Modern possibilities of allergy diagnostics in real clinical practice

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

More than 20% of people worldwide suffer from allergic diseases. The high prevalence and wide range of provocative factors, which are increasing daily, complicate the diagnostic search. On the one hand, this leads to inadequately extensive dietary and lifestyle restrictions that reduce the quality of life for patients; on the other hand, it results in the failure to identify life-threatening allergens. The discovery of immunoglobulin E over 60 years ago initiated the search for specific biomarkers to etermine the causes of allergic diseases. Traditional methods of allergen diagnostics have several limitations that hinder the search for potential allergic disease triggers.

The article discusses modern laboratory approaches to multicomponent molecular allergen diagnostics, describes its differences from traditional diagnostic methods, and analyzes the advantages, prospects, limitations, and shortcomings of this method. It also presents a comparative characterization of the test systems available today.

The article presents four clinical cases that demonstrate the capabilities of the multicomponent ALEX 2 test system in diagnostics, choice of therapy tactics, and in forming further personalized recommendations for patients suffering from various allergic diseases.

Full Text

Restricted Access

About the authors

Gennady A. Novik

Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: ga_novik@mail.ru
ORCID iD: 0000-0002-7571-5460
SPIN-code: 6289-0209

MD, Dr. Sci. (Med), Professor

Россия, Saint Petersburg

Olga B. Tamrazova

Peoples' Friendship University of Russia

Email: anait_tamrazova@mail.ru
ORCID iD: 0000-0003-3261-6718
SPIN-code: 5476-8497

MD, Dr. Sci. (Med), Professor

Россия, Moscow

Marina V. Zhdanova

Saint Petersburg State Pediatric Medical University

Email: zhdanova-marina@rambler.ru
ORCID iD: 0000-0001-7035-0100
SPIN-code: 2204-3465

MD, Cand. Sci. (Med.), Assistant Professor

Saint Petersburg

Anait V. Tamrazova

Central State Medical Academy of Department of Presidential Affairs

Email: anaittamrazova@gmail.com
ORCID iD: 0000-0002-4672-697X
SPIN-code: 1563-1190

MD

 

 
Россия, Moscow

Olga I. Filimonova

International pharmaceutical company "Innovatsionnye immunnye tekhnologii"

Email: ofilimonova.iit@gmail.com
ORCID iD: 0000-0001-9660-464X
SPIN-code: 7127-9906
Россия, Moscow

