Modern possibilities of allergy diagnostics in real clinical practice

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Abstract

More than 20% of people worldwide suffer from allergic diseases. The high prevalence and wide range of provocative factors, which are increasing daily, complicate the diagnostic search. On the one hand, this leads to inadequately extensive dietary and lifestyle restrictions that reduce the quality of life for patients; on the other hand, it results in the failure to identify life-threatening allergens. The discovery of immunoglobulin E over 60 years ago initiated the search for specific biomarkers to etermine the causes of allergic diseases. Traditional methods of allergen diagnostics have several limitations that hinder the search for potential allergic disease triggers.

The article discusses modern laboratory approaches to multicomponent molecular allergen diagnostics, describes its differences from traditional diagnostic methods, and analyzes the advantages, prospects, limitations, and shortcomings of this method. It also presents a comparative characterization of the test systems available today.

The article presents four clinical cases that demonstrate the capabilities of the multicomponent ALEX 2 test system in diagnostics, choice of therapy tactics, and in forming further personalized recommendations for patients suffering from various allergic diseases.

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About the authors

Gennady A. Novik

Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: ga_novik@mail.ru
ORCID iD: 0000-0002-7571-5460
SPIN-code: 6289-0209

MD, Dr. Sci. (Med), Professor

Russian Federation, Saint Petersburg

Olga B. Tamrazova

Peoples' Friendship University of Russia

Email: anait_tamrazova@mail.ru
ORCID iD: 0000-0003-3261-6718
SPIN-code: 5476-8497

MD, Dr. Sci. (Med), Professor

Russian Federation, Moscow

Marina V. Zhdanova

Saint Petersburg State Pediatric Medical University

Email: zhdanova-marina@rambler.ru
ORCID iD: 0000-0001-7035-0100
SPIN-code: 2204-3465

MD, Cand. Sci. (Med.), Assistant Professor

Saint Petersburg

Anait V. Tamrazova

Central State Medical Academy of Department of Presidential Affairs

Email: anaittamrazova@gmail.com
ORCID iD: 0000-0002-4672-697X
SPIN-code: 1563-1190

MD

 

 
Russian Federation, Moscow

Olga I. Filimonova

International pharmaceutical company "Innovatsionnye immunnye tekhnologii"

Email: ofilimonova.iit@gmail.com
ORCID iD: 0000-0001-9660-464X
SPIN-code: 7127-9906
Russian Federation, Moscow

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2. Fig. 1. Symptom of a "dirty neck": reticular pigmentation, poikiloderma, dyschromia, characteristic of head-and-neck atopic dermatitis.

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