The level of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic and infectious rhinitis

  • Authors: Mokronosova MA1, Kochetova Y.I1, Smol'nikova EV1, Protasov PG1, Mokronosova MA1, Kochetova J.L1, Smolnikova EV1, Protasov PG1
  • Affiliations:
  • Issue: Vol 4, No 3 (2007)
  • Pages: 20-24
  • Section: Articles
  • URL:
  • Cite item
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access


Background. Allergic rhinitis manifestates as the local inflammation with minimum pathophysiological disorders.
Revealing of local inflammatory markers in nasal secret is actual problem.
The aim: to detect the levels of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in
patients with allergic rhinitis and infectious rhinitis.
Materials and methods. 60 patients with allergic rhinitis and 30 patients with infectious rhinitis were observed.
The diagnosis and severity of disease were rated in conformity with international standards.
Results. Mean level of free hemoglobin in patients with allergic rhinitis was significantly higher in comparison
with the group of infectious rhinitis and had compiled 55,9 mkg/ml and 6,1 mkg/ml. The quantity of eosinophils
more than 10% was observed in 43,9% of cases in patients with allergic rhinitis and in 11,1% in patients with
infectious rhinitis. Frequency of elevated level of eosinophilic cationic protein in patients with allergic rhinitis
has made 87,9%, in comparison with infectious rhinitis where it corresponded to 28%. The highest sensitivity
(87,9%) was found in method of definition of eosinophilic cationic protein. Method of free hemoglobin's
definition was characterized by high parameter of correct diagnosis's probability - 97,3%.
Conclusion. Methods of definition of eosinophilic cationic protein and free hemoglobin in nasal secret had
possessed with the highest diagnostic efficiency.

M A Mokronosova

Yu I Kochetova

E V Smol'nikova

P G Protasov

M A Mokronosova

Ju L Kochetova

E V Smolnikova

P G Protasov

  1. Гущин И.С., Ильина Н.И., Польнер С.А. Аллергический ринит. Пособие для врачей. М., 2002, 72 с.
  2. Cauwenberg P. , Bachert C., Passalacqua G. Consensus statement on the treatment of allergic rhinitis. Allergy, 2000, v. 55 (2), p. 116-134.
  3. Пыцкий В.И., Адрианова Н.В., Артомасова А.В. Аллергические заболевания. М.,1999, 470 с.
  4. Wilson S.J., Lau L., Howarth P.H. Inflammatory mediators in naturally occurring rhinitis. Clin. Exp. Allergy, 1998, v. 28, p. 220-227.
  5. Bachert C., Kempen M., Cauwenberg P. Regulation of proinflammatory cytokines in seasonal allergic rhinitis. Int. Arch. Allergy Immunol., 1999, v. 118, p. 375-379.
  6. Howarth P.H., Salagean M., Dokic D. Allergic rhinitis: not purely a histamine-related disease. Allergy, 2000, suppl. 64, p. 7-16.
  7. Togias A.G. Systemic immunologic and inflammatory aspects of allergic rhinitis. J. Allergy Clin. Immunol., 2000, v. 106, p. 247-250.
  8. Balfor-Linn I. Quantitative evaluation of nasal mucosa proteins. Clin. Exp. Allergy, 1999, v. 29, p. 719-720.
  9. Klimek L. Rasp G. Norm values for eosinophil cationic protein in nasal secretions: influence of specimen collection. Clin. Exp. Allergy, 1999, v. 29, p. 367-374.
  10. Marccuci F. , Sensi L.G., Migali E. et al. Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen allergic rhinitis and asthma. Allergy, 2001, v. 56, p. 231-236.
  11. Арефьева Н.И. Патогенез, клиника и лечение различных форм ринита и риносинуита с рецидивирующим течением. Автореф. диссертация д-ра мед. наук. М., 1990, 24 с.
  12. Park Y.-J., Repka-Ramirez M., Naranch K. et al. Nasal lavage concentrations of free hemoglobin as a marker of microepistaxis during nasal provocation testing. Allergy, 2001, v. 57, p. 377-384.
  13. Biedlingmaier J.F., Trifillis A. Comparison of CT scan and electron microscopic findings on endoscopically harvested middle turbinates. Otolaryngol. Head Neck Surg., 1998, v. 118, p. 165-173.
  14. Диагностика и лечение аллергического ринита, и его влияние на астму. Руководство для врачей. Материалы отчета ARIA EAACI в сотрудничестве с ВОЗ. М., 2001, 24 с.
  15. Мокроносова М.А., Кочетова Ю.И., Мац А.Н. Уровень свободного гемоглобина в назальном секрете в диагностике аллергического ринита. Аллергология, 2004, № 4, с. 24-27.


Abstract - 4

PDF (Russian) - 0


  • There are currently no refbacks.

Copyright (c) 2007 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies