ATOPIC DISEASES WITHOUT SYSTEMIC SENSIBILIZATION



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Abstract

The diagnosis of allergic disease related to the group of immediate hypersensitivity involves confirmation of IgE sensitization: positive skin tests with the suspected allergen and/or detection of allergen-specific IgE. Research over the past decades showed that IgE synthesis may occur exclusively in the tissues of the affected organ and derived allergen-specific antibodies may not enter the systemic circulation. In contrast to «atopy», this concept of local sensitization was termed «entopy». local production of IgE was detected in more then 47% of adults previously diagnosed as having non-allergic rhinitis. besides the nasal mucosa, local sensitization was found in lymphoid tissues of nasopharyngeal ring, bronchial mucosa in some patients with non-atopic asthma, esophageal mucosa in patients with eosinophilic esophagitis. The processes of local immune response is currently studied and probably one day the accumulated data will swing our understanding of atopic sensitization, that will be reflected in classification and therapeutic approaches.

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About the authors

D S Korostovtsev

Saint-Petersburg State pediatric medical university

Russia

L A Galenko

Saint-Petersburg State pediatric medical university

Email: l.galenko@gmail.com
Russia

O V Trusova

Saint-Petersburg State pediatric medical university

Russia

A V Kamaev

Saint-Petersburg State pediatric medical university

Russia

I V Makarova

Saint-Petersburg State pediatric medical university

Russia

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