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The correction of epidermal barrier dysfunction in atopic dermatitis patients
- Authors: Elisyutina OG1, Shtyrbul OV1, Zemskaya EN1
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Affiliations:
- Institute of Immunology
- Issue: Vol 13, No 3 (2016)
- Pages: 59-64
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/386
- DOI: https://doi.org/10.36691/RJA386
- ID: 386
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Abstract
Atopic dermatitis is chronic inflammatory multifactorial disease, which has genetic disorders, immune mechanisms of development and is under the ainfluence of a combination of exogenous and endogenous factors. Recently a leading role of the epidermal barrier dysfunction in the pathogenesis of atopic dermatitis was shown. The article presents data about emollient for skin care efficacy - Cetaphil® RESTORADERM, which consists of preceramides and filaggrin breakdown products in complex treatment of atopic dermatitis patients.
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About the authors
O G Elisyutina
Institute of Immunology
Email: el-olga@yandex.ru
Moscow, Russia
O V Shtyrbul
Institute of ImmunologyMoscow, Russia
E N Zemskaya
Institute of ImmunologyMoscow, Russia
References
- Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, 656 с.
- Elias P.M., Menon G.K. Structural and lipid biochemical correlates of the epidermial permeability barrier. In: Skin Lipids, Advances in Lipid Research. 1991, 26 p.
- Гущин И.С. Эпидермальный барьер и аллергия. Рос. Аллергол. Журн. 2007, № 2, с. 3-16.
- Cork M.J., Danby S.G., Vasilopoulos Y. et al. Epidermal barrier dysfunction in atopic dermatitis. Journal of Investigative Dermatology. 2009, v. 129, p. 1892-1908.
- Elias P.M., Eichenfield L.F., Fowler J.F. Jr. et al. Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications. Semin. Cutan. Med. Surg. 2013, v. 32, p. 21-24.
- Proksch E., Fölster-Holst R., Jensen J.M. Skin barrier function, epidermal proliferation and differentiation in eczema. J. Dermatol. Sci. 2006, v. 43, p. 159-169.
- Grimalt R., Menegaud V., Cambazard F. The steroid -sparing effect of an emollient therapy in infants with atopic dermatitis a randomized controlled study. Dermatology. 2007, v. 214, p. 61-67.
- Irvine A.D., McLean W.H., Leung D.Y. Filaggrin mutations associated with skin and allergic diseases. N. Engl. J. Med. 2011, v. 365, p. 1315-1327.
- Janssens M., van Smeden J., Gooris G.S. et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients J. Lipid. Res. 2012, v. 53, p. 2755-2766.
- Imokawa G., Abe A., Jin K. et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J. Invest. Dermatol. 1991, v. 96, p. 523-526.
- Di Nardo A., Wertz P., Giannetti A., Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm. Venereol. 1998, v. 78, p. 27-30.
- Ishikawa J., Narita H., Kondo N. et al. Changes in the ceramide profile of atopic dermatitis patients J. Invest. Dermatol. 2010, v. 130, p. 2511-2514.
- Хаитов Р.М., Ильина Н.И. Аллергология. Федеральные клинические рекомендации. М., «Фармарус Принт Медиа». 2014, 124 с.
- Руководство для врачей: Аллергология. Фармакотерапия без ошибок. Под ред. Р.М. Хаитова. М., «E-ното». 2013, 496 с.
- Simpson E., Dutronc Y. A New Body Moisturizer Increases Skin Hydration and Improves Atopic Dermatitis Symptoms Among Children and Adults. Journal of Drugs in Dermatology. 2011, v. 10, p. 744-749.
- Simpson E. Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J. Dermatol. Treat. 2013, v. 24, p. 122-125.
- Stadler J.F., Taieb A. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993, v. 186, p. 23-31.
- Ring J., Alomar A., Bieber T et al. Guidelines for treatment of atopic eczema (atopic dermatitis). Part I. J. Eur. Acad. Dermatol. Venereol. 2012, v. 26, p. 1045-1060.
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