References

  1. Alsaleh NB, Brown JM. Engineered nanomaterials and type I allergic hypersensitivity reactions. Front Immunol. 2020;(11):222. EDN: KRHHHV doi: 10.3389/fimmu.2020.00222
  2. Sánchez-Borges M, Martin BL, Muraro AM, et al. The importance of allergic disease in public health: An iCAALL statement. World Allergy Organ J. 2018;11(1):8. doi: 10.1186/s40413-018-0187-2
  3. Gupta RS, Warren CM, Smith BM, et al. Prevalence and severity of food allergies among US adults. JAMA Netw Open. 2019;2(1):e185630. doi: 10.1001/jamanetworkopen.2018.5630
  4. Dribin TE, Motosue MS, Campbell RL. Overview of allergy and anaphylaxis. Emerg Med Clin North Am. 2022;40(1):1–17. EDN: TVSRDO doi: 10.1016/j.emc.2021.08.007
  5. Turner PJ, Campbell DE, Motosue MS, Campbell RL. Global trends in anaphylaxis epidemiology and clinical implications. J Allergy Clin Immunol Pract. 2020;8(4):1169–1176. doi: 10.1016/j.jaip.2019.11.027
  6. Mullins RJ, Wainstein BK, Barnes EH, et al. Increases in anaphylaxis fatalities in Australia from 1997 to 2013. Clin Exp Allergy. 2016;46(8):1099–1110. doi: 10.1111/cea.12748
  7. Ma L, Danoff TM, Borish L. Case fatality and population mortality associated with anaphylaxis in the United States. J Allergy Clin Immunol. 2014;133(4):1075–1083. doi: 10.1016/j.jaci.2013.10.029
  8. Matsui EC, Sampson HA, Bahnson HT, et al. Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma. Allergy. 2010;65(11):1414–1422. doi: 10.1111/j.1398-9995.2010.02412.x
  9. Lis K, Bartuzi Z. Selected technical aspects of molecular allergy diagnostics. Curr Issues Mol Biol. 2023;45(7):5481–5493. EDN: BSGJCH doi: 10.3390/cimb45070347
  10. Steering Committee Authors; Review Panel Members. A WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnosis (PAMD): Update 2020. World Allergy Organ J. 2020;13(2):100091. doi: 10.1016/j.waojou.2019.100091
  11. Luengo O, Labrador-Horrillo M. Molecular allergy diagnosis in clinical practice: Frequently asked questions. J Investig Allergol Clin Immunol. 2022;32(1):1–12. EDN: FOANVW doi: 10.18176/jiaci.0769
  12. Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020;13(2):100080. EDN: UCHPGJ doi: 10.1016/j.waojou.2019.100080
  13. Dodig S, Čepelak I. The potential of component-resolved diagnosis in laboratory diagnostics of allergy. Biochem Med (Zagreb). 2018;28(2):020501. doi: 10.11613/BM.2018.020501
  14. Dodig S, Čepelak I. The potential of component-resolved diagnosis in laboratory diagnostics of allergy. Biochem Med (Zagreb). 2018;28(2):020702. doi: 10.11613/BM.2018.021201
  15. Alessandri C, Ferrara R, Bernardi ML, et al. Diagnosing allergic sensitizations in the third millennium: Why clinicians should know allergen molecule structures. Clin Transl Allergy. 2017;(7):21. doi: 10.1186/s13601-017-0158-7
  16. Röseler S, Balakirski G, Plange J, et al. [Anaphylaxie auf PR-10-Proteine (Bet v1-Homologe). (In German).] Hautarzt. 2013;64(12):890–892. doi: 10.1007/s00105-013-2683-1
  17. Smolnikov EV, Litovkina AO, Byazrova MG. Development of cofactor-dependent anaphylaxis in a patient with cross-reactive food. Russ J Allergol. 2023;20(4):543–548. EDN: LBTHQL doi: 10.36691/RJA16898
  18. Kleine-Tebbe J, Jakob T. Molecular allergy diagnostics using IgE singleplex determinations: Methodological and practical considerations for use in clinical routine: Part 18 of the series molecular allergology. Allergo J Int. 2015;(24):185–197. doi: 10.1007/s40629-015-0067-z
  19. Westwood M, Ramaekers B, Lang S, et al. ImmunoCAP ISAC and microtest for multiplex allergen testing in people with difficult to manage allergic disease: A systematic review and cost analysis. Health Technol Assess. 2016;20(67):1–178. doi: 10.3310/hta20670
  20. Platteel AC, van der Pol P, Murk JL, et al. A comprehensive comparison between ISAC and ALEX2 multiplex test systems. Clin Chem Lab Med. 2022;60(7):1046–1052. doi: 10.1515/cclm-2022-0191
  21. Glatz M, Bosshard PP, Hoetzenecker W, Schmid-Grendelmeier P. The role of Malassezia spp. in atopic dermatitis. J Clin Med. 2015;4(6):1217–1228. doi: 10.3390/jcm4061217
  22. Nowicka D, Nawrot U. Contribution of Malassezia spp. to the development of atopic dermatitis. Mycoses. 2019;62(7):588–596. doi: 10.1111/myc.12913
  23. Schmid-Grendelmeier P, Flückiger S, Disch R, et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol. 2005;115(5):1068–1075. doi: 10.1016/j.jaci.2005.01.065
  24. Huang Y, Wang C, Lin X, et al. Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients. Clin Transl Allergy. 2019;(9):64. doi: 10.1186/s13601-019-0305-4
  25. Gargano D, Appanna R, Santonicola A, et al. Food allergy and intolerance: A narrative review on nutritional concerns. Nutrients. 2021;13(5):1638. doi: 10.3390/nu13051638
  26. Eigenmann PA, Caubet JC, Zamora SA. Continuing food-avoidance diets after negative food challenges. Pediatr Allergy Immunol. 2006;17(8):601–605. doi: 10.1111/j.1399-3038.2006.00455.x
  27. Miceli Sopo S, Monaco S, Greco M, Onesimo R. Prevalence of adverse reactions following a passed oral food challenge and factors affecting successful re-introduction of foods. A retrospective study of a cohort of 199 children. Allergol Immunopathol (Madr). 2016;44(1):54–58. doi: 10.1016/j.aller.2015.04.010
  28. Greenhawt M, Oppenheimer J, Nelson M, et al. Sublingual immunotherapy: A focused allergen immunotherapy practice parameter update. Ann Allergy Asthma Immunol. 2017;118(3):276–282.e2. doi: 10.1016/j.anai.2016.12.009

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Symptom of a "dirty neck": reticular pigmentation, poikiloderma, dyschromia, characteristic of head-and-neck atopic dermatitis.

Download (88KB)
Indexing metadata

Copyright © Pharmarus Print Media, 2024



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies