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Chitinase-like protein YKL-40 from nasal mucosa as a biomarker of allergic rhinitis
- Authors: Tyurin Y.A1,2, Sukmanskaya EO1, Kulikov SN1, Fassakhov RS1
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Affiliations:
- Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
- Kazan State Medical Universityte, Russia
- Issue: Vol 9, No 4 (2012)
- Pages: 13-17
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/677
- DOI: https://doi.org/10.36691/RJA677
- ID: 677
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Abstract
Background. Chitinase-like protein YKL-40 plays an important role in human atopic diseases. The aim of this study was to determine of the level of chitinase-like protein YKL-40 in the secretions of nasal mucosa of patients with chronic allergic rhinitis. Methods. Samples of allergic nasal mucosa were obtained from twelve patients with perennial allergic rhinitis. Measurement of nasal YKL-40 levels was performed with modification in duplicate using commercially available ELISA kits for YKL-40. The amount of nasal eosinophils and neutrophils were also determined. Results. There were significant differences between healthy volunteers and patients with allergic rhinitis for mucosal YKL-40 levels and the amount of nasal eosinophil and neutrophil cells, which have some characteristics closely associated with allergic response. The nasal YKL-40 levels in patients with allergic rhinitis were in tens times more higher than those in controls. Conclusion. Thus, we conclude that the level of chitinase-like protein YKL-40 was upregulated in allergic nasal mucosa compared with normal nasal mucosa, suggesting their roles in the pathogenesis of allergic rhinitis.
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About the authors
YU A Tyurin
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia; Kazan State Medical Universityte, Russia
E O Sukmanskaya
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
S N Kulikov
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
R S Fassakhov
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
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