Bronchial asthma in combination with chronic rhinosinusitis with nasal polyps: epidemiology, prevalence and peculiarities of their relationship



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Abstract

Asthma in most cases is under control due to the success of modern pharmacotherapy. At the same time questions concerning the treatment of asthma and comorbidities like chronic rhinosinusitis with nasal polyps (CRSwNP) remain unresolved. Among the causes of СRSwNP formation a microbial aggression or an inadequate immune response (allergy) to various types of antigens (allergens) are considered. Congenital, individual characteristics and abnormalities of the corresponding anatomical structures are also cited as factors contributing to the development of CRSwNP. A functional integrated immunity system - the lymphoid tissue associated with the mucous membranes (MALT), infectious and allergic inflammation in the upper respiratory tract can significantly affect the lower respiratory tract and vice versa. Inflammation is the cornerstone of CRSwNP pathogenesis, that’s why understanding of inflammatory response will reveal the mechanisms of asthma severity in combination with CRSwNP.

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About the authors

M E Dyneva

NRC Institute of Immunology FMBA of Russia

Email: amanturliva.miramgul@mail.ru

O M Kurbacheva

NRC Institute of Immunology FMBA of Russia

E L Savlevich

Central State Medical Academy of Department for Presidential Affairs of the Russian Federation

References

  1. Курбачёва ОМ, Павлова КС. Возможно ли улучшение контроля бронхиальной астмы без увеличения доз глюкокортикостероидов? Практическая пульмонология. 2017;2:14-21 [Kurbacheva OM, Pavlova KS. Vozmozhno li uluchshenie kontrolja bronhial’noj astmy bez uvelichenija doz gljukokortikosteroidov? Prakticheskaja pul’monologija. 2017;2:14-21 (In Russ.)].
  2. Курбачёва ОМ, Павлова КС. Аллерген-специфическая иммунотерапия: современные возможности. Астма и аллергия. 2015;3:16-20 [Kurbacheva OM, Pavlova KS. Allergen-specificheskaja immunoterapija: sovremennye vozmozhnosti. Astma i allergija. 2015;3:16-20 (In Russ.)].
  3. Boulet LP, Boulay ME. Asthma-related comorbidities. Expert Rev Respir Med. 2011;(5):377-393. doi: 10.1586/ers.11.34.
  4. Курбачева ОМ, Швец СМ. Бронхиальная астма: как правильно начать лечение больного? Астма и аллергия. 2015;2:12-17 [Kurbacheva OM, Shvec SM. Bronhial’naja astma: kak pravil’no nachat’ lechenie bol’nogo? Astma i allergija. 2015;2:12-17 (In Russ.)].
  5. Курбачёва ОМ, Павлова КС. Фенотипы и эндотипы бронхиальной астмы: от патогенеза и клинической картины к выбору терапии. Российский Аллергологический Журнал. 2003; 1: 15-24 [Kurbacheva OM, Pavlova KS. Fenotipy i endotipy bronkhial’noi astmy: ot patogeneza i klinicheskoi kartiny k vyboru terapii. Rossiiskii Allergologicheskii Zhurnal. 2003;1:15-24 (In Russ.)].
  6. Humbert M, Holgate S, Boulet LP, Bousquet J. Asthma control or severity: that is the question. Allergy. 2007;(62):95-101. doi: 10.1111/j.1398-9995.2006.01308.x.
  7. Eric DB, Homer AB, Bousquet J, Busse WB, Clark T, Romain AP et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. Am J Respir Crit Care Med. 2004;(170):836-844. DOI: 10.1164/ rccm.200401-033oc.
  8. Чичкова НВ. Бронхиальная астма и заболевания полости носа и околоносовых пазух: единство патологических процессов в дыхательной системе. Русский медицинский журнал. 2015;18:1132-1136 [Chichkova NV. Bronhial’naja astma i zabolevanija polosti nosa i okolonosovyh pazuh: edin stvo patologicheskih processov v dyhatel’noj sisteme. Russkij medicinskij zhurnal. 2015;18:1132-1136 (In Russ.)].
  9. Soler ZM, Mace JC, Litvack JR, Smith TL. Chronic rhinosinusitis, race, and ethnicity. Am J Rhinol Allergy. 2012;(26):110-116, 2012. doi: 10.2500/ajra.2012.26.3741.
  10. Hamilos DL. Chronic rhinosinusitis: Epidemiology and medical management. J Allergy Clin Immunol. 2011;(128):693-707. doi: 10.1016/j.jaci.2011.08.004.
  11. Khalmuratova R, Park JW, Shin HW. Immune Cell Responses and Mucosal Barrier Disruptions in Chronic Rhinosinusitis. Immune Netw. 2017;(17):60. doi: 10.4110/in.2017.17.1.60.
  12. Вознесенский НА, Княжеская НП. Полипозный риносинусит и бронхиальная астма : взгляд пульмонолога. Практическая пульмонология. 2015;1:19-22 [Voznesenskij NA, Knjazheskaja NP. Polipoznyj rinosinusit i bronhial’naja astma : vzgljad pul’monologa. Prakticheskaja pul’monologija. 2015;1:19-22 (In Russ.)].
  13. Rowe-Jones JM. The link between the nose and lung, perennial rhinitis and asthma - is it the same disease? Allergy. 1997;(52):20-28. doi: 10.1111/j.1398-9995.1997.tb04818.x.
  14. Togias A. Rhinitis and asthma: Evidence for respiratory system integration. J Allergy Clin Immunol. 2003;(111):1171-1183. doi: 10.1067/mai.2003.1592.
  15. Чичкова Н. Бронхиальная астма и полипозный риносинусит : особенности клинического течения и тактика ведения больных. Астма и аллергия. 2015;1:19-22 [Chichkova N. Bronhial’naja astma i polipoznyj rinosinusit : osobennosti klinicheskogo techenija i taktika vedenija bol’nyh. Astma i allergija. 2015;1:19-22 (In Russ.)].
  16. Kowalski ML, Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Bochenek G et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy Eur J Allergy Clin Immunol. 2013;(68):1219-1232. doi: 10.1111/all.12260.
  17. Whitney WS, Anju TP, Lydia S, Norton JE, Kern RC, David BC et al. A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men. Immunity, Inflamm. Dis. 2015;(3):14-22. doi: 10.1002/iid3.46.
  18. Gelardi M, Iannuzzi L, Tafuri S, Passalacqua G, Quaranta N. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history. Acta Otorhinolaryngol. Ital. 2014;(34):36-41. doi: 10.1002/alr.21193.
  19. Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T et al. Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe. Allergy Eur J Allergy Clin Immunol. 2012;(67): 91-98. doi: 10.1111/j.1398-9995.2011.02709.x.
  20. Settipane GA, Chafee FH. Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol. 1977;(59):17-21. doi: 10.1016/0091-6749(77)90171-3.
  21. Larsen K. The clinical relationship of nasal polyps to asthma. Allergy and Asthma Proceedings. 1996;(17):243-249. doi: 10.2500/108854196778662255.
  22. Alobid I, Cardelus S, Benitez P, Guilemany JM, Ferrer JR, Cesar P et al. Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis. Rhinology. 2011;(49):519-524.
  23. Dixon AE, Kaminsky DA, Holbrook JT, Wise RA, Shade DM, Irvin CG. Allergic rhinitis and sinusitis in asthma differential: Effects on symptoms and pulmonary function. Chest. 2006;(130):429-435. doi: 10.1378/chest.130.2.429.
  24. Chakapan P, Sagar K, Citardi MJ, Samer F, Paul P, Amber L. Prevalence of Confirmed Asthma Varies in Chronic Rhinosinusitis Subtypes. Int Forum Allergy Rhinol. 2016;(6):373-377. doi: 10.1002/alr.21674.
  25. Johansson L, Akerlund A, Holmberg K, Melen I, Bende M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol. 2003;(112):625-629. doi: 10.1177/000348940311200709.
  26. Bruce KT, Rakesh Kc, Pollak J, Kato A, Conley DB, Peters AT, Grammer LC et al. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2013;(131):1350-1360. doi: 10.1016/j.jaci.2013.02.002.
  27. Bachert C, Claeys S, Tomassen P, Zele TV, Zhang N. Rhinosinusitis and asthma: A link for asthma severity. Curr Allergy Asthma Rep. 2010;(10)194-201. doi: 10.1007/s11882-010-0096-0.
  28. Bachert С, Zhang N. Chronic rhinosinusitis and asthma: Novel understanding of the role of IgE ‘above atopy. J Intern Med. 2012;(272):133-143. doi: 10.1111/j.1365-2796.2012.02559.x.
  29. Min YG, Jung HW, Kim HS, SK P, Ky Y Prevalence and risk factors of chronic sinusitis in Korea: results of a nationwide survey. Eur. Arch. oto-rhino-laryngology Off. J. Eur. Fed. OtoRhino-Laryngological Soc. Affil. with Ger. Soc. Oto-Rhino-Laryngology - Head Neck Surg. 1996;(253):435-439. doi: 10.1007/bf00168498.
  30. Hedman J, Kaprio J, Poussa T. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol. 1999;(28):717-722. doi: 10.1093/ije/28.4.717
  31. Larsen K, Tos M. Clinical course of patients with primary nasal polyps. Acta Oto-Laryngologica. 1994;(114):556-559. doi: 10.3109/00016489409126104.
  32. Moloney JR. Nasal polyps, nasal polypectomy, asthma, and aspirin sensitivity. Their association in 445 cases of nasal polyps. J Laryngol Otol. 1997;(91):837-846. DOI: 10.1017/ s0022215100084450.
  33. Drake LAB, Lowe D, Swanston A, Grace A. Clinical profile and recurrence of nasal polyps. J Laryngol Otol. 1984;(98):783-793. doi: 10.1017/s0022215100147462.
  34. Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps. Rhinology. 2012;(20):1-136.
  35. Szczeklik A, Nizankowska E, Duplaga M. Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J Off J Eur Soc Clin Respir Physiol. 2000;(16):432-436.
  36. Бондарева ГП. Астматическая триада. Клинико-иммунологическая характеристика. Пути формирования. Терапевтические подходы. Дисс. докт. мед. наук. 270 [Bondareva GP. Astmaticheskaja triada. Kliniko-immunologicheskaja harakteristika. Puti formirovanija. Terapevticheskie podhody. Diss. dokt. med. nauk. 270 (In Russ.)].
  37. Braunstahl GJ, Kleinjan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med. 2000;(161):2051-2057. DOI: 10.1164/ ajrccm.161.6.9906121.
  38. Bachert С, Zhang N, Holtappels G, Lobel LD, Cauwenberge P, Liu S, Lin P et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol. 2010;(126):962-968. doi: 10.1016/j.jaci.2010.07.007.
  39. Ponikau J, David AS, Kephart GM, Kern E, Gaffey TA, Tarara J et al. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: Is the histopathology similar to asthma? J Allergy Clin Immunol. 2003;(112):877-882. doi: 10.1016/j.jaci.2003.08.009.
  40. Курбачёва ОМ, Амантурлиева МЕ. Роль барьерной функции слизистых оболочек при аллергических заболеваниях и при сублингвальной аллерген-специфической иммунотерапии. Бюллетень сибирской медицины. 2017;(16):32-46 [Kurbacheva OM, Amanturlieva ME. Rol’ bar’ernoj funkcii slizistyh obolochek pri allergicheskih zabolevanijah i pri sublingval’noj allergen-specificheskoj immunoterapii. Bjulleten’ sibirskoj mediciny. 2017;(16):32-46 (In Russ.)]. doi: 10.20538/1682-0363-2017-2-32-46.
  41. Гущин ИС. Трансэпителиальный запуск аллергического ответа. Российский аллергологический журнал. 2016;(3):3-10 [Gushhin IS. Transjepitelial’nyj zapusk allergicheskogo otveta. Rossijskij allergologicheskij zhurnal. 2016;(3):3-10 (In Russ.)].
  42. Рязанцев СВ, Хмельницкая НМ, Тырнова Е.В. Роль слизистой оболочки в защите ЛОР-органов от потенциально патогенных для организма антигенных факторов. Вестник оториноларингологии. 2000;3:60-64 [Rjazancev SV, Hmel’nickaja NM, Tyrnova E.V. Rol’ slizistoj obolochki v zashhite LOR-organov ot potencial’no patogennyh dlja organizma antigennyh faktorovju festnik otorinolaringologii. 2000;3:60-64 (In Russ.)].
  43. Zhang N, Crombruggen KV, Gevaert E, Bachert C. Barrier function of the nasal mucosa in health and type-2 biased airway diseases. Allergy Eur J Allergy Clin Immunol. 2016;(71):295-307. doi: 10.1111/all.12809.
  44. Sethi S, Murphy TF. Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease. New England Journal of Medicine. 2008;(359):2355-2365. DOI: 10.1056/ nejmra0800353.
  45. Федосенко CT, Огородова ЛМ, Карнаушкина МА, Куликов ЕС, Деев ИА, Кириллова НА. Роль сообщества микроорганизмов в патогенезе хронической обструктивной болезни легких. Бюллетень сибирской медицины. 2014;1:153-160 [Fedosenko SB, Ogorodova LM, Karnaushki-na MA, Kulikov ES, Deev IA, Kirillova NA. Rol’ soobshhestva mikroorganizmov v patogeneze hronicheskoj obstruktivnoj bolezni legkih. Bjulleten’ sibirskoj mediciny. 2014;1:153-160 (In Russ.)].
  46. Хаитов РМ. Физиология иммунной системы. 2005;428 [Haitov RM. Fiziologija immunnoj sistemy. 2005;428 (In Russ.)].
  47. Brandtzaeg P, Jahnsen FL, Farstad IN. Immunobiology and immunopathology of the upper airway mucosa. Folia Otorhinolaryng Pathol Respir. 1998;(4):74-83.
  48. Brandtzaeg P. Immunocompetent cells of the upper airway: functions in normal and diseased mucosa. Eur Arch Otorhinolaryng. 1995;(252):8-21. doi: 10.1007/bf02484429.
  49. Brandtzaeg P. Two types of IgA immunocytes in man. Nat New Biol. 1973;(243):142-143. doi: 10.1038/newbio243142a0.
  50. Pipkorn U, Karlsson G, Enerbäck L. The cellular response of the human allergic mucosa to allergen exposure. J Allergy Clin Immunol. 1988;(82):172-178. doi: 10.1016/0091-6749(88)90143-1.
  51. Безрукова ЕБ, Молотилов БА. Динамика клинической картины и показателей локального иммунитета при проведении аллерген-специфической иммунотерапии при сочетанных формах сенсибилизации у больных поллинозом. Российский Аллергологический Журнал. 2010;(3):14-18 [Bezrukova EB, Molotilov BA. Dinamika klinicheskoj kartiny i pokazatelej lokal’nogo immuniteta pri provedenii allergen-specificheskoj immunoterapii pri sochetannyh formah sensibilizacii u bol’nyh pollinozom. Rossijskij Allergologicheskij Zhurnal. 2010;(3):14-18 (In Russ.)].
  52. Кирдеева АИ, Косяков СЯ. Особенности эндотипирования и фенотипирования хронического риносинусита. Российская ринология. 2017;(25):58-63 [Kirdeeva AI, Kosjakov SJa. Osobennosti jendotipirovanija i fenotipirovanija hronicheskogo rinosinusita. Rossijskaja rinologija. 2017;(25):58-63 (In Russ.)].
  53. Jenny MM, Trifari S, Crellin NK, Peters CP, Drunen CM, Piet B et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011;(12):1055-1062. DOI: doi.org/10.1038/ni.2104.
  54. Shaw JL, Fakhri S, Citardi MJ, Porter PC, Corry DB et al. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2013;(188):432-439. DOI: 10.1164/ rccm.201212-2227oc.
  55. Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 2008;(223):20-38. doi: 10.1111/j.1600-065x.2008.00624.x.
  56. Halim TY, Krauß RH, Sun AC, Takei F. Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation. Immunity. 2012;(36):451-463. doi: 10.1016/j.immuni.2011.12.020.
  57. Reh DD, Wang Y, Ramanathan M, Lane AP. Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J Rhinol. 2010;(24):105-109. doi: 10.2500/ajra.2010.24.3446.
  58. Lee TJ, Fu CH, Wang CH, Huang CC, Huang C, Chang PH et al. Impact of chronic rhinosinusitis on severe asthma patients. PLoS One. 2017;(12):e017104. doi: 10.1371/journal. pone.0171047.
  59. Hayes SM, Howlin R, Johnston DA, Webb JS, Clarke SC, Stoodleyet P et al. Intracellular residency of Staphylococcus aureus within mast cells in nasal polyps: A novel observation. J Allergy Clin. Immunol. 2015;(135):1648-1651e5. DOI: 10.1016/j. jaci.2014.12.1929.
  60. Zele TV, Claeys S, Gevaert P, Maele GV, Holtappels G, Cauwenberge PV et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy. 2006;(61): 1280-1289. doi: 10.1111/j.1398-9995.2006.01225.x.
  61. Lan F, Zhang N, Zhang J, Krysko O, Zhang Q, Xian J et al. Forkhead box protein 3 in human nasal polyp regulatory T-cells is regulated by the protein suppressor of cytokine signaling 3. J Allergy Clin Immunol. 2013;(132):1314-1321.e3. doi: 10.1016/j.jaci.2013.06.010.
  62. Whitney WS, Lee RJ, Schleimer RP, Cohen NA. Chronic Rhinosinusitis Pathogenesis HHS Public Access. J Allergy Clin Immunol. 2015;(136):1442-1453. DOI: 10.1016/j. jaci.2015.10.009.
  63. Huls KE, Norton JE, Suh L, Zhong Q, Mahdavinia M, Simon P et al. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy Clin Immunol. 2013;(131):1075-1083.e7. doi: 10.1016/j.jaci.2013.01.043.
  64. Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R et al. Evidence of a role for B-cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2008;(121):1385-1392. DOI: 10.1016/j. jaci.2008.03.002.
  65. Zele TV, Gevaert P, Holtappels G, Cauwenberge P, Bachert C. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy. 2007;(37):1840-1847. doi: 10.1111/j.1365-2222.2007.02838.x.
  66. Watelet JB, Zele TV, Gjomarkaj M, Canonica GW, Dahlen SE, Fokkens W et al. Tissue remodelling in upper airways: Where is the link with lower airway remodelling? Allergy. 2006;(61):1249-1258. doi: 10.1111/j.1398-9995.2006.01226.x.
  67. Undem BJ, McAlexander M, Hunter DD. Neurobiology of the upper and lower airways. Allergy. 1999;(54):81-93. doi: 10.1111/j.1398-9995.1999.tb04409.x.
  68. Bilodeau L, Boulay ME, Prince P, Boisvert P, Boulet LP. Comparative clinical and airway inflammatory features of asthmatics with or without polyps. Rhinology. 2010;(48):420-425.
  69. Awad OG, Lee JH, Fasano MB, Graham SM. Sinonasal outcomes after endoscopic sinus surgery in asthmatic patients with nasal polyps: a difference between aspirin-tolerant and aspirin-induced asthma? Laryngoscope. 2008;(118):1282-1286. doi: 10.1097/mlg.0b013e318170af1e.
  70. Фисенко ВП, Чичкова НВ. Лейкотриены: участие в патогенезе аллергического ринита, бронхиальной астмы и возможности фармакологического воздействия. Врач. 2007;(10):14-19.
  71. Kowalski ML, Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Bochenek G et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2013;(68):1219-1232. doi: 10.1111/all.12260.
  72. Yacoub MR, Trimarchi M, Cremona G, Farra SD, Ramirez GA, Canti V et al. Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps? Clin Mol Allergy. 2015;(13):1-6. DOI: 10.1186/ s12948-015-0026-8.

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