Moisturizers for the treatment and prophylaxis of atopic dermatitis exacerbations

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Abstract

Atopic dermatitis is a global problem with increasing prevalence. Genetic predisposition to allergies, epidermal barrier dysfunction, and T2 immune response underlie atopic dermatitis. Xerosis, itchy skin, and exacerbation are the main atopic dermatitis symptoms, leading to increased permeability of allergens and microbes through the damaged epidermis and to the development of sensitization. The main purpose of atopic dermatitis therapy is to achieve long-term remission and improve quality of life. Topical treatment includes glucocorticosteroids, topical calcineurin inhibitors, and emollients to reduce inflammation, xerosis, and infection prevention. Daily use of effective emollients as basic skin care can improve epidermal barrier function, provide skin hydration, and reduce the need for topical glucocorticosteroids.

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About the authors

Daria D. Chernushevich

National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia

Email: chernushevitchdasha@yandex.ru
ORCID iD: 0000-0003-0006-2773
SPIN-code: 2497-5608
Russian Federation, Moscow

Olga V. Shtyrbul

National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ovs-495@yandex.ru
ORCID iD: 0000-0001-8254-9715
SPIN-code: 4146-1788

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Elena I. Grebenchenko

National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ghellena@mail.ru
ORCID iD: 0000-0002-0756-5464
SPIN-code: 6726-3997

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Elena S. Fedenko

National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia

Author for correspondence.
Email: efedks@gmail.com
ORCID iD: 0000-0003-3358-5087
SPIN-code: 5012-7242

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

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