Email this article 
IgE-AB to animals molecular allergens in patients with respiratory allergy
- Authors: Mokronosova MA1, Bass EA1, Bala AM2, Zheltikova TM1
-
Affiliations:
- Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
- Helix Laboratory Service
- Issue: Vol 12, No 2 (2015)
- Pages: 25-28
- Section: Articles
- URL: https://rusalljournal.ru/raj/article/view/446
- DOI: https://doi.org/10.36691/RJA446
- ID: 446
Cite item
Open Access
Access granted
Abstract
Background. The purpose of this study was to identify IgE-antibodies to the major and minor allergenic components of pets in the blood serum of patients with bronchial asthma and/or allergic rhinitis (BA/AR). Methods. The study included 327 patients from Moscow and St. Petersburg. All of them were detected for specific IgE-antibodies (IgE-AB) to the animal allergens by ImmunoCAP® (ThermoFisherScientific, Sweden). 105 patients wanted to detect IgE-AB to the main animal allergens molecules ImmunoCAP ISAC® (ThermoFisherScientific, Sweden). Results. In the sera of 327 patients IgE-AB to cat’s (62%) allergen dominated. IgE-antibodies to dog’s, house dust mites (D.pteronyssinus, D. farinae), mold fungi, horses and rodents allergens were found in 2,6-31 times less. IgE-AB to uteroglobin (rFel d 1), major cat allergen, was detected in 80% of patients (84/105). The detection rate of IgE-AB to other cat allergens was 4,2-8 times lower (rFel d 2 - 10%, nFel d 4 - 19%). IgE-AB to major dog allergen rCan f 1 was detected in 39% of patients (41/105). Positive level of IgE-AB to other dog allergens was detected in 2,2-4,9 times lower (rCan f 2 - 8%, nCan f 3 - 9%, rCan f 5 - 18%). Positive level of IgE-AB to lipocalin was assayed in 6% of patients, to serum albumin - in 7%. Conclusion. Prevalence of IgE-AB to cat and dog allergens was almost 3 times higher than the frequency of detection of IgE-AB to house dust mite allergens in citizens of Moscow and S. Petersburg. The frequency of IgE-AB to rFel d 1 was dominated and detected 2 and 4-11 times often than to rCan f 1 and other animal allergens consequently.
Keywords
Full Text
About the authors
M A Mokronosova
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
E A Bass
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
A M Bala
Helix Laboratory ServiceSt. Petersburg, Russia
T M Zheltikova
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
Email: t-zheltikova@yandex.ru
References
- Melen E., Wickman M., Nordvall S.L. Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children. Allergy. 2001, v. 56, p. 646-652.
- Surdu S., Montoya L.D., Tarbell A. Childhood asthma and indoor allergens in Native Americans in New York. Environmental Health: A Global Access Science Source. 2006, v. 5, p. 22.
- Munthe-Kaas M.C., Bertelsen R.J., Torjussen T.M. et al. Pet keeping and tobacco exposure influence CD14 methylation in childhood. Pediatr. Allergy Immunol. 2012, v. 23, p. 747-754.
- Nicolaou N., Yiallouros P., Pipis S. et al. Domestic allergen and endotoxin exposure and allergic sensitization in Cyprus. Pediatr. Allergy Immunol. 2006, v. 17, p. 17-21.
- Ronmark E., Bjerg A., Perzanowski M. et al. Major increase in allergic sensitization in school children from 1996 to 2006 in Northern Sweden. J. Allergy Clin. Immunol. 2009, v. 124, p. 357-363.
- Gusareva E.S., Bragina E.J., Deeva E.V. et al. Cat is a major allergen in patients with asthma from west Siberia. Allergy. 2006, v. 61, p. 509-510.
- Огородова Л.М., Камалтынова Е.М., Деев И.А. и соавт. Эпидемиология аллергического ринита у детей Томска и сельской местности Томской области. Вестник оториноларингологии. 2010, № 3, c. 19-23.
- AWAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organization Journal. 2013, v. 6, р. 17.
- Nilsson O.B., Binnmyr J., Zoltowska A. et al. Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse. Allergy. 2012, v. 67, p. 751-757.
- Желтикова Т.М., Мокроносова М.А. Распространение клещей абарно-зернового комплекса и их роль в сенсибилизации жителей г. Москвы. Бюлл. эксп. биологии и мед. 1991, № 4, с. 396-398.
- Gent J.F., Belanger K., Triche E.W. et al. Association of pediatric asthma severity with exposure to common household dust allergens. Environ. Res. 2009, v. 109, p. 768-774.
- Larenas-Linnemann D., Michels A., Dinger H. et al. Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub) tropics. Clin. Transl. Allergy. 2014, v. 4, p. 20-30.
- Sanchez J., Diez S., Cardona R. Frequency of sensitization to animals in a tropical area. Rev. Allerg. Mex. 2014, v. 61, p. 81-89.
- Nordlund B., Konradsen J.R., Kull I. IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. Allergy. 2012, v. 67, p. 661-669.
- Gulbahar O., Sin A., Mete N. et al. Sensitization to cat allergens in non-cat owner patients with respiratory allergy. Ann. Allergy Asthma Immunol. 2003, v. 90, p. 635-639.
- Kelly L.A., Erwin E.A., Platts-Mills T.A. The indoor air and asthma: the role of cat allergens. Curr. Opin. Pulm. Med. 2012, v. 18, p. 29-34.
- Morgenstern J.P., Griffith I.J., Brauer A.W. et al. Amino acid sequence of Fel d 1, the major allergen of the domestic cat: Protein sequence analysis and cDNA cloning. Proc. Natl. Acad. Sci. USA. 1991, v. 88, p. 9690-9694.
- Schmitz N., Dietmeier K., Bauer M. et al. Displaying Fel d 1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy. J. Exp. Med. 2009, v. 206, p. 1941-1955.
- Emara M., Royer P.J., Abbas Z. et al. Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity. J. Biol. Chem. 2011, v. 286, p. 13033-13040.
- Gronlund H., Saarne T., Gafvelin G., van Hage M. The major cat allergen, Fel d 1, in diagnosis and therapy. International Archives of Allergy and Immunology. 2010, v. 151, p. 265-274.
- Abramson S.L., Turner-Henson A., Anderson L. et al. Allergens in school settings: results of environmental assessments in 3 city school systems. J. School Health. 2006, v. 76, p. 246-249.
- Permaul P., Hoffman E.B., Fu C. et al. Allergens in urban schools and homes of children with asthma. Pediatr. Allergy Immunol. 2012, v. 23, p. 543-549.
Supplementary files
