Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 11, No 2 (2014)


Perioperative drug hypersensitivity reactions

Zhukova D.G., Fedenko E.S., Yudin A.A., Tsyvkina E.A.


Drug’s hypersensitivity reactions occurring during perioperative period are potentially life-threatening clinical conditions and require a different approach. This review covers current understanding of epidemiology and clinical sings of drug’s hypersensitivity reactions occurring during perioperative period. It focuses on reducing the risk of anaphylaxis during anesthesia.
Russian Journal of Allergy. 2014;11(2):3-10
pages 3-10 views

Polyfunctional antiallergic potencies of Д-antihistamine levocetirizine

Gushchin I.S.


The burden of allergic diseases worldwide is such that it represents a serious public health problem that attracts considerable efforts to identify effective and safe therapies. Antihistamines are an important part of the therapeutic options for allergic diseases. Levocetirizine is the R-enantiomer of cetirizine with pharmacokinetically and pharmacodynamically favourable characteristics. It is a potent inverse agonist of H 1-receptors with anti-inflammatory/anti-allergic properties. It appears to have grater in vivo H 1-receptor occupancy comparatively with other 2 nd generation H 1-antihistamines. This may confer an advantageous efficacy and safety profile. clinical trials indicate that it is safe and effective for the treatment of allergic rhinitis, chronic urticaria and some other allergic conditions in adults and children with a minimal number of untoward reactions. It is also becoming clearer that, in addition to its being a potent antihistamine, levocetirizine has several anti-inflammatory/anti-allergic effects that are observed at clinically relevant concentrations that may enhance its therapeutic benefit.
Russian Journal of Allergy. 2014;11(2):11-24
pages 11-24 views

The influence of climatic factors on the spectrum and structure of allergic diseases in the case of the Moscow region

Ilyina N.I., Luss L.V., Kurbacheva O.M., Nazarova E.V., Pavlova K.S.


Background. To study the features of the structure and spectrum of etiological allergens in allergic diseases in a changing climate taking into account the climatic characteristics the analysis of medical documentation and allergological examination of the Moscow region patients. Methods. The number of patient’s visits in the clinical department of the Institute of immunology, Moscow, Russia, for the fiveyear period (2008 to 2012) as well as the pollen monitoring data during the seasonal period from 2008 to 2012 were estimated. Results and conclusion. It was found that the debut of bronchial asthma in patients with pollinosis directly depends on a high pollen concentration in the atmospheric air (above 20 000 pollen grains per m3 of air). The influence of climatic and weather conditions on the formation, aggravation and severity of allergic diseases in the case of patients living in the Moscow region have been established.
Russian Journal of Allergy. 2014;11(2):25-31
pages 25-31 views

Results of pollen monitoring and features of seasonal allergic rhinitis in Samara

Manzhos M.V., Bahentsev K.Y., Khabibulina L.R., Vlasova N.V., Kavelenova L.M.


Background. The objective was to study the taxonomic diversity of the concentration of pollen, its changes and peculiarities of the course of seasonal allergic rhinitis in Samara city. Methods. Pollen was located with gravimetric method on the glass, covered with a special mixture. Clinical and allergological examination conducted among 775 children aged from 5 to 18 years and 692 adults with symptoms of rhinitis. Results. Registered three periods of increase of concentration of pollen: spring period, summer period and summer-autumn period. The major taxa in the spring was pollen Populus - 49% and Betula - 27% during this period. In the summer period dominated pollen was Pinus - 37%, Poaceae - 28% and Betula - 22%. In summer-autumn period prevailed pollen grains Ambrosia - 63% and Artemisia - 10%, of the total number of pollen grains for this period. Clinical and allergological studies have shown that the proportion of patients with seasonal allergic rhinitis is 78% among the total number of patients with allergic rhinitis. Isolated form of seasonal allergic rhinitis was diagnosed in 22% of children and in 20% of adults. Patients of this group are allergic to pollen, weeds and compositae revealed in 68%, trees - 20%, cereals - 12% of cases. Conclusion. Qualitative and quantitative composition of aeropalynologic spectrum was established and showed the peculiarities of the course of seasonal allergic rhinitis in Samara city.
Russian Journal of Allergy. 2014;11(2):32-36
pages 32-36 views

New delivery device for inhaled drugs for bronchial asthma treatment. Multidose Easyhaler dry powder inhaler

Vilegzhanina T.G.


According to current conception of bronchial asthma treatment, the main goals are symptoms control and good life quality. Inhalation is the preferred route of drug administration for patients with airway diseases such as asthma. Inhalation delivers drugs directly to the airways and thereby the effective dose can be small compared with oral therapy (in 20 times), the risk of systemic side effects is reduced, it could be used for poorly soluble drugs which are not absorbed in the gastrointestinal canal. Inhalation is the route of drug administration and can be used for delivery of bronchodilators, mucolytics, steroids, and cromoglicate acid drugs as well.
Russian Journal of Allergy. 2014;11(2):37-40
pages 37-40 views

Peculiarities of inflammatory process and markers of inflammation in patients with bronchial asthma and COPD

Fedoseev G.B., Trofimov V.I., Timchik V.G., Negrutsa K.V., Gorovneva E.V., Razumovskaya T.S., Alexandrin V.A., Kryakunov K.N., Filippova N.A., Birulya I.V.


