Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Background. In this article the results of own research of the cytokine profile in atopic dermatitis (AD) adults and children depending on age are provided. Materials and methods. 88 patients with AD (54 children aged from 1 year to 16 years old and 24 adults aged from 21 years to 56 years old) were included in the study. Cytokine profile of a number of cytokines: IL-4, IL-5, IL-22, IL-31, IL-33, and transforming growth factor TGFβ1, eotaxin, eotaxin2 was examined. Results. Significant differences in IL-22, CC chemokines (eotaxin and eotaxin-2) and TGFβ levels depending on the age and severity of atopic dermatitis were found.

Full Text

Restricted Access

About the authors

E E Varlamov

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia

O G Elisyutina

Institute of Immunology Moscow, Russia

T V Vinogradova

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia

E S Fedenko

Institute of Immunology Moscow, Russia

A N Pampura

Allergology and clinical immunology department of the Research Clinical Institute of Pediatrics named after academician Y.E. Veltishev Moscow, Russia


  1. Williams H., Flohr C. How epidemiology has challenged 3 prevailing concepts about atopic dermatitis. J. Allergy Clin. Immunol. 2006, v. 118, p. 209-213.
  2. Ozkaya E. Adult-onset atopic dermatitis. J. Am. Acad. Dermatol. 2005, v. 52, p. 579-582.
  3. Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., ГЭОТАР-Медиа. 2009, 654 c.
  4. Bieber T. Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy. 2012, v. 67, p. 1475-1482.
  5. Bieber T. Mechanisms of disease Atopic Dermatitis. N. Engl. J. Med. 2008, v. 358, р. 1483-1494.
  6. Novak N., Valenta R., Bohle B. et al. Fcepsilon RI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J. Allergy Clin. Immunol. 2004, v. 113, p. 949-957.
  7. Damps-Konstanska I., Gruchata-Niedoszytko M., Wilkowska A. et al. Serum eosinophil cationic protein in patient withperennial rhinitis and atopic dermatitis, allergic to house dust mites. Pol. Merkur. Lekarski. 2005, v. 19, p. 765-768.
  8. Pucci N., Novembre E., Cammarata M. et al. Scoring atopic dermatitis in infants and young children: distinctive features of SCORAD index. Allergy. 2005, v. 60, p. 113-116.
  9. Commins S., Borish L., Steinke J. Immunologic messenger molecules: Cytokines, interferons, and chemokines. J. Allergy Clin. Immunol. 2010, v. 125, p. 53-72.
  10. Варламов E.E., Виноградова T.B., Чусляева A.A., Пампура A.H. Биомаркеры аллергического воспаления и тяжесть атопического дерматита у детей. Рос. Аллергол. Журн. 2012, № 5, с. 31-35.
  11. Eichenfield L.F., Tom W.L., Chamlin S.L. et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J. Am. Acad. Dermatol. 2014, v. 70, p. 338-351.
  12. Souwer Y., Szegedi K., Kapsenberg M. et al. IL-17 and IL-22 in atopic allergic disease. Current Opinion in Immunology. 2010, v. 22, p. 821-826.
  13. Wolk K., Kunz S., Witte E. et al. IL-22 increases the innate immunity of tissues. Immunity. 2004, v. 21, p. 241-254.
  14. Souwer Y., Szegedi K., Kapsenberg M.L., de Joing E.C. IL-17 and IL-22 in atopic allergic deseases. Curr. Opin. Immunol. 2010, v. 22, p. 821-826.
  15. Чусляева А.А. Клинико-патогенетичексое значение цитокинов и медиаторов аллергического воспаления у детей с атопическим дерматитом. Автореферат диссертации канд. мед. наук. М., 2013, 24 с.
  16. Tomomitsu M.M., Sugaya M., Fujita H. et al. Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. J. Invest. Dermatol. 2010, v. 130, p. 2304-2311.
  17. Li A.G., Wang D., Feng X.H., Wang X.J. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO. J. 2004, v. 23, p. 1770-1781.
  18. Owczarec W., Palpinska M., Targowski T. et al. Analysis of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. Cytocine. 2010, v. 50, p. 181-185.
  19. Kiehl P., Falkenberg K., Vogelbruch M., Kapp A. Tissue eosinophilia in acute and chronic dermatitis: a morphometric approach using quantitative image analysis of immunostaining. Br. J. Dermatol. 2001, v. 145, p. 720-729.
  20. Sugaya M. Cutaneous lymphoma and chemokin. Nihon Rinsho Meneki Gakkai Kaishi. 2011, v. 34, p. 91-98.
  21. Antoniu S.A., Pitrakinra A. A dual IL-4/IL-13 antagonist for the potential treatment of asthma and eczema. Curr. Opin. Investig. Drugs. 2010, v. 11, p. 1286-1294.
  22. Kasperkiewicz M., Schmidt E., Frambach Y et al. Improvement of treatment-refractory atopic dermatitis by immunoadsorbtion: a pilot study. J. Allergy Clin. Immunol. 2011, v. 127, p. 267-270.

Copyright © Pharmarus Print Media, 2016

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies