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THE CLINICAL ROLE OF COMPONENT DIAGNOSTICS OF PEANUT ALLERGY AMONG CHILDREN WITH ALLERGIC DISEASES
- Authors: Shulyaeva AM1, Pampura AN1, Okuneva TS1, Shabelnikova EI1
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Affiliations:
- Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 11, No 6 (2014)
- Pages: 41-46
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/511
- DOI: https://doi.org/10.36691/RJA511
- ID: 511
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Abstract
Background. To determine the clinical significance of IgEmediated sensibilization to recombinant peanut allergens. Materials and methods. We examined 30 children with allergic diseases and sensibilization to whole peanut allergen. All children passed through allergological examination, including determination of specific IgE (method of Measurement CAP 100 Phadia, Switzerland) to recombinant peanut allergens: Ara h1, Ara h2, Ara h3, Ara and Ara h8, h9. Results. A wide variation of combinations of sensibilization to various peanut allergens was found. Sensibilization to rAra hi allergen was found in 40% of cases, to rAra h2 - in 36,6%, to rAra h3 - in 33%, to rAra h8 - in 60%, to rAra h9 in 56,6% of cases. Their clinical significance was 36,6% (rAra hi), 26% (rAra h2), 23% (rAra h3), 33% (rAra h8), 36% (rAra h9). Monosensibilization to peanut allergens rAra hi, 8 and 9 was identified in 26,6% of cases. The interrelation of rAra h2 and rAra h8 with atopic dermatitis and rAra h3 with asthma was found. Conclusion. Component diagnostics of peanut allergens has high diagnostic significance in further administration of elimination diets.
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About the authors
A M Shulyaeva
Russian National Research Medical University named after N.I. Pirogov
Email: anna.guseva.doc@mail.ru
A N Pampura
Russian National Research Medical University named after N.I. Pirogov
T S Okuneva
Russian National Research Medical University named after N.I. Pirogov
E I Shabelnikova
Russian National Research Medical University named after N.I. Pirogov
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