Markers of endothelial dysfunction in bronchial asthma patients

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


Objective. To identify endothelial dysfunction (ED) in patients with bronchial asthma (BA) in the acute phase, to establish the relationship between levels of homocysteine (HC) and endothelin-1 (ET-1) in the blood, and the causes of the disease. Materials and methods. 32 young patients in acute phases of bronchial asthma divided into three groups depending on the cause of bronchial asthma, and 10 healthy individuals were included in the study. Respiratory function assessed by spirometry with bronchodilatation test, serum endothelin-1 level was determined with immunofermental analysis, homocysteine level was determined with plasma liquid chromatography method. The results. There was a significant statistical difference between groups in terms of homocysteine, endothelin-1 levels in blood. Significant positive correlation between the levels of homocysteine and endothelin-1 in patients with allergic bronchial asthma and a significant negative correlation between the marker levels of endothelial dysfunction and lung function were identified. Conclusion. Acute phase of asthma accompanied by endothelial dysfunction, characterized by different levels of homocysteine and endothelin-1 in blood, depending on the genesis of the disease.

Full Text

Restricted Access

About the authors

N M De Silva

First pavlov State Medical University

Email: tawa17mnm@yandex.ru

V I Nemtsov

First pavlov State Medical University


V I Trofimov

First pavlov State Medical University


References

  1. GINA http://www.ginasthma.org/local/uploads/files/GINA_Russian_2011.pdf.
  2. Затейщикова А.А., Затейщиков Д.А. Эндотелиальная регуляция сосудистого тонуса: методы исследования и клиническое значение. Кардиология. 1998, № 9, с. 68-78.
  3. Собко Е.А., Крапошина А.Ю. Эндотелиальная дисфункция у больных бронхиальной астмой. Рос. Аллергол. Журн. 2013, № 2, с. 29-36.
  4. Petrishchev N.N., Trofimov V.I., Pluzhnikov M.S. et al. Mechanisms of vasomotor form of endothelial dysfunction in bronchial asthma. Chinese Journal of Pathophysiology. 2006, v. 22, р. 480.
  5. Болдырев А.А., Владыченская Е.А. Влияние гомоцистеина на дыхательный взрыв нейтрофилов, вызванный индуктором хемотаксиса fMLP. Нейрохимия. 2009, № 1, с. 72-78.
  6. Rubanyi G.M., Polokoff M.A. Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol. Rev. 1994, v. 46, р. 325-415.
  7. Stewart D.J., Levy R.D., Cernacek P., Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Annals of internal medicine. 1991, v. 114, р. 464-469.
  8. Vancheeswaran R., Magoulas T., Efrat G. et al. Circulating endothelin-1 levels in systemic sclerosis subsets a marker of fibrosis or vascular dysfunction? The Journal of Rheumatology. 1994, v. 21, р. 1838-1844.
  9. Tonnessen T., Giaid A., Saleh D. et al. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circulation research. 1995, v. 76, р. 767-772.

Statistics

Views

Abstract - 14

PDF (Russian) - 0

PlumX

Article Metrics

Metrics Loading ...

Dimensions


Copyright (c) 2015 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies