иммунотерапия в клинической практике. Учебное пособие. Саратов, «Изд-во СГМУ». 2007, 87 с.
  39. Гущин И.С., Данилычева И.В. Аллерген-специфические кожные пробы уколом (prik-tests) в работе врача-аллерголога. Рос. Аллергол. Журн. 2013, № 4, с. 44-53.

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