Oropharyngeal microbiota features in patients with bronchial asthma, depending on the severity of the disease and the level of control

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Abstract


This paper presents the results of the comparative analysis of the taxonomic composition of oropharyngeal microbiota obtained by swab from the back of the throat of the 2 groups of patients with bronchial asthma: patients with mild persistent controlled or partially controlled asthma, and patients with severe uncontrolled asthma. The swab collecting procedure was performed in a stable period of the disease without exacerbations episodes and systemic antibiotic therapy courses within the previous 4 weeks or more. Taxonomic identification of the microbiota was performed using conserved regions of bacterial 16S rRNA sequencing. The study revealed a number of differences in the representation of the identified microorganisms that make up the oropharyngeal microbiota in patients with asthma, depending on the severity of asthma, the level of control, other clinical and anamnestic features.

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About the authors

S V Fedosenko

Siberian State Medical University

Email: s-fedosenko@mail.ru

L M Ogorodova

Siberian State Medical University


A S Popenko

Research Institute for Physico-Chemical Medicine, FMBA


V A Petrov

Siberian State Medical University


A V Tyacht

Research Institute for Physico-Chemical Medicine, FMBA


I V Saltykova

Siberian State Medical University


I A Deev

Siberian State Medical University


E S Kulikov

Siberian State Medical University


N A Kirillova

Siberian State Medical University


V M Govorun

Research Institute for Physico-Chemical Medicine, FMBA; Kazan (Volga) Federal University


E S Kostryukova

Research Institute for Physico-Chemical Medicine, FMBA; Kazan (Volga) Federal University


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