THE STUDY OF BALANCE OF Th1/Th2 IMMUNE RESPONSE DURING VIRUS-INDUCED ASTHMA EXACERBATION



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Abstract

Bronchial asthma (BA) is the most common chronic disease of the airways affecting up to 18% of population in different regions of the world. Respiratory viruses such as rhinoviruses and respiratory syncytial virus (RSV) are the main causes of BA exacerbations. Current data demonstrate the major role of Th1- and Th2-response and corresponding cytokines in the development of infectious and allergic inflammation of the airways. At the same time, there are no data available concerning changes in Th1/Th2-balance during virus-induced asthma exacerbations. In the current study, we evaluated Th1/Th2-balance using developed mouse model of RSV-induced BA exacerbation. In was demonstrated, that RSV infection does not increase Th2-immune response but enhances Th1-response that shifts Th1/Th2-balance towards Th1.

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About the authors

A R Gaisina

Email: ar.gaysina@nrcii.ru
Institute of Immunology Moscow, Russia

I P Shilovskiy

Institute of Immunology Moscow, Russia

A A Nikonova

Institute of Immunology Mechnikov Research Institute for Vaccines and Sera Moscow, Russia

M S Sundukova

Institute of Immunology Moscow, Russia

M A Zaretskaia

Institute of Immunology Moscow, Russia

V V Smirnov

Institute of Immunology First Moscow state medical university named after I.M. Sechenov Moscow, Russia

O Y Kamishnikov

Institute of Immunology Moscow, Russia

A S Ivanova

Institute of Immunology Moscow, Russia

M R Khaitov

Institute of Immunology Moscow, Russia

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