DIAGNOSTIChESKAYa ZNAChIMOST' KOZhNYKhPROB I OPREDELENIYa aLLERGEN-SPETsIFIChESKOGO IgE PRI RESPIRATORNOYI PIShchEVOY ALLERGII



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Abstract

Хотя общеизвестно, что у лиц с сенсибилизацией к экзоаллергенам обнаруживается высокое содержа-
ние аллерген-специфического IgE, связь между количеством этих антител, результатами кожного тес-
тирования, провокационных проб с аллергенами и клиническими проявлениями заболевания остается
недостаточно ясной. Настоящий обзор суммирует сравнительные данные о преимуществах и недостат-
ках аллерген-специфического тестирования in vivo по отношению к методам in vitro для диагностики
аллергического заболевания. Врачу следует помнить, что положительные результаты определения
аллерген-специфического IgE не равнозначны установлению диагноза аллергии; эти результаты лишь
свидетельствуют о присутствии молекулы с определенной иммунологической специфической функци-
ей. Наилучшим стандартом диагностики аллергического заболевания остается сочетание клинической
оценки, результатов кожных и провокационных проб, двойного слепого провокационного тестирования,
определения аллерген-специфического IgE и клинической демонстрации связи симптомов заболевания
с IgE-опосредованным механизмом.

About the authors

V G Chitaeva

I S Gushchin

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