Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press43610.36691/RJA436ArticlesСтатьиResearch ArticleEpidermal barrier defect in atopic dermatitis children and its role in the development of allergic sensitization and respiratory allergyНарушение эпидермального барьера у детей с атопическим дерматитом и его роль в развитии аллергической сенсибилизации и респираторной аллергииMigachevaN BМигачеваНаталья Бегиевнаnbmigacheva@gmail.comZhestkovA VЖестковА ВKaganovaT IКагановаТ ИElisutinaO GЕлисютинаО ГBibarsovaG IБибарсоваГ ИShtyrbulO VШтырбулО ВSamara State Medical UniversityГБОУ БПО «Самарский государственный медицинский университет» Минздрава РоссииInstitute of ImmunologyФГБУ «ГНЦ Институт иммунологии» ФМБА России15102015125NO5 (2015)№5 (2015)394810032020Copyright ©; 2015, Pharmarus Print MediaCopyright ©; 2015, Фармарус Принт Медиа2015Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/436

Atopic dermatitis (AD) is the most common allergic disease in young children which is often (almost in half of cases) the beginning of so-called «allergic march», followed by the addition of respiratory allergy symptoms. In this review we present some studies to explain one of the possible mechanisms for the realization of allergic march associated with transepidermal sensitization in atopic dermatitis infants. Perhaps, the data may help in establishment of new strategies for allergy prevention in the near future.

Атопический дерматит (АтД) является самым частым аллергическим заболеванием у детей раннего возраста и почти в половине случаев становится началом развития т. н. «аллергического марша» с последующим присоединением симптомов респираторной аллергии. В настоящем обзоре мы представляем исследования, объясняющие один из возможных механизмов реализации аллергического марша, связанный с формированием чрескожной сенсибилизации у детей с атопическим дерматитом. Возможно, представленные данные помогут в создании новых стратегий для профилактики аллергии в ближайшем будущем.

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