The investigation concerned the diagnostic value of following inflammation markers in patients with mild or moderate bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), chronic bronchitis and pneumonia: expired air nitric oxide (Feno) and serum levels of α 1-antitripsin and neutrophilic elastase. 93 patients were included: 6 with mild BA, 11 - with moderate BA, 17 - with mild BA and chronic bronchitis, 25 - with moderate BA and COPD, 25 - with COPD, 9 - with pneumonia. The control group consisted of 21 healthy donors. We revealed that Feno, α 1-antitripsin and neutrophilic elasthase indicate the presence of the inflammation: Feno elevation mostly related to allelrgic one, α 1-antitripsin and neutrophilic elasthase - to infection-dependent inflammation. Treatmentinduced remission of the disease leads to the decrease of α 1-antitripsin and neutrophilic elasthase, but levels are not reaching the normal values. This confirms the presence of airways inflammation during clinical remission of the disease. Elevated levels of α 1-antitripsin and neutrophilic elasthase are associated with the decreased forced expiratory volume during the first second (FEV 1 - % to the predicted values).
Russian Journal of Allergy. 2014;11(2):44-58
pages 44-58 views

Diagnosis and treatment of complicated forms of atopic dermatitis in children

Smirnova G.I.


The article deals with a clinical and diagnostic criteria and character of skin lesions in children with atopic dermatitis and second infection. Various factors are analysed that influence the course of the disease at different infections, the basic principles of therapy of atopic dermatitis with infections are discussed.
Russian Journal of Allergy. 2014;11(2):59-66
pages 59-66 views

Allergic rhinitis in pediatric practice

Karpova E.P.


Allergic rhinitis (AR) in children is one of the most widespread diseases. children suffering from AR have to be under allergist and otorhinolaryngologist observation as well. there is a variety of medicine groups for AR treatment, but not all of them are preparations of choice from a position of evidential medicine. the most effective are intranasal glucocorticosteroids, especially from the last generation, having clinical efficiency and higher profile of a safety.
Russian Journal of Allergy. 2014;11(2):67-72
pages 67-72 views

Alvesco: new molecule in new inhalation device - new possibilities in asthma control

Ilina N.I., Latysheva E.A.


The article presents the data about the new molecule inhaled glucocrticosteroid (iGCS) - ciclesonide in a new delivery device pMDA-HFA. A detailed analysis of the main characteristics of the drug molecules and means of their delivery was conducted according to international data. The results of observational study of the use of Alvesco in bronchial asthma patients in the real clinical practice of the Institute of Immunology are discussed.
Russian Journal of Allergy. 2014;11(2):73-78
pages 73-78 views

Combination of children’s pharyngeal tonsil hyperplasia and allergic rhinitis

Belov V.A.


The prevalence of adenoid hypertrophy and allergic rhinitis data based on the study of the overall medical examination of children in 2002 and the further monitoring of children in Russia in 2005-2009 (population study) are presented. The main principles of therapy are specified. Special attention has been paid to the use of Vibrocil combination drug among children, which contains antihistamine component Dimethindene, and decongestant Phenylephrine.
Russian Journal of Allergy. 2014;11(2):79-82
pages 79-82 views

Skin barrier: structure and immune changes in common skin diseases

Ionescu M.A.


Skin barrier must be seen as a complex structure with complex functions involving hydrolipidic film, stratum corneum, the intercellular cement and also immunologic barrier as innate adaptive immune system (as Toll Like Receptors - TLR), complement, dendritic cells and antigen-related responses. Skin barrier changes are seen in different skin diseases as atopic dermatitis, rosacea , contact dermatitis and others. In the first part of this article we describe skin physical barrier and its key elements roles (ceramides, filaggrin, tight junctions and claudins), the clinical consequences of barrier damages in different common skin diseases (atopic dermatitis, xeroses of different origins). Immune skin barrier is complex and in this first part of the article we focus only on innate immune system skin represented by Toll Like Receptors and their role in the synthesis of antimicrobial peptides (AMP). In the second part we present ex vivo and in vivo studies on skin physical barrier repair and improvement of AMP expression in human skin by modulating TLR2. The management of human skin barrier damages and their repair by active topicals must by a holistic approach, taking in account the complexity of physical and of immune barriers of the skin.
Russian Journal of Allergy. 2014;11(2):83-89
pages 83-89 views
pages 92-96 views

Congresses, Conferences

- -.
Russian Journal of Allergy. 2014;11(2):97-97
pages 97-97 views

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies