What is аsthma-COPD Overlap syndrome (ACOS), diagnostics and treatment



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Abstract

175 patients were examined: 78 patients with bronchial asthma (BA), 39 with Asthma-COPD Overlap Syndrome (ACOS), 38 with chronic obstructive pulmonary disease (COPD) and 20 healthy individuals. A general clinical and laboratory examination was conducted, α1-antitrypsin (AAT), IgG and IgA to four bacterial antigens were determined, and pulmonary function test was studied. The clinical and spirometry data (characterizing the ACOS) were received. Negative association of AAT with respiratory function parameters in patients with ACOS, high levels of IgG antibodies to bacterial antigens and the lack of these connections in patients with BA and COPD allows us to consider ACOS to be independent nosological form related with microbial inflammation and marked by the AAT.

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About the authors

G B Fedoseev

Pavlov First Saint Petersburg State Medical University

Email: fedoseevsp@mail.ru

V I Trofimov

Pavlov First Saint Petersburg State Medical University

K V Negrutsa

Pavlov First Saint Petersburg State Medical University

V G Timchik

Pavlov First Saint Petersburg State Medical University

V I Golubeva

Pavlov First Saint Petersburg State Medical University

V A Aleksandrin

Pavlov First Saint Petersburg State Medical University

T S Razumovskaya

Pavlov First Saint Petersburg State Medical University

U D Rabik

Pavlov First Saint Petersburg State Medical University

K N Kryakunov

Pavlov First Saint Petersburg State Medical University

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