Molecular allergology place in allergen-specific immunotherapy
- Authors: Timoshenko D.O.1, Pavlova K.S.1, Kurbacheva O.M.1,2, Ilina N.I.1,2,3
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Affiliations:
- National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 19, No 3 (2022)
- Pages: 336-345
- Section: Reviews
- URL: https://rusalljournal.ru/raj/article/view/1572
- DOI: https://doi.org/10.36691/RJA1572
- ID: 1572
Cite item
Abstract
Laboratory methods of allergy diagnosis are an essential tool in the allergist’s daily practice. Molecular allergodiagnostics is an advanced examination method that detects individual allergocomponent sensitization. The risk prediction of severe allergic reactions is the main area of its application, as well as the creation of personalized dietary recommendations for patients with food allergies. Clinical and anamnesis data are fundamental, supplemented by the results of traditional methods of allergy examination (skin prick tests or the specific immunoglobulin E level to whole allergens), in determining the appointment of allergen immunotherapy indications. The widespread use of such resource-intensive examination as molecular allergodiagnostics for all patients is unjustified before prescribing allergen immunotherapy. Additionally, decisions on the allergen immunotherapy continue or the termination cannot be made based on the change data in the level of clinically relevant specific IgE. Concurrently, its use as a third-line diagnostic method can help in solving difficult clinical tasks related to the identification of a causally significant allergen in patients with respiratory allergy symptoms during the seasons of the simultaneous dusting of several plants, as well as differentiate the true from the cross-sensitization in polysensitized patients. The use of molecular allergodiagnostics will be mandatory in prescribing recombinant therapeutic allergens, due to the need for a personalized choice of the drug.
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About the authors
Daria O. Timoshenko
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: d.o.timoshenko@gmail.com
ORCID iD: 0000-0002-7585-1390
SPIN-code: 2714-0906
MD
Russian Federation, MoscowKsenia S. Pavlova
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ksenimedical@gmail.com
ORCID iD: 0000-0002-4164-4094
SPIN-code: 7593-0838
Scopus Author ID: 7004658159
ResearcherId: P-9255-2017
MD, Cand. Sci. (Med.)
Russian Federation, MoscowOksana M. Kurbacheva
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: kurbacheva@gmail.com
ORCID iD: 0000-0003-3250-0694
SPIN-code: 5698-6436
MD, Dr. Sci. (Med.), Professor
Russian Federation, Moscow; MoscowNatalia I. Ilina
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; The Russian National Research Medical University named after N.I. Pirogov
Email: instimmun@yandex.ru
ORCID iD: 0000-0002-3556-969X
SPIN-code: 6715-5650
MD, Dr. Sci. (Med.), Professor
Russian Federation, Moscow; Moscow; MoscowReferences
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