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Chitinase-like protein YKL-40 from nasal mucosa as a biomarker of allergic rhinitis
- Authors: Tyurin Y.A1,2, Sukmanskaya EO1, Kulikov SN1, Fassakhov RS1
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Affiliations:
- Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
- Kazan State Medical Universityte, Russia
- Issue: Vol 9, No 4 (2012)
- Pages: 13-17
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2012
- URL: https://rusalljournal.ru/raj/article/view/677
- DOI: https://doi.org/10.36691/RJA677
- ID: 677
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Abstract
Background. Chitinase-like protein YKL-40 plays an important role in human atopic diseases. The aim of this study was to determine of the level of chitinase-like protein YKL-40 in the secretions of nasal mucosa of patients with chronic allergic rhinitis. Methods. Samples of allergic nasal mucosa were obtained from twelve patients with perennial allergic rhinitis. Measurement of nasal YKL-40 levels was performed with modification in duplicate using commercially available ELISA kits for YKL-40. The amount of nasal eosinophils and neutrophils were also determined. Results. There were significant differences between healthy volunteers and patients with allergic rhinitis for mucosal YKL-40 levels and the amount of nasal eosinophil and neutrophil cells, which have some characteristics closely associated with allergic response. The nasal YKL-40 levels in patients with allergic rhinitis were in tens times more higher than those in controls. Conclusion. Thus, we conclude that the level of chitinase-like protein YKL-40 was upregulated in allergic nasal mucosa compared with normal nasal mucosa, suggesting their roles in the pathogenesis of allergic rhinitis.
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About the authors
YU A Tyurin
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia; Kazan State Medical Universityte, Russia
E O Sukmanskaya
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
S N Kulikov
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
R S Fassakhov
Kazan Cientific Research Institute of Epidemiology and Microbiology, Russia
References
- Reese T.A., Liang H.E., Tager A.M. et al. Chitin induces accumulation in tissue of innate immune cells assotiated with allergy. Nature. 2007, v. 447, p. 92-96.
- Zhao J., Zhu H., Wong C.H. et al. Increased lungkine and chitinase levels in allergic airway inflammation: a proteomics approach. Proteomics. 2005, v. 5, p. 2799-2807.
- Homer R.J., Zhu Z., Cohn L. et al. Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Am. J. Physiol. Lung. Cell Mol. Physiol. 2006, v. 291, p. L502-L511.
- Zhao J., Yeong L.H., Wong W.S. Dexamethasone alters bronchoalveolar lavage fluid proteome in a mouse asthma model. Int. Arch. Allergy Immunol. 2007, v. 142, p. 219-229.
- Arora M., Chen L., Paglia M. et al. Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proc. Natl. Acad. Sci. USA. 2006, v. 103, p. 7777-7782.
- Elias J.A., Homer R.J., Hamid Q., Lee C.G. Chitinases and chitinase-like proteins in Th2 inflammation and asthma. J. Allergy Clin. Immunol. 2005, v. 116, p. 497-500.
- Куликов С.Н., Тюрин Ю.А., Долбин Д.А., Фассахов Р.С. Хитин и хитиназы при аллергических реакциях. Росс. Аллергол. Журн. 2009, № 1, с. 18-23.
- Kuepper M., Bratke K., Virhow J.C. Chitinase-like protein and asthma. New England. J. Med. 2008, v. 358, p.1073-1075.
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