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CHARACTERISTICS OF SENSITIZATION IN CHILDREN WITH SEVERE ATOPIC DERMATITIS FOR THE FIRST FOUR YEARS OF LIFE
- Authors: Kamaltynova EM1, Afanasyeva MC1, Fedorova OS1, Belonogova EG1
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Affiliations:
- Federal state budgetary educational institution of higher professional education «Siberian state medical University» Ministry of healthcare of the Russian Federation
- Issue: Vol 14, No 4-5 (2017)
- Pages: 61-65
- Section: Articles
- Submitted: 10.03.2020
- Published: 15.12.2017
- URL: https://rusalljournal.ru/raj/article/view/296
- DOI: https://doi.org/10.36691/RJA296
- ID: 296
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Abstract
Background. To reveal the regularities of sensitization formation in children with atopic dermatitis (AD) in first four years of life. Methods. Continuous crosssectional study of 69 children with an established diagnosis of AD from age 0 to 4 years was conducted. Severity was assessed according to the SCORAD scale. Clinical examination included: general and biochemical blood tests, determination of total IgE and allergenspecific IgE (IgEs) in serum against the most common epidermal and food allergens with ImmunoCAP, Phadia IDM (Sweden) technology. Results. Diagnostically significant levels of IgEs to these allergens had 68,11% of patients. Sensitization to cow’s milk was estimated in 38,98% (n=23), to chicken egg and its components in 67,92% (n=36), to chicken protein in 67,44% (n=29), to yolk in 54,28% (n=19), to cat epithelium in 47,5% (n=19) of children. Conclusion. Sensitization to food allergens marks the early development of sensitization to exogenous allergens, predominantly to the cat epithelium. Sensitization to house dust mites develops less frequently, but can also occur in children under one year of age. Sensitization to cat epithelium can accompany food sensitization as well as to be an independent cause of AD.
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About the authors
E M Kamaltynova
Federal state budgetary educational institution of higher professional education «Siberian state medical University» Ministry of healthcare of the Russian Federation
Email: eleant21@yandex.ru
2, Moscow Highway, Tomsk, 634050, Russia
M C Afanasyeva
Federal state budgetary educational institution of higher professional education «Siberian state medical University» Ministry of healthcare of the Russian Federation2, Moscow Highway, Tomsk, 634050, Russia
O S Fedorova
Federal state budgetary educational institution of higher professional education «Siberian state medical University» Ministry of healthcare of the Russian Federation2, Moscow Highway, Tomsk, 634050, Russia
E G Belonogova
Federal state budgetary educational institution of higher professional education «Siberian state medical University» Ministry of healthcare of the Russian Federation2, Moscow Highway, Tomsk, 634050, Russia
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