TSLP (LIMFOPOETIN IZ STROMY TIMUSA) -NOVYY PATOGENETIChESKIY FAKTOR ALLERGII



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Abstract

Эпителиальные клетки тимуса и барьерных тканей секретируют цитокин, родственный интерлейки8
ну87 (IL87) - TSLP (Thymic stromal limphopoietin). Действуя на свою главную мишень - дендритные
клетки, он индуцирует экспрессию мембранной молекулы OX40L. В процессе презентации антигена/
аллергена Т8лимфоциту через эту молекулу передается костимулирующий сигнал в CD4+ Т8клетку.
Этот сигнал при условии отсутствия IL812 вызывает дифференцировку воспалительных Th28клеток,
которые отличаются от обычных (регулирующих) Th28клеток тем, что наряду с типичными Th28ци8
токинами они вырабатывают фактор некроза опухоли, но не IL810. Результатом является индукция
аллергического воспаления. Показана роль TSLP в развитии атопического дерматита и бронхиальной
астмы. Формирование аллергических процессов можно предотвратить или ослабить, используя моно8
клональные антитела к OX40L, что предполагается использовать в качестве нового подхода к терапии
аллергических заболеваний.

About the authors

A A Yarilin

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