Clinical and allergological characteristic of children with allergic rhinitis receiving allergen-specific immunotherapy in Altai region

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


The purpose of this study. To investigate clinical characteristics of the allergic rhinitis in children receiving allergen-specific immunotherapy. Methods. The epidemiologic observational multicenter study was conducted with the allergists of Altai region. The participating allergists filled out the specially designed medical record card on children with allergic rhinitis receiving ASIT. The study lasted from October 2013 to March 2014. Results. Allergists have filled out medical record cards of 165 children with allergic rhinitis receiving ASIT. The average age of children was 10,5±2,3 years, with the average of 4,8±2,5 years of allergic rhinitis prior to the start of ASIT. 159 (96,2%) children had moderate/severe allergic rhinitis, and 121 (73,3%) children had persistent allergic rhinitis. In 123 (74,5%) children rhinitis was accompanied by allergic conjunctivitis, and in 70 (42,2%) children - by bronchial asthma. 69 (41,8%) children receiving ASIT were mono-sensitized, 96 (58,2%) children were polysensitized. 48,5% of children were sensitized to house dust mites, 63,6% to tree pollen, 48,5% to meadow grass pollen, 30,9% to weed pollen, and in 21,8% sensitization to epidermal allergens was found. Conclusion. The findings of the study showed that in most cases (96,2%), children with allergic rhinitis receiving ASIT had moderate/severe rhinitis and in 73,3% symptoms were persistent. In 74,5% of cases, allergic rhinitis was accompanied by allergic conjunctivitis. Most part of children receiving ASIT had multiple sensitization (58,2%). Also a delayed beginning of ASIT was observed - 4,8±2,5 year from primary diagnosis to ASIT initiation.

Full Text

Restricted Access

About the authors

N V Shakhova

Altai State Medical University

Barnaul, Russia

V V Gordeev

Altai State Medical University

Barnaul, Russia

U F Lobanov

Altai State Medical University

Barnaul, Russia

T S Ardatova

Altai State Medical University

Barnaul, Russia

M V Surcova

City Clinical Children's Hospital No. 7

Barnaul, Russia


  1. Гущин И.С., Курбачева О.М. Аллергия и аллергенспеци-фическая иммунотерапия. М., «Фармарус Принт Медиа». 2010, 179 с.
  2. Abramson M., Puy R., Weiner J. Immunotherapy in asthma: an updated systematic review. Allergy. 1999, v. 54. p. 1022-1041.
  3. Malling H.J. Allergen immunotherapy efficacy in rhinitis and asthma. Allergy Clin. Immunol. Int. J. World Allergy Org. 2004, v. 16, p. 92-95.
  4. Курбачева О.М. Аллерген-специфическая иммунотерапия. Рос. Аллергол. Журн. 2004, № 2, с. 32-54.
  5. Frolund L., Durham S.R., Calderon M. et al. Sustained Effect of SQ-standardized grass allergy immunotherapy tablet on rhonoconjunctivitis quality of life. Allergy. 2010, v. 65, р. 753.
  6. Calamita Z., Saconato H., Peala A. et al. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006, v. 61, р. 1162-1172.
  7. Didier A., Malling H.J., Worm M. et al. Optimal dose, efficacy and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J. Allergy Clin. Immunol. 2007, v. 120, р. 1338-1345.
  8. Moller C., Dreborg S., Ferdousi H.A. et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-stady). J. Allergy. Clin. Immunol. 2002, v. 109, p. 251-256.
  9. Yilmaz M., Bingol G., Altindas D. et al. Effect of SIT on quality of life. Allergy. 2000, v. 55, р. 302-309.
  10. Шахова Н.В., Гордеев В.В., Лобанов Ю.Ф. и соавт. Влияние подкожной аллерген-специфической иммунотерапии экстрактом аллергенов пыльцы деревьев, адсорбированной на фосфате кальция, на качество жизни детей с аллергическим риноконъюнктивитом: результаты 2,5-летнего наблюдения. Рос. Аллергол. Журн. 2014, № 1, с. 33-39.
  11. Шахова Н.В., Гордеев В.В., Лобанов Ю.Ф. и соавт. Эффективность подкожной аллерген-специфической иммунотерапии экстрактом аллергенов пыльцы деревьев, адсорбированным на фосфате кальция, при аллергическом риноконъюнктивите: результаты 2-летнего наблюдения. Педиатрическая фармакология. 2014, № 3, с. 31-37.
  12. Курбачева О.М., Павлова К.С., Ильина Н.И. и соавт. Эффективность проведения аллерген-специфической иммунотерапии препаратом «Фосталь» у больных поллинозом. Рос. Аллергол. Журн. 2009, № 3, с. 27-31.
  13. Malling H.-J., Weeke B. Position paper: Immunotherapy. (EAACI) The European Academy of Allergology and Clinical Immunology. Allergy. 1993, v. 48, р. 1-42.
  14. Bousquet, J., Lockey R.F., Malling H.J. at al. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy. 1998, v. 53, р. 1-42.
  15. Bousquet J., van Cauwenberge P., Khaltaev N. et al. Allergic rhinitis and its impact on asthma (ARIA workshop report). J. Allergy Clin. Immunol. 2001, v. 108, p. 147-334.
  16. Bousquet J., Khaltaev N., Cruz A.A. et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with World Health Organization, GA2LEN and AllerGen). Allergy. 2008, v. 63, p. 8-160.
  17. Ziberbier T., Bachert C., Bousquet P.J. et al. Position paper: GA2LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma. J. Allergy. 2010, v. 65, p. 525-1530.
  18. Европейская декларация по иммунотерапии. Часть I. Рос. Аллергол. Журн. 2012, № 2, с. 45-51.
  19. Migueres M., Fontaine J.F., Haddad T et al. Characteristics of patients with respiratory allergy in France and factors influencing immunotherapy prescription: a prospective observational study (REALIS). Int. J. Immunopathol. Pharmacol. 2011, v. 24, p. 387-400.
  20. Ibero M., Justicia J.L., Alvaro M. et al. Diagnosis and treatment of allergicrhinitis in children: results of the PETRA study. Int. J. Immunopathol. Pharmacol. 2011, v. 24, p. 387-400.
  21. Valero A., Chivato T., Jose L. et al. Diagnosis and treatment of grass pollen-induced allergic rhinitis in specialized current clinical practice in Spain. J. Allergy and Asthma Proceedings. 2011, v. 32, р. 384-389.
  22. Шахова Н.В., Лобанов Ю.Ф., Сидоренкова Н.Б. и соавт. Анализ врачебных назначений противоаллергических лекарственных средств в Алтайском крае при аллергическом рините у детей. Журнал «Мать и дитя в Кузбассе». 2014, № 2, с. 148-153.



Abstract - 16

PDF (Russian) - 0


Article Metrics

Metrics Loading ...


Copyright (c) 2015 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies