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THE CLINICAL ROLE OF COMPONENT DIAGNOSTICS OF PEANUT ALLERGY AMONG CHILDREN WITH ALLERGIC DISEASES
- Authors: Shulyaeva AM1, Pampura AN1, Okuneva TS1, Shabelnikova EI1
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Affiliations:
- Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 11, No 6 (2014)
- Pages: 41-46
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2014
- URL: https://rusalljournal.ru/raj/article/view/511
- DOI: https://doi.org/10.36691/RJA511
- ID: 511
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Abstract
Background. To determine the clinical significance of IgEmediated sensibilization to recombinant peanut allergens. Materials and methods. We examined 30 children with allergic diseases and sensibilization to whole peanut allergen. All children passed through allergological examination, including determination of specific IgE (method of Measurement CAP 100 Phadia, Switzerland) to recombinant peanut allergens: Ara h1, Ara h2, Ara h3, Ara and Ara h8, h9. Results. A wide variation of combinations of sensibilization to various peanut allergens was found. Sensibilization to rAra hi allergen was found in 40% of cases, to rAra h2 - in 36,6%, to rAra h3 - in 33%, to rAra h8 - in 60%, to rAra h9 in 56,6% of cases. Their clinical significance was 36,6% (rAra hi), 26% (rAra h2), 23% (rAra h3), 33% (rAra h8), 36% (rAra h9). Monosensibilization to peanut allergens rAra hi, 8 and 9 was identified in 26,6% of cases. The interrelation of rAra h2 and rAra h8 with atopic dermatitis and rAra h3 with asthma was found. Conclusion. Component diagnostics of peanut allergens has high diagnostic significance in further administration of elimination diets.
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About the authors
A M Shulyaeva
Russian National Research Medical University named after N.I. Pirogov
Email: anna.guseva.doc@mail.ru
A N Pampura
Russian National Research Medical University named after N.I. Pirogov
T S Okuneva
Russian National Research Medical University named after N.I. Pirogov
E I Shabelnikova
Russian National Research Medical University named after N.I. Pirogov
References
- Grundy J., Matthews S., Bateman B. Rising prevalence of allergy to peanut in children. Journal Allergy Clinical Immunology. 2002, v. 5, p. 784-789.
- Sicherer S.H., Monoz-Furlong A., De Simone J. The US peanut and tree Nut Allergy Registry: characteristics of reactions in schools and day care. J. Pediatrics. 2001, v. 4, p. 560-565.
- Сайт статистического отдела продовольственной и сельскохозяйственной организации объединенных наций. http://www.faostat.fao.org.
- Grundy J., Matthews S., Bateman B. Rising prevalence of allergy to peanut in children. Journal Allergy Clinical Immunology. 2002, v. 5, p. 784-789.
- Riecken S., Linder B., Petersen A. et al. Purification and characterization of natural Ara h8, Bet v 1 homologous allergen from peanut, provides a novel isoform. Biology and Chemistry. 2008, v. 4, p. 415-423.
- Gupta R., Sheikh A., Strachan D.P. et al. Time trends in allergic disorders in the UK. Thorax. 2007, v. 1, p. 91-96.
- Mullins R.J., Dear K., Tang M.L. Characteristics of childhood peanut allergy in the Australian. 1995-2007. Journal of Allergology and Clinical Immunology. 2009, v. 123, p. 689-693.
- Сайт университета по изучению бронхиальной астмы и других аллергических заболеваний. США, Северная Каролина. www.carolinaastma.com.
- Shreffler W.G., Beyer K., Chu T.H. et al. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. Journal of Allergology and Clinical Immunology. 2004, v. 4, p. 776-782.
- Koppelman S., Vlooswijk R.A., Knippels L.M. et al. Quantification of major peanut allergens Ara h1 and Ara h2 in the peanut varieties Runner, Spanish, Virginia, and Valencia, bred in different parts of the world. Allergy. 2001, v. 56, p. 132-137.
- Burks A.W., Shin D., Cockrell G. et al. Mapping and mutational analysis of the IgE-binding epitopes on Ara h1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur. J. Biochem. 1997, v. 245, p. 9.
- Burks A.W., Sampson H.A., Bannon G.A. Peanut allergens. Allergy. 1998, v. 53, p. 725-730.
- Sicherer S.H., Sampson H.A. Peanut allergy: Emerging concepts and approaches for an apparent epidemic. J. Allergy Clin. Immunol. 2007, v. 120, p. 491-503.
- Allergen Nomenclature (IUIS Allergen Nomenclature Sub-Committee). http://www.allergen.org/search.php?Al-lergensource=Arachis+hypogaea.
- Федорова О.С., Огородова Л.М., Федотова М.М. и соавт. Распространенность пищевой аллергии к арахису и фундуку у детей в Томской области. Вопросы питания. 2014, № 1, с. 48-54.
- Атопический дерматит и инфекции кожи у детей: диагностика, лечение и профилактика. Научно-практическая программа Союза педиатров России. Пособие для врачей. М., 2004, 104 с.
- Бронхиальная астма у детей: диагностика, лечение и профилактика. Научно-практическая программа. Под ред. А.А. Баранова, И.И. Балаболкина. М., 2004, 48 с.
- Крапивница и ангиоотек: Рекомендации для практических врачей. Российский национальный согласительный документ. Под ред. И.С. Гущина, Н.И. Ильиной. М., «Фармарус Принт Медиа». 2007, 128 с.
- Cruz A., Popov T., Pawankar R. et al. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA2LEN. Allergy. 2007, v. 62, p. 1-41.
- Sampson H.A., Munoz-Furlong A., Campbell R. et al. Second symposium on the definition and management of anaphylaxis: summary report - Second National Institute of Allergy and Infectious Disease. Food Allergy and Anaphylaxis Network symposium. J. Allergy Clin. Immunol. 2006, v. 117, p. 391-397.
- Stalder J.F., Taieb A. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1993, v. 186, p. 23-31.
- Taylor S.L., Hefle S.L., Bindslev-Jensen C. et al. Factors affecting the determination of threshold doses for allergenic foods - How much food is too much. Journal of Allergy and Clinical Immunology. 2002, v. 109, p. 24-30.
- Nicolaou N., Poorafshar M., Murray C. et al. Allergy of tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. Journal of Allergology and Clinical Immunology. 2010, v. 125, p. 191-197.
- Shreffler W.G., Beyer K., Chu T. et al. Micriarrey immunoassay: association in clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. Allergology and Clinical Immunology. 2004, v. 113, p. 776-782.
- Asarnoj A., Moverare R., Ostblom E. et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization 8 year olds. Allergy. 2010, v. 65, p. 1189-1195.
- Lauer I., Dueringer N., Pokoj S. et al. The non-specific lipid transfer protein, Ara h9, is an important allergen peanut. Clinical Expert Allergy. 2009, v. 39, p. 1427-1437.
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