Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media38610.36691/RJA386Research ArticleThe correction of epidermal barrier dysfunction in atopic dermatitis patientsElisyutinaO Gel-olga@yandex.ruShtyrbulO V-ZemskayaE N-Institute of Immunology15062016133596410032020Copyright © 2016, Pharmarus Print Media2016Atopic dermatitis is chronic inflammatory multifactorial disease, which has genetic disorders, immune mechanisms of development and is under the ainfluence of a combination of exogenous and endogenous factors. Recently a leading role of the epidermal barrier dysfunction in the pathogenesis of atopic dermatitis was shown. The article presents data about emollient for skin care efficacy - Cetaphil® RESTORADERM, which consists of preceramides and filaggrin breakdown products in complex treatment of atopic dermatitis patients.Cetaphil® RESTORADERM™atopic dermatitisepidermal barrierepidermis lipidsCetaphil® RESTORADERM™атопический дерматитэпидермальный барьерлипиды эпидермиса[Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, 656 с.][Elias P.M., Menon G.K. Structural and lipid biochemical correlates of the epidermial permeability barrier. In: Skin Lipids, Advances in Lipid Research. 1991, 26 p.][Гущин И.С. Эпидермальный барьер и аллергия. Рос. Аллергол. Журн. 2007, № 2, с. 3-16.][Cork M.J., Danby S.G., Vasilopoulos Y. et al. Epidermal barrier dysfunction in atopic dermatitis. Journal of Investigative Dermatology. 2009, v. 129, p. 1892-1908.][Elias P.M., Eichenfield L.F., Fowler J.F. Jr. et al. Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications. Semin. Cutan. Med. Surg. 2013, v. 32, p. 21-24.][Proksch E., Fölster-Holst R., Jensen J.M. Skin barrier function, epidermal proliferation and differentiation in eczema. J. Dermatol. Sci. 2006, v. 43, p. 159-169.][Grimalt R., Menegaud V., Cambazard F. The steroid -sparing effect of an emollient therapy in infants with atopic dermatitis a randomized controlled study. Dermatology. 2007, v. 214, p. 61-67.][Irvine A.D., McLean W.H., Leung D.Y. Filaggrin mutations associated with skin and allergic diseases. N. Engl. J. Med. 2011, v. 365, p. 1315-1327.][Janssens M., van Smeden J., Gooris G.S. et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients J. Lipid. Res. 2012, v. 53, p. 2755-2766.][Imokawa G., Abe A., Jin K. et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J. Invest. Dermatol. 1991, v. 96, p. 523-526.][Di Nardo A., Wertz P., Giannetti A., Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm. Venereol. 1998, v. 78, p. 27-30.][Ishikawa J., Narita H., Kondo N. et al. Changes in the ceramide profile of atopic dermatitis patients J. Invest. Dermatol. 2010, v. 130, p. 2511-2514.][Хаитов Р.М., Ильина Н.И. Аллергология. Федеральные клинические рекомендации. М., «Фармарус Принт Медиа». 2014, 124 с.][Руководство для врачей: Аллергология. Фармакотерапия без ошибок. Под ред. Р.М. Хаитова. М., «E-ното». 2013, 496 с.][Simpson E., Dutronc Y. A New Body Moisturizer Increases Skin Hydration and Improves Atopic Dermatitis Symptoms Among Children and Adults. Journal of Drugs in Dermatology. 2011, v. 10, p. 744-749.][Simpson E. Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J. Dermatol. Treat. 2013, v. 24, p. 122-125.][Stadler J.F., Taieb A. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993, v. 186, p. 23-31.][Ring J., Alomar A., Bieber T et al. Guidelines for treatment of atopic eczema (atopic dermatitis). Part I. J. Eur. Acad. Dermatol. Venereol. 2012, v. 26, p. 1045-1060.]