Epidermal barrier defect in atopic dermatitis children and its role in the development of allergic sensitization and respiratory allergy



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Abstract

Atopic dermatitis (AD) is the most common allergic disease in young children which is often (almost in half of cases) the beginning of so-called «allergic march», followed by the addition of respiratory allergy symptoms. In this review we present some studies to explain one of the possible mechanisms for the realization of allergic march associated with transepidermal sensitization in atopic dermatitis infants. Perhaps, the data may help in establishment of new strategies for allergy prevention in the near future.

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About the authors

N B Migacheva

Samara State Medical University

Email: nbmigacheva@gmail.com

A V Zhestkov

Samara State Medical University

T I Kaganova

Samara State Medical University

O G Elisutina

Institute of Immunology

G I Bibarsova

Samara State Medical University

O V Shtyrbul

Institute of Immunology